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SVIL (supervillin)

Identity

Alias (NCBI)MFM10
HGNC (Hugo) SVIL
HGNC Alias namearchvillin
LocusID (NCBI) 6840
Atlas_Id 53334
Location 10p11.23  [Link to chromosome band 10p11]
Location_base_pair Starts at 29457338 and ends at 29634971 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CERS6 (2q24.3) / SVIL (10p11.23)DHX29 (5q11.2) / SVIL (10p11.23)PRKDC (8q11.21) / SVIL (10p11.23)
SVIL (10p11.23) / MNAT1 (14q23.1)SVIL (10p11.23) / PEAK1 (15q24.3)SVIL (10p11.23) / SVIL (10p11.23)
ZNF106 (15q15.1) / SVIL (10p11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)SVIL   11480
Cards
Entrez_Gene (NCBI)SVIL    supervillin
AliasesMFM10
GeneCards (Weizmann)SVIL
Ensembl hg19 (Hinxton)ENSG00000197321 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197321 [Gene_View]  ENSG00000197321 [Sequence]  chr10:29457338-29634971 [Contig_View]  SVIL [Vega]
ICGC DataPortalENSG00000197321
TCGA cBioPortalSVIL
AceView (NCBI)SVIL
Genatlas (Paris)SVIL
SOURCE (Princeton)SVIL
Genetics Home Reference (NIH)SVIL
Genomic and cartography
GoldenPath hg38 (UCSC)SVIL  -     chr10:29457338-29634971 -  10p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SVIL  -     10p11.23   [Description]    (hg19-Feb_2009)
GoldenPathSVIL - 10p11.23 [CytoView hg19]  SVIL - 10p11.23 [CytoView hg38]
ImmunoBaseENSG00000197321
Genome Data Viewer NCBISVIL [Mapview hg19]  
OMIM604126   619040   
Gene and transcription
Genbank (Entrez)AF051850 AF051851 AF109135 AI028650 AK001792
RefSeq transcript (Entrez)NM_001323599 NM_001323600 NM_003174 NM_021738
Consensus coding sequences : CCDS (NCBI)SVIL
Gene ExpressionSVIL [ NCBI-GEO ]   SVIL [ EBI - ARRAY_EXPRESS ]   SVIL [ SEEK ]   SVIL [ MEM ]
Gene Expression Viewer (FireBrowse)SVIL [ Firebrowse - Broad ]
GenevisibleExpression of SVIL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6840
GTEX Portal (Tissue expression)SVIL
Human Protein AtlasENSG00000197321-SVIL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95425   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95425  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95425
PhosPhoSitePlusO95425
Domaine pattern : Prosite (Expaxy)HP (PS51089)   
Domains : Interpro (EBI)ADF-H/Gelsolin-like_dom_sf    Gelsolin-like_dom    SV/p205    Villin/Gelsolin    Villin_headpiece    Villin_headpiece_dom_sf   
Domain families : Pfam (Sanger)Gelsolin (PF00626)    VHP (PF02209)   
Domain families : Pfam (NCBI)pfam00626    pfam02209   
Domain families : Smart (EMBL)GEL (SM00262)  VHP (SM00153)  
Conserved Domain (NCBI)SVIL
PDB (RSDB)2K6M    2K6N   
PDB Europe2K6M    2K6N   
PDB (PDBSum)2K6M    2K6N   
PDB (IMB)2K6M    2K6N   
Structural Biology KnowledgeBase2K6M    2K6N   
SCOP (Structural Classification of Proteins)2K6M    2K6N   
CATH (Classification of proteins structures)2K6M    2K6N   
SuperfamilyO95425
AlphaFold pdb e-kbO95425   
Human Protein Atlas [tissue]ENSG00000197321-SVIL [tissue]
HPRD04992
Protein Interaction databases
DIP (DOE-UCLA)O95425
IntAct (EBI)O95425
BioGRIDSVIL
STRING (EMBL)SVIL
ZODIACSVIL
Ontologies - Pathways
QuickGOO95425
Ontology : AmiGOpodosome  protein binding  phosphatidylinositol-4,5-bisphosphate binding  nucleus  cytoplasm  cytoplasm  cytosol  plasma membrane  focal adhesion  skeletal muscle tissue development  actin polymerization or depolymerization  actin cytoskeleton  actin cytoskeleton  actin cytoskeleton  midbody  cleavage furrow  positive regulation of cytokinesis  microtubule minus-end  cell projection  costamere  actin filament severing  actin filament binding  actin filament binding  barbed-end actin filament capping  
Ontology : EGO-EBIpodosome  protein binding  phosphatidylinositol-4,5-bisphosphate binding  nucleus  cytoplasm  cytoplasm  cytosol  plasma membrane  focal adhesion  skeletal muscle tissue development  actin polymerization or depolymerization  actin cytoskeleton  actin cytoskeleton  actin cytoskeleton  midbody  cleavage furrow  positive regulation of cytokinesis  microtubule minus-end  cell projection  costamere  actin filament severing  actin filament binding  actin filament binding  barbed-end actin filament capping  
NDEx NetworkSVIL
Atlas of Cancer Signalling NetworkSVIL
Wikipedia pathwaysSVIL
Orthology - Evolution
OrthoDB6840
GeneTree (enSembl)ENSG00000197321
Phylogenetic Trees/Animal Genes : TreeFamSVIL
Homologs : HomoloGeneSVIL
Homology/Alignments : Family Browser (UCSC)SVIL
Gene fusions - Rearrangements
Fusion : QuiverSVIL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSVIL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SVIL
dbVarSVIL
ClinVarSVIL
MonarchSVIL
1000_GenomesSVIL 
Exome Variant ServerSVIL
GNOMAD BrowserENSG00000197321
Varsome BrowserSVIL
ACMGSVIL variants
VarityO95425
Genomic Variants (DGV)SVIL [DGVbeta]
DECIPHERSVIL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSVIL 
Mutations
ICGC Data PortalSVIL 
TCGA Data PortalSVIL 
Broad Tumor PortalSVIL
OASIS PortalSVIL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSVIL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSVIL
Mutations and Diseases : HGMDSVIL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSVIL
DgiDB (Drug Gene Interaction Database)SVIL
DoCM (Curated mutations)SVIL
CIViC (Clinical Interpretations of Variants in Cancer)SVIL
Cancer3DSVIL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604126    619040   
Orphanet
DisGeNETSVIL
MedgenSVIL
Genetic Testing Registry SVIL
NextProtO95425 [Medical]
GENETestsSVIL
Target ValidationSVIL
Huge Navigator SVIL [HugePedia]
ClinGenSVIL
Clinical trials, drugs, therapy
MyCancerGenomeSVIL
Protein Interactions : CTDSVIL
Pharm GKB GenePA36265
PharosO95425
Clinical trialSVIL
Miscellaneous
canSAR (ICR)SVIL
HarmonizomeSVIL
DataMed IndexSVIL
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSVIL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:56 CEST 2021
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