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SYN1 (synapsin I)

Identity

Other aliasSYN1a
SYN1b
SYNI
HGNC (Hugo) SYN1
LocusID (NCBI) 6853
Atlas_Id 51752
Location Xp11.3  [Link to chromosome band Xp11]
Location_base_pair Starts at 47571901 and ends at 47619857 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAM120B (6q27) / SYN1 (Xp11.23)FARP1 (13q32.2) / SYN1 (Xp11.23)SYN1 (Xp11.23) / ADAMTS2 (5q35.3)
SYN1 (Xp11.23) / ALDOC (17q11.2)SYN1 (Xp11.23) / ATAD1 (10q23.31)SYN1 (Xp11.23) / DUSP3 (17q21.31)
SYN1 (Xp11.23) / GAB1 (4q31.21)SYN1 (Xp11.23) / GM2A (5q33.1)SYN1 (Xp11.23) / PDGFRB (5q32)
SYN1 (Xp11.23) / RDH14 (2p24.2)SYN1 (Xp11.23) / SYN1 (Xp11.23)SYN1 Xp11.23 / ATAD1 10q23.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SYN1   11494
Cards
Entrez_Gene (NCBI)SYN1  6853  synapsin I
AliasesSYN1a; SYN1b; SYNI
GeneCards (Weizmann)SYN1
Ensembl hg19 (Hinxton)ENSG00000008056 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000008056 [Gene_View]  chrX:47571901-47619857 [Contig_View]  SYN1 [Vega]
ICGC DataPortalENSG00000008056
TCGA cBioPortalSYN1
AceView (NCBI)SYN1
Genatlas (Paris)SYN1
WikiGenes6853
SOURCE (Princeton)SYN1
Genetics Home Reference (NIH)SYN1
Genomic and cartography
GoldenPath hg38 (UCSC)SYN1  -     chrX:47571901-47619857 -  Xp11.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYN1  -     Xp11.3   [Description]    (hg19-Feb_2009)
EnsemblSYN1 - Xp11.3 [CytoView hg19]  SYN1 - Xp11.3 [CytoView hg38]
Mapping of homologs : NCBISYN1 [Mapview hg19]  SYN1 [Mapview hg38]
OMIM300491   313440   
Gene and transcription
Genbank (Entrez)AI929645 AL833961 BC036711 BC048799
RefSeq transcript (Entrez)NM_006950 NM_133499
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYN1
Cluster EST : UnigeneHs.225936 [ NCBI ]
CGAP (NCI)Hs.225936
Alternative Splicing GalleryENSG00000008056
Gene ExpressionSYN1 [ NCBI-GEO ]   SYN1 [ EBI - ARRAY_EXPRESS ]   SYN1 [ SEEK ]   SYN1 [ MEM ]
Gene Expression Viewer (FireBrowse)SYN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6853
GTEX Portal (Tissue expression)SYN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17600   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17600  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17600
Splice isoforms : SwissVarP17600
PhosPhoSitePlusP17600
Domaine pattern : Prosite (Expaxy)SYNAPSIN_1 (PS00415)    SYNAPSIN_2 (PS00416)   
Domains : Interpro (EBI)ATP_grasp_subdomain_1    ATP_grasp_subdomain_2    PreATP-grasp_dom    SYN1    Synapsin    Synapsin_ATP-bd_dom    Synapsin_CS    Synapsin_P_site    Synapsin_pre-ATP-grasp_dom   
Domain families : Pfam (Sanger)Synapsin (PF02078)    Synapsin_C (PF02750)    Synapsin_N (PF10581)   
Domain families : Pfam (NCBI)pfam02078    pfam02750    pfam10581   
Conserved Domain (NCBI)SYN1
DMDM Disease mutations6853
Blocks (Seattle)SYN1
SuperfamilyP17600
Human Protein AtlasENSG00000008056
Peptide AtlasP17600
HPRD02433
IPIIPI00300568   IPI00251507   
Protein Interaction databases
DIP (DOE-UCLA)P17600
IntAct (EBI)P17600
FunCoupENSG00000008056
BioGRIDSYN1
STRING (EMBL)SYN1
ZODIACSYN1
Ontologies - Pathways
QuickGOP17600
Ontology : AmiGOsynaptonemal complex  actin binding  catalytic activity  transporter activity  protein binding  ATP binding  Golgi apparatus  cytosol  chemical synaptic transmission  neurotransmitter secretion  synaptic vesicle  postsynaptic density  protein kinase binding  cell junction  dendrite  terminal bouton  myelin sheath  regulation of neurotransmitter secretion  calcium-dependent protein binding  presynaptic active zone  synaptic vesicle clustering  anchored component of synaptic vesicle membrane  regulation of synaptic vesicle exocytosis  
Ontology : EGO-EBIsynaptonemal complex  actin binding  catalytic activity  transporter activity  protein binding  ATP binding  Golgi apparatus  cytosol  chemical synaptic transmission  neurotransmitter secretion  synaptic vesicle  postsynaptic density  protein kinase binding  cell junction  dendrite  terminal bouton  myelin sheath  regulation of neurotransmitter secretion  calcium-dependent protein binding  presynaptic active zone  synaptic vesicle clustering  anchored component of synaptic vesicle membrane  regulation of synaptic vesicle exocytosis  
NDEx NetworkSYN1
Atlas of Cancer Signalling NetworkSYN1
Wikipedia pathwaysSYN1
Orthology - Evolution
OrthoDB6853
GeneTree (enSembl)ENSG00000008056
Phylogenetic Trees/Animal Genes : TreeFamSYN1
HOVERGENP17600
HOGENOMP17600
Homologs : HomoloGeneSYN1
Homology/Alignments : Family Browser (UCSC)SYN1
Gene fusions - Rearrangements
Fusion : MitelmanSYN1/ATAD1 [Xp11.23/10q23.31]  
Fusion: TCGASYN1 Xp11.23 ATAD1 10q23.31 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYN1
dbVarSYN1
ClinVarSYN1
1000_GenomesSYN1 
Exome Variant ServerSYN1
ExAC (Exome Aggregation Consortium)SYN1 (select the gene name)
Genetic variants : HAPMAP6853
Genomic Variants (DGV)SYN1 [DGVbeta]
DECIPHERSYN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYN1 
Mutations
ICGC Data PortalSYN1 
TCGA Data PortalSYN1 
Broad Tumor PortalSYN1
OASIS PortalSYN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch SYN1
DgiDB (Drug Gene Interaction Database)SYN1
DoCM (Curated mutations)SYN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYN1 (select a term)
intoGenSYN1
Cancer3DSYN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300491    313440   
Orphanet11684   
MedgenSYN1
Genetic Testing Registry SYN1
NextProtP17600 [Medical]
TSGene6853
GENETestsSYN1
Huge Navigator SYN1 [HugePedia]
snp3D : Map Gene to Disease6853
BioCentury BCIQSYN1
ClinGenSYN1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6853
Chemical/Pharm GKB GenePA36276
Clinical trialSYN1
Miscellaneous
canSAR (ICR)SYN1 (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYN1
EVEXSYN1
GoPubMedSYN1
iHOPSYN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:39:56 CEST 2017

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