Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SYN3 (synapsin III)

Identity

Other alias-
HGNC (Hugo) SYN3
LocusID (NCBI) 8224
Atlas_Id 49902
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 32512553 and ends at 33058391 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADORA2B (17p12) / SYN3 (22q12.3)DDX24 (14q32.12) / SYN3 (22q12.3)FGF12 (3q28) / SYN3 (22q12.3)
HUWE1 (Xp11.22) / SYN3 (22q12.3)LRRC75A-AS1 (17p11.2) / SYN3 (22q12.3)RHOB (2p24.1) / SYN3 (22q12.3)
SYN3 (22q12.3) / ERVW-1 ()SYN3 (22q12.3) / GRAPL (17p11.2)SYN3 (22q12.3) / HAPLN3 (15q26.1)
SYN3 (22q12.3) / PRKDC (8q11.21)SYN3 (22q12.3) / SYN3 (22q12.3)SYN3 (22q12.3) / ZBTB24 (6q21)
ADORA2B 17p12 / SYN3 22q12.3FGF12 3q28 / SYN3 22q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SYN3   11496
Cards
Entrez_Gene (NCBI)SYN3  8224  synapsin III
Aliases
GeneCards (Weizmann)SYN3
Ensembl hg19 (Hinxton)ENSG00000185666 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185666 [Gene_View]  chr22:32512553-33058391 [Contig_View]  SYN3 [Vega]
ICGC DataPortalENSG00000185666
TCGA cBioPortalSYN3
AceView (NCBI)SYN3
Genatlas (Paris)SYN3
WikiGenes8224
SOURCE (Princeton)SYN3
Genetics Home Reference (NIH)SYN3
Genomic and cartography
GoldenPath hg38 (UCSC)SYN3  -     chr22:32512553-33058391 -  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYN3  -     22q12.3   [Description]    (hg19-Feb_2009)
EnsemblSYN3 - 22q12.3 [CytoView hg19]  SYN3 - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBISYN3 [Mapview hg19]  SYN3 [Mapview hg38]
OMIM602705   
Gene and transcription
Genbank (Entrez)AB209684 AF046873 AI095028 AK300171 BC075065
RefSeq transcript (Entrez)NM_001135774 NM_003490 NM_133632 NM_133633
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYN3
Cluster EST : UnigeneHs.608750 [ NCBI ]
CGAP (NCI)Hs.608750
Alternative Splicing GalleryENSG00000185666
Gene ExpressionSYN3 [ NCBI-GEO ]   SYN3 [ EBI - ARRAY_EXPRESS ]   SYN3 [ SEEK ]   SYN3 [ MEM ]
Gene Expression Viewer (FireBrowse)SYN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8224
GTEX Portal (Tissue expression)SYN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14994   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14994  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14994
Splice isoforms : SwissVarO14994
PhosPhoSitePlusO14994
Domaine pattern : Prosite (Expaxy)SYNAPSIN_1 (PS00415)    SYNAPSIN_2 (PS00416)   
Domains : Interpro (EBI)ATP_grasp_subdomain_1    ATP_grasp_subdomain_2    PreATP-grasp_dom    SYN3    Synapsin    Synapsin_ATP-bd_dom    Synapsin_CS    Synapsin_P_site    Synapsin_pre-ATP-grasp_dom   
Domain families : Pfam (Sanger)Synapsin (PF02078)    Synapsin_C (PF02750)    Synapsin_N (PF10581)   
Domain families : Pfam (NCBI)pfam02078    pfam02750    pfam10581   
Conserved Domain (NCBI)SYN3
DMDM Disease mutations8224
Blocks (Seattle)SYN3
PDB (SRS)2P0A   
PDB (PDBSum)2P0A   
PDB (IMB)2P0A   
PDB (RSDB)2P0A   
Structural Biology KnowledgeBase2P0A   
SCOP (Structural Classification of Proteins)2P0A   
CATH (Classification of proteins structures)2P0A   
SuperfamilyO14994
Human Protein AtlasENSG00000185666
Peptide AtlasO14994
HPRD04083
IPIIPI00298984   IPI00910273   IPI00913983   IPI00373789   IPI00873310   
Protein Interaction databases
DIP (DOE-UCLA)O14994
IntAct (EBI)O14994
FunCoupENSG00000185666
BioGRIDSYN3
STRING (EMBL)SYN3
ZODIACSYN3
Ontologies - Pathways
QuickGOO14994
Ontology : AmiGOcatalytic activity  ATP binding  neurotransmitter secretion  synaptic vesicle  postsynaptic density  cell junction  synaptic vesicle membrane  regulation of synaptic transmission, GABAergic  
Ontology : EGO-EBIcatalytic activity  ATP binding  neurotransmitter secretion  synaptic vesicle  postsynaptic density  cell junction  synaptic vesicle membrane  regulation of synaptic transmission, GABAergic  
NDEx NetworkSYN3
Atlas of Cancer Signalling NetworkSYN3
Wikipedia pathwaysSYN3
Orthology - Evolution
OrthoDB8224
GeneTree (enSembl)ENSG00000185666
Phylogenetic Trees/Animal Genes : TreeFamSYN3
HOVERGENO14994
HOGENOMO14994
Homologs : HomoloGeneSYN3
Homology/Alignments : Family Browser (UCSC)SYN3
Gene fusions - Rearrangements
Fusion : MitelmanADORA2B/SYN3 [17p12/22q12.3]  [t(17;22)(p12;q12)]  
Fusion : MitelmanFGF12/SYN3 [3q28/22q12.3]  [t(3;22)(q29;q12)]  
Fusion: TCGAADORA2B 17p12 SYN3 22q12.3 BLCA
Fusion: TCGAFGF12 3q28 SYN3 22q12.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYN3
dbVarSYN3
ClinVarSYN3
1000_GenomesSYN3 
Exome Variant ServerSYN3
ExAC (Exome Aggregation Consortium)SYN3 (select the gene name)
Genetic variants : HAPMAP8224
Genomic Variants (DGV)SYN3 [DGVbeta]
DECIPHERSYN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYN3 
Mutations
ICGC Data PortalSYN3 
TCGA Data PortalSYN3 
Broad Tumor PortalSYN3
OASIS PortalSYN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYN3
DgiDB (Drug Gene Interaction Database)SYN3
DoCM (Curated mutations)SYN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYN3 (select a term)
intoGenSYN3
Cancer3DSYN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602705   
Orphanet
MedgenSYN3
Genetic Testing Registry SYN3
NextProtO14994 [Medical]
TSGene8224
GENETestsSYN3
Target ValidationSYN3
Huge Navigator SYN3 [HugePedia]
snp3D : Map Gene to Disease8224
BioCentury BCIQSYN3
ClinGenSYN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8224
Chemical/Pharm GKB GenePA36278
Clinical trialSYN3
Miscellaneous
canSAR (ICR)SYN3 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYN3
EVEXSYN3
GoPubMedSYN3
iHOPSYN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:33:54 CEST 2017

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