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SWAP70 (switching B cell complex subunit SWAP70)

Identity

Alias_symbol (synonym)KIAA0640
SWAP-70
Other aliasHSPC321
HGNC (Hugo) SWAP70
LocusID (NCBI) 23075
Atlas_Id 55041
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 9664077 and ends at 9752991 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MBP (18q23) / SWAP70 (11p15.4)SWAP70 (11p15.4) / TXLNA (1p35.1)SWAP70 (11p15.4) / WEE1 (11p15.4)
SWAP70 (11p15.4) / ZNF143 (11p15.4)SWAP70 11p15.4 / WEE1 11p15.4SWAP70 11p15.4 / ZNF143 11p15.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(p15;p15) SWAP70/WEE1
t(11;11)(p15;p15) SWAP70/ZNF143

External links

Nomenclature
HGNC (Hugo)SWAP70   17070
Cards
Entrez_Gene (NCBI)SWAP70  23075  switching B cell complex subunit SWAP70
AliasesHSPC321; SWAP-70
GeneCards (Weizmann)SWAP70
Ensembl hg19 (Hinxton)ENSG00000133789 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133789 [Gene_View]  chr11:9664077-9752991 [Contig_View]  SWAP70 [Vega]
ICGC DataPortalENSG00000133789
TCGA cBioPortalSWAP70
AceView (NCBI)SWAP70
Genatlas (Paris)SWAP70
WikiGenes23075
SOURCE (Princeton)SWAP70
Genetics Home Reference (NIH)SWAP70
Genomic and cartography
GoldenPath hg38 (UCSC)SWAP70  -     chr11:9664077-9752991 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SWAP70  -     11p15.4   [Description]    (hg19-Feb_2009)
EnsemblSWAP70 - 11p15.4 [CytoView hg19]  SWAP70 - 11p15.4 [CytoView hg38]
Mapping of homologs : NCBISWAP70 [Mapview hg19]  SWAP70 [Mapview hg38]
OMIM604762   
Gene and transcription
Genbank (Entrez)AB014540 AF134894 AF161439 AF210818 AI693686
RefSeq transcript (Entrez)NM_001297714 NM_015055
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SWAP70
Cluster EST : UnigeneHs.153026 [ NCBI ]
CGAP (NCI)Hs.153026
Alternative Splicing GalleryENSG00000133789
Gene ExpressionSWAP70 [ NCBI-GEO ]   SWAP70 [ EBI - ARRAY_EXPRESS ]   SWAP70 [ SEEK ]   SWAP70 [ MEM ]
Gene Expression Viewer (FireBrowse)SWAP70 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23075
GTEX Portal (Tissue expression)SWAP70
Human Protein AtlasENSG00000133789-SWAP70 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UH65   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UH65  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UH65
Splice isoforms : SwissVarQ9UH65
PhosPhoSitePlusQ9UH65
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_hand_dom    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)PH (PF00169)   
Domain families : Pfam (NCBI)pfam00169   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)SWAP70
DMDM Disease mutations23075
Blocks (Seattle)SWAP70
PDB (SRS)2DN6   
PDB (PDBSum)2DN6   
PDB (IMB)2DN6   
PDB (RSDB)2DN6   
Structural Biology KnowledgeBase2DN6   
SCOP (Structural Classification of Proteins)2DN6   
CATH (Classification of proteins structures)2DN6   
SuperfamilyQ9UH65
Human Protein Atlas [tissue]ENSG00000133789-SWAP70 [tissue]
Peptide AtlasQ9UH65
HPRD10378
IPIIPI00307200   IPI00903155   IPI00984765   IPI00983591   IPI00983734   
Protein Interaction databases
DIP (DOE-UCLA)Q9UH65
IntAct (EBI)Q9UH65
FunCoupENSG00000133789
BioGRIDSWAP70
STRING (EMBL)SWAP70
ZODIACSWAP70
Ontologies - Pathways
QuickGOQ9UH65
Ontology : AmiGODNA binding  calcium ion binding  protein binding  ATP binding  nucleus  cytoplasm  cytoskeleton  plasma membrane  positive regulation of cytosolic calcium ion concentration  lamellipodium  negative regulation of actin filament depolymerization  positive regulation of actin filament bundle assembly  regulation of protein localization  negative regulation of cell-cell adhesion mediated by integrin  isotype switching  cadherin binding  actin filament bundle assembly  positive regulation of mast cell chemotaxis  negative regulation of peptidyl-serine dephosphorylation  
Ontology : EGO-EBIDNA binding  calcium ion binding  protein binding  ATP binding  nucleus  cytoplasm  cytoskeleton  plasma membrane  positive regulation of cytosolic calcium ion concentration  lamellipodium  negative regulation of actin filament depolymerization  positive regulation of actin filament bundle assembly  regulation of protein localization  negative regulation of cell-cell adhesion mediated by integrin  isotype switching  cadherin binding  actin filament bundle assembly  positive regulation of mast cell chemotaxis  negative regulation of peptidyl-serine dephosphorylation  
NDEx NetworkSWAP70
Atlas of Cancer Signalling NetworkSWAP70
Wikipedia pathwaysSWAP70
Orthology - Evolution
OrthoDB23075
GeneTree (enSembl)ENSG00000133789
Phylogenetic Trees/Animal Genes : TreeFamSWAP70
HOVERGENQ9UH65
HOGENOMQ9UH65
Homologs : HomoloGeneSWAP70
Homology/Alignments : Family Browser (UCSC)SWAP70
Gene fusions - Rearrangements
Fusion : MitelmanSWAP70/WEE1 [11p15.4/11p15.4]  
Fusion : MitelmanSWAP70/ZNF143 [11p15.4/11p15.4]  [t(11;11)(p15;p15)]  
Fusion: TCGA_MDACCSWAP70 11p15.4 WEE1 11p15.4 HNSC LUAD
Fusion: TCGA_MDACCSWAP70 11p15.4 ZNF143 11p15.4 LGG LUAD
Fusion PortalSWAP70 11p15.4 WEE1 11p15.4 HNSC LUAD
Fusion PortalSWAP70 11p15.4 ZNF143 11p15.4 LGG LUAD
Fusion : QuiverSWAP70
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSWAP70 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SWAP70
dbVarSWAP70
ClinVarSWAP70
1000_GenomesSWAP70 
Exome Variant ServerSWAP70
ExAC (Exome Aggregation Consortium)ENSG00000133789
GNOMAD BrowserENSG00000133789
Genetic variants : HAPMAP23075
Genomic Variants (DGV)SWAP70 [DGVbeta]
DECIPHERSWAP70 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSWAP70 
Mutations
ICGC Data PortalSWAP70 
TCGA Data PortalSWAP70 
Broad Tumor PortalSWAP70
OASIS PortalSWAP70 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSWAP70  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSWAP70
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SWAP70
DgiDB (Drug Gene Interaction Database)SWAP70
DoCM (Curated mutations)SWAP70 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SWAP70 (select a term)
intoGenSWAP70
Cancer3DSWAP70(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604762   
Orphanet
DisGeNETSWAP70
MedgenSWAP70
Genetic Testing Registry SWAP70
NextProtQ9UH65 [Medical]
TSGene23075
GENETestsSWAP70
Target ValidationSWAP70
Huge Navigator SWAP70 [HugePedia]
snp3D : Map Gene to Disease23075
BioCentury BCIQSWAP70
ClinGenSWAP70
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23075
Chemical/Pharm GKB GenePA165543694
Clinical trialSWAP70
Miscellaneous
canSAR (ICR)SWAP70 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSWAP70
EVEXSWAP70
GoPubMedSWAP70
iHOPSWAP70
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:40:26 CET 2018
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