SYCP1 (synaptonemal complex protein 1)

2007-02-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
CT8,HOM-TES-14,SCP-1,SCP1
FUSION GENES

Other Information

Locus ID:

NCBI: 6847
MIM: 602162
HGNC: 11487
Ensembl: ENSG00000198765

Variants:

dbSNP: 6847
ClinVar: 6847
TCGA: ENSG00000198765
COSMIC: SYCP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198765ENST00000369518Q15431
ENSG00000198765ENST00000369518A0A024R0I2
ENSG00000198765ENST00000369522Q15431
ENSG00000198765ENST00000369522A0A024R0I2
ENSG00000198765ENST00000455987Q5VXJ5
ENSG00000198765ENST00000613524A0A087WZC3
ENSG00000198765ENST00000618516Q15431
ENSG00000198765ENST00000618516A0A024R0I2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
248508462014Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients.17
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
299153892018Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly.11
160301832005Identification of an epitope derived from the cancer testis antigen HOM-TES-14/SCP1 and presented by dendritic cells to circulating CD4+ T cells.4
275486132016Crystal Structure of C-Terminal Coiled-Coil Domain of SYCP1 Reveals Non-Canonical Anti-Parallel Dimeric Structure of Transverse Filament at the Synaptonemal Complex.3
176081502007[Expression of cancer-testis antigen SCP-1 mRNA in human nasopharyngeal carcinoma].1
263232972015X-ray crystallographic studies of the middle part of the human synaptonemal complex protein 1 coiled-coil domain.1

Citation

Dessen P

SYCP1 (synaptonemal complex protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46452/sycp1