Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SYMPK (symplekin)

Identity

Alias_symbol (synonym)SYM
SPK
Other alias
HGNC (Hugo) SYMPK
LocusID (NCBI) 8189
Atlas_Id 74406
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 45815442 and ends at 45863290 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FBXO46 (19q13.32) / SYMPK (19q13.32)PLEC (8q24.3) / SYMPK (19q13.32)SYMPK (19q13.32) / ELSPBP1 (19q13.33)
SYMPK (19q13.32) / MAPK6 (15q21.2)SYMPK (19q13.32) / SYMPK (19q13.32)SYMPK (19q13.32) / TOM1L2 (17p11.2)
SYMPK (19q13.32) / ZNF573 (19q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SYMPK   22935
Cards
Entrez_Gene (NCBI)SYMPK  8189  symplekin
AliasesSPK; SYM
GeneCards (Weizmann)SYMPK
Ensembl hg19 (Hinxton)ENSG00000125755 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125755 [Gene_View]  chr19:45815442-45863290 [Contig_View]  SYMPK [Vega]
ICGC DataPortalENSG00000125755
TCGA cBioPortalSYMPK
AceView (NCBI)SYMPK
Genatlas (Paris)SYMPK
WikiGenes8189
SOURCE (Princeton)SYMPK
Genetics Home Reference (NIH)SYMPK
Genomic and cartography
GoldenPath hg38 (UCSC)SYMPK  -     chr19:45815442-45863290 -  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYMPK  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblSYMPK - 19q13.32 [CytoView hg19]  SYMPK - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBISYMPK [Mapview hg19]  SYMPK [Mapview hg38]
OMIM602388   
Gene and transcription
Genbank (Entrez)AB209024 AB210010 AF049526 AK130602 AK300252
RefSeq transcript (Entrez)NM_004819
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYMPK
Cluster EST : UnigeneHs.515475 [ NCBI ]
CGAP (NCI)Hs.515475
Alternative Splicing GalleryENSG00000125755
Gene ExpressionSYMPK [ NCBI-GEO ]   SYMPK [ EBI - ARRAY_EXPRESS ]   SYMPK [ SEEK ]   SYMPK [ MEM ]
Gene Expression Viewer (FireBrowse)SYMPK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8189
GTEX Portal (Tissue expression)SYMPK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92797   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92797  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92797
Splice isoforms : SwissVarQ92797
PhosPhoSitePlusQ92797
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Symplekin/Pta1    Symplekin/Pta1_N    Symplekin_C   
Domain families : Pfam (Sanger)DUF3453 (PF11935)    Symplekin_C (PF12295)   
Domain families : Pfam (NCBI)pfam11935    pfam12295   
Conserved Domain (NCBI)SYMPK
DMDM Disease mutations8189
Blocks (Seattle)SYMPK
PDB (SRS)3O2Q    3O2S    3O2T    3ODR    3ODS    4H3H    4H3K   
PDB (PDBSum)3O2Q    3O2S    3O2T    3ODR    3ODS    4H3H    4H3K   
PDB (IMB)3O2Q    3O2S    3O2T    3ODR    3ODS    4H3H    4H3K   
PDB (RSDB)3O2Q    3O2S    3O2T    3ODR    3ODS    4H3H    4H3K   
Structural Biology KnowledgeBase3O2Q    3O2S    3O2T    3ODR    3ODS    4H3H    4H3K   
SCOP (Structural Classification of Proteins)3O2Q    3O2S    3O2T    3ODR    3ODS    4H3H    4H3K   
CATH (Classification of proteins structures)3O2Q    3O2S    3O2T    3ODR    3ODS    4H3H    4H3K   
SuperfamilyQ92797
Human Protein AtlasENSG00000125755
Peptide AtlasQ92797
HPRD09090
IPIIPI00023344   IPI00413614   IPI00556574   IPI00816255   IPI01015275   
Protein Interaction databases
DIP (DOE-UCLA)Q92797
IntAct (EBI)Q92797
FunCoupENSG00000125755
BioGRIDSYMPK
STRING (EMBL)SYMPK
ZODIACSYMPK
Ontologies - Pathways
QuickGOQ92797
Ontology : AmiGOmRNA splicing, via spliceosome  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytoskeleton  plasma membrane  bicellular tight junction  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA export from nucleus  cell adhesion  mRNA 3'-end processing  positive regulation of protein dephosphorylation  nuclear stress granule  
Ontology : EGO-EBImRNA splicing, via spliceosome  protein binding  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytoskeleton  plasma membrane  bicellular tight junction  termination of RNA polymerase II transcription  mRNA polyadenylation  mRNA export from nucleus  cell adhesion  mRNA 3'-end processing  positive regulation of protein dephosphorylation  nuclear stress granule  
Pathways : KEGGmRNA surveillance pathway    Tight junction   
NDEx NetworkSYMPK
Atlas of Cancer Signalling NetworkSYMPK
Wikipedia pathwaysSYMPK
Orthology - Evolution
OrthoDB8189
GeneTree (enSembl)ENSG00000125755
Phylogenetic Trees/Animal Genes : TreeFamSYMPK
HOVERGENQ92797
HOGENOMQ92797
Homologs : HomoloGeneSYMPK
Homology/Alignments : Family Browser (UCSC)SYMPK
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYMPK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYMPK
dbVarSYMPK
ClinVarSYMPK
1000_GenomesSYMPK 
Exome Variant ServerSYMPK
ExAC (Exome Aggregation Consortium)SYMPK (select the gene name)
Genetic variants : HAPMAP8189
Genomic Variants (DGV)SYMPK [DGVbeta]
DECIPHERSYMPK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYMPK 
Mutations
ICGC Data PortalSYMPK 
TCGA Data PortalSYMPK 
Broad Tumor PortalSYMPK
OASIS PortalSYMPK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYMPK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYMPK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYMPK
DgiDB (Drug Gene Interaction Database)SYMPK
DoCM (Curated mutations)SYMPK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYMPK (select a term)
intoGenSYMPK
Cancer3DSYMPK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602388   
Orphanet
MedgenSYMPK
Genetic Testing Registry SYMPK
NextProtQ92797 [Medical]
TSGene8189
GENETestsSYMPK
Target ValidationSYMPK
Huge Navigator SYMPK [HugePedia]
snp3D : Map Gene to Disease8189
BioCentury BCIQSYMPK
ClinGenSYMPK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8189
Chemical/Pharm GKB GenePA134896920
Clinical trialSYMPK
Miscellaneous
canSAR (ICR)SYMPK (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYMPK
EVEXSYMPK
GoPubMedSYMPK
iHOPSYMPK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:40:49 CEST 2017

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