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SYNE2 (spectrin repeat containing nuclear envelope protein 2)

Identity

Alias (NCBI)EDMD5
KASH2
NUA
NUANCE
Nesp2
Nesprin-2
SYNE-2
TROPH
HGNC (Hugo) SYNE2
HGNC Alias symbSYNE-2
DKFZP434H2235
Nesprin-2
NUANCE
NUA
KIAA1011
Nesp2
HGNC Alias namenuclear envelope spectrin repeat-2
 nucleus and actin connecting element
HGNC Previous namespectrin repeat containing, nuclear envelope 2
LocusID (NCBI) 23224
Atlas_Id 51353
Location 14q23.2  [Link to chromosome band 14q23]
Location_base_pair Starts at 63852965 and ends at 64226451 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LIN52 (14q24.3) / SYNE2 (14q23.2)MTHFD1 (14q23.3) / SYNE2 (14q23.2)OSTF1 (9q21.13) / SYNE2 (14q23.2)
SPRED2 (2p14) / SYNE2 (14q23.2)SYNE2 (14q23.2) / ACTN1 (14q24.1)SYNE2 (14q23.2) / CATSPERB (14q32.12)
SYNE2 (14q23.2) / DMRTA1 (9p21.3)SYNE2 (14q23.2) / ITPK1 (14q32.12)SYNE2 (14q23.2) / KIAA0391 (14q13.2)
SYNE2 (14q23.2) / MIPOL1 (14q13.3)SYNE2 (14q23.2) / MUC12 (7q22.1)SYNE2 (14q23.2) / NAPEPLD (7q22.1)
SYNE2 (14q23.2) / RTN1 (14q23.1)SYNE2 (14q23.2) / SP110 (2q37.1)SYNE2 (14q23.2) / SYNE2 (14q23.2)
LIN52 14q24.3 / SYNE2 14q23.2SYNE2 14q23.2 / ACTN1 14q24.1SYNE2 14q23.2 / CATSPERB 14q32.12
SYNE2 14q23.2 / DMRTA1 9p21.3SYNE2 14q23.2 / ITPK1 14q32.12SYNE2 14q23.2 / KIAA0391 14q13.2
SYNE2 14q23.2 / MIPOL1 14q13.3SYNE2 14q23.2 / RTN1 14q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;14)(q23;q32) TTC7B/SYNE2


External links

Nomenclature
HGNC (Hugo)SYNE2   17084
LRG (Locus Reference Genomic)LRG_872
Cards
Entrez_Gene (NCBI)SYNE2    spectrin repeat containing nuclear envelope protein 2
AliasesEDMD5; KASH2; NUA; NUANCE; 
Nesp2; Nesprin-2; SYNE-2; TROPH
GeneCards (Weizmann)SYNE2
Ensembl hg19 (Hinxton)ENSG00000054654 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000054654 [Gene_View]  ENSG00000054654 [Sequence]  chr14:63852965-64226451 [Contig_View]  SYNE2 [Vega]
ICGC DataPortalENSG00000054654
TCGA cBioPortalSYNE2
AceView (NCBI)SYNE2
Genatlas (Paris)SYNE2
SOURCE (Princeton)SYNE2
Genetics Home Reference (NIH)SYNE2
Genomic and cartography
GoldenPath hg38 (UCSC)SYNE2  -     chr14:63852965-64226451 +  14q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYNE2  -     14q23.2   [Description]    (hg19-Feb_2009)
GoldenPathSYNE2 - 14q23.2 [CytoView hg19]  SYNE2 - 14q23.2 [CytoView hg38]
ImmunoBaseENSG00000054654
Genome Data Viewer NCBISYNE2 [Mapview hg19]  
OMIM608442   612999   
Gene and transcription
Genbank (Entrez)AB023228 AF357236 AF435010 AF435011 AF495911
RefSeq transcript (Entrez)NM_015180 NM_182910 NM_182912 NM_182913 NM_182914
Consensus coding sequences : CCDS (NCBI)SYNE2
Gene ExpressionSYNE2 [ NCBI-GEO ]   SYNE2 [ EBI - ARRAY_EXPRESS ]   SYNE2 [ SEEK ]   SYNE2 [ MEM ]
Gene Expression Viewer (FireBrowse)SYNE2 [ Firebrowse - Broad ]
GenevisibleExpression of SYNE2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23224
GTEX Portal (Tissue expression)SYNE2
Human Protein AtlasENSG00000054654-SYNE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)SYNE2
Human Protein Atlas [tissue]ENSG00000054654-SYNE2 [tissue]
HPRD09763
Protein Interaction databases
BioGRIDSYNE2
STRING (EMBL)SYNE2
ZODIACSYNE2
Ontologies - Pathways
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSYNE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:00 CEST 2021

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