SYCP3 (synaptonemal complex protein 3)

2010-05-01  

Identity

HGNC
SYCP3
LOCATION
12q23.2
LOCUSID
50511
ALIAS
COR1,RPRGL4,SCP3,SPGF4

Other Information

Locus ID:

NCBI: 50511
MIM: 604759
HGNC: 18130
Ensembl: ENSG00000139351

Variants:

dbSNP: 50511
ClinVar: 50511
TCGA: ENSG00000139351
COSMIC: SYCP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139351ENST00000266743Q8IZU3
ENSG00000139351ENST00000266743A0A024RBF8
ENSG00000139351ENST00000392924Q8IZU3
ENSG00000139351ENST00000392924A0A024RBF8
ENSG00000139351ENST00000392927Q8IZU3
ENSG00000139351ENST00000392927A0A024RBF8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146431202003Azoospermia in patients heterozygous for a mutation in SYCP3.53
146431202003Azoospermia in patients heterozygous for a mutation in SYCP3.53
249509652014A molecular model for the role of SYCP3 in meiotic chromosome organisation.37
191102132009Mutations of the SYCP3 gene in women with recurrent pregnancy loss.19
191102132009Mutations of the SYCP3 gene in women with recurrent pregnancy loss.19
182565452008Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries.12
203952012010Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity.12
230692552013Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer.12
221164012011Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.11
168245232006Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia.8

Citation

Dessen P

SYCP3 (synaptonemal complex protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51478/sycp3