Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SVIL (supervillin)

Identity

Other alias-
HGNC (Hugo) SVIL
LocusID (NCBI) 6840
Atlas_Id 53334
Location 10p11.23  [Link to chromosome band 10p11]
Location_base_pair Starts at 29457348 and ends at 29634972 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CERS6 (2q24.3) / SVIL (10p11.23)DHX29 (5q11.2) / SVIL (10p11.23)PRKDC (8q11.21) / SVIL (10p11.23)
SVIL (10p11.23) / MNAT1 (14q23.1)SVIL (10p11.23) / PEAK1 (15q24.3)SVIL (10p11.23) / SVIL (10p11.23)
ZNF106 (15q15.1) / SVIL (10p11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SVIL   11480
Cards
Entrez_Gene (NCBI)SVIL  6840  supervillin
Aliases
GeneCards (Weizmann)SVIL
Ensembl hg19 (Hinxton)ENSG00000197321 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197321 [Gene_View]  ENSG00000197321 [Sequence]  chr10:29457348-29634972 [Contig_View]  SVIL [Vega]
ICGC DataPortalENSG00000197321
TCGA cBioPortalSVIL
AceView (NCBI)SVIL
Genatlas (Paris)SVIL
WikiGenes6840
SOURCE (Princeton)SVIL
Genetics Home Reference (NIH)SVIL
Genomic and cartography
GoldenPath hg38 (UCSC)SVIL  -     chr10:29457348-29634972 -  10p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SVIL  -     10p11.23   [Description]    (hg19-Feb_2009)
EnsemblSVIL - 10p11.23 [CytoView hg19]  SVIL - 10p11.23 [CytoView hg38]
Mapping of homologs : NCBISVIL [Mapview hg19]  SVIL [Mapview hg38]
OMIM604126   
Gene and transcription
Genbank (Entrez)AF051850 AF051851 AF109135 AI028650 AK001792
RefSeq transcript (Entrez)NM_001323599 NM_001323600 NM_003174 NM_021738
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SVIL
Cluster EST : UnigeneHs.684405 [ NCBI ]
CGAP (NCI)Hs.684405
Alternative Splicing GalleryENSG00000197321
Gene ExpressionSVIL [ NCBI-GEO ]   SVIL [ EBI - ARRAY_EXPRESS ]   SVIL [ SEEK ]   SVIL [ MEM ]
Gene Expression Viewer (FireBrowse)SVIL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6840
GTEX Portal (Tissue expression)SVIL
Human Protein AtlasENSG00000197321-SVIL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95425   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95425  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95425
Splice isoforms : SwissVarO95425
PhosPhoSitePlusO95425
Domaine pattern : Prosite (Expaxy)HP (PS51089)   
Domains : Interpro (EBI)ADF-H/Gelsolin-like_dom_sf    Gelsolin-like_dom    SV/p205    Villin/Gelsolin    Villin_headpiece    Villin_headpiece_dom_sf   
Domain families : Pfam (Sanger)Gelsolin (PF00626)    VHP (PF02209)   
Domain families : Pfam (NCBI)pfam00626    pfam02209   
Domain families : Smart (EMBL)GEL (SM00262)  VHP (SM00153)  
Conserved Domain (NCBI)SVIL
DMDM Disease mutations6840
Blocks (Seattle)SVIL
PDB (RSDB)2K6M    2K6N   
PDB Europe2K6M    2K6N   
PDB (PDBSum)2K6M    2K6N   
PDB (IMB)2K6M    2K6N   
Structural Biology KnowledgeBase2K6M    2K6N   
SCOP (Structural Classification of Proteins)2K6M    2K6N   
CATH (Classification of proteins structures)2K6M    2K6N   
SuperfamilyO95425
Human Protein Atlas [tissue]ENSG00000197321-SVIL [tissue]
Peptide AtlasO95425
HPRD04992
IPIIPI00412650   IPI00018370   IPI01013044   IPI01012531   IPI01013450   
Protein Interaction databases
DIP (DOE-UCLA)O95425
IntAct (EBI)O95425
FunCoupENSG00000197321
BioGRIDSVIL
STRING (EMBL)SVIL
ZODIACSVIL
Ontologies - Pathways
QuickGOO95425
Ontology : AmiGOpodosome  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  focal adhesion  cytoskeleton organization  skeletal muscle tissue development  actin cytoskeleton  actin cytoskeleton  midbody  cleavage furrow  positive regulation of cytokinesis  microtubule minus-end  costamere  actin filament binding  invadopodium  
Ontology : EGO-EBIpodosome  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  focal adhesion  cytoskeleton organization  skeletal muscle tissue development  actin cytoskeleton  actin cytoskeleton  midbody  cleavage furrow  positive regulation of cytokinesis  microtubule minus-end  costamere  actin filament binding  invadopodium  
NDEx NetworkSVIL
Atlas of Cancer Signalling NetworkSVIL
Wikipedia pathwaysSVIL
Orthology - Evolution
OrthoDB6840
GeneTree (enSembl)ENSG00000197321
Phylogenetic Trees/Animal Genes : TreeFamSVIL
HOGENOMO95425
Homologs : HomoloGeneSVIL
Homology/Alignments : Family Browser (UCSC)SVIL
Gene fusions - Rearrangements
Fusion : QuiverSVIL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSVIL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SVIL
dbVarSVIL
ClinVarSVIL
1000_GenomesSVIL 
Exome Variant ServerSVIL
ExAC (Exome Aggregation Consortium)ENSG00000197321
GNOMAD BrowserENSG00000197321
Varsome BrowserSVIL
Genetic variants : HAPMAP6840
Genomic Variants (DGV)SVIL [DGVbeta]
DECIPHERSVIL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSVIL 
Mutations
ICGC Data PortalSVIL 
TCGA Data PortalSVIL 
Broad Tumor PortalSVIL
OASIS PortalSVIL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSVIL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSVIL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SVIL
DgiDB (Drug Gene Interaction Database)SVIL
DoCM (Curated mutations)SVIL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SVIL (select a term)
intoGenSVIL
Cancer3DSVIL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604126   
Orphanet
DisGeNETSVIL
MedgenSVIL
Genetic Testing Registry SVIL
NextProtO95425 [Medical]
TSGene6840
GENETestsSVIL
Target ValidationSVIL
Huge Navigator SVIL [HugePedia]
snp3D : Map Gene to Disease6840
BioCentury BCIQSVIL
ClinGenSVIL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6840
Chemical/Pharm GKB GenePA36265
Clinical trialSVIL
Miscellaneous
canSAR (ICR)SVIL (select the gene name)
DataMed IndexSVIL
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSVIL
EVEXSVIL
GoPubMedSVIL
iHOPSVIL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:41:05 CET 2019
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