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SYNE3 (spectrin repeat containing, nuclear envelope family member 3)

Identity

Alias_namesC14orf49
chromosome 14 open reading frame 49
Alias_symbol (synonym)FLJ25605
NET53
Nesprin-3
Nesp3
Other alias
HGNC (Hugo) SYNE3
LocusID (NCBI) 161176
Atlas_Id 74413
Location 14q32.13  [Link to chromosome band 14q32]
Location_base_pair Starts at 95883831 and ends at 95942173 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAM19A5 (22q13.32) / SYNE3 (14q32.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SYNE3   19861
Cards
Entrez_Gene (NCBI)SYNE3  161176  spectrin repeat containing, nuclear envelope family member 3
AliasesC14orf49; NET53; Nesp3
GeneCards (Weizmann)SYNE3
Ensembl hg19 (Hinxton)ENSG00000176438 [Gene_View]  chr14:95883831-95942173 [Contig_View]  SYNE3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000176438 [Gene_View]  chr14:95883831-95942173 [Contig_View]  SYNE3 [Vega]
ICGC DataPortalENSG00000176438
TCGA cBioPortalSYNE3
AceView (NCBI)SYNE3
Genatlas (Paris)SYNE3
WikiGenes161176
SOURCE (Princeton)SYNE3
Genetics Home Reference (NIH)SYNE3
Genomic and cartography
GoldenPath hg19 (UCSC)SYNE3  -     chr14:95883831-95942173 -  14q32.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SYNE3  -     14q32.13   [Description]    (hg38-Dec_2013)
EnsemblSYNE3 - 14q32.13 [CytoView hg19]  SYNE3 - 14q32.13 [CytoView hg38]
Mapping of homologs : NCBISYNE3 [Mapview hg19]  SYNE3 [Mapview hg38]
OMIM610861   
Gene and transcription
Genbank (Entrez)AK098471 AK131436 BC061899 BC146604 BM701154
RefSeq transcript (Entrez)NM_152592
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)SYNE3
Cluster EST : UnigeneHs.354645 [ NCBI ]
CGAP (NCI)Hs.354645
Alternative Splicing GalleryENSG00000176438
Gene ExpressionSYNE3 [ NCBI-GEO ]   SYNE3 [ EBI - ARRAY_EXPRESS ]   SYNE3 [ SEEK ]   SYNE3 [ MEM ]
Gene Expression Viewer (FireBrowse)SYNE3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)161176
GTEX Portal (Tissue expression)SYNE3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMZ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMZ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMZ3
Splice isoforms : SwissVarQ6ZMZ3
PhosPhoSitePlusQ6ZMZ3
Domaine pattern : Prosite (Expaxy)KASH (PS51049)   
Domains : Interpro (EBI)KASH    Spectrin/alpha-actinin    Spectrin_repeat    SYNE3   
Domain families : Pfam (Sanger)KASH (PF10541)    Spectrin (PF00435)   
Domain families : Pfam (NCBI)pfam10541    pfam00435   
Domain families : Smart (EMBL)SPEC (SM00150)  
Conserved Domain (NCBI)SYNE3
DMDM Disease mutations161176
Blocks (Seattle)SYNE3
SuperfamilyQ6ZMZ3
Human Protein AtlasENSG00000176438
Peptide AtlasQ6ZMZ3
HPRD12652
IPIIPI00394994   IPI00829842   IPI00830100   IPI00441296   IPI01025192   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMZ3
IntAct (EBI)Q6ZMZ3
FunCoupENSG00000176438
BioGRIDSYNE3
STRING (EMBL)SYNE3
ZODIACSYNE3
Ontologies - Pathways
QuickGOQ6ZMZ3
Ontology : AmiGOprotein binding  nuclear envelope  nuclear outer membrane  rough endoplasmic reticulum  cytoskeleton organization  regulation of cell shape  membrane  integral component of membrane  LINC complex  actin filament binding  establishment of protein localization to membrane  cytoskeletal anchoring at nuclear membrane  
Ontology : EGO-EBIprotein binding  nuclear envelope  nuclear outer membrane  rough endoplasmic reticulum  cytoskeleton organization  regulation of cell shape  membrane  integral component of membrane  LINC complex  actin filament binding  establishment of protein localization to membrane  cytoskeletal anchoring at nuclear membrane  
NDEx NetworkSYNE3
Atlas of Cancer Signalling NetworkSYNE3
Wikipedia pathwaysSYNE3
Orthology - Evolution
OrthoDB161176
GeneTree (enSembl)ENSG00000176438
Phylogenetic Trees/Animal Genes : TreeFamSYNE3
HOVERGENQ6ZMZ3
HOGENOMQ6ZMZ3
Homologs : HomoloGeneSYNE3
Homology/Alignments : Family Browser (UCSC)SYNE3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYNE3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYNE3
dbVarSYNE3
ClinVarSYNE3
1000_GenomesSYNE3 
Exome Variant ServerSYNE3
ExAC (Exome Aggregation Consortium)SYNE3 (select the gene name)
Genetic variants : HAPMAP161176
Genomic Variants (DGV)SYNE3 [DGVbeta]
DECIPHER (Syndromes)14:95883831-95942173  ENSG00000176438
CONAN: Copy Number AnalysisSYNE3 
Mutations
ICGC Data PortalSYNE3 
TCGA Data PortalSYNE3 
Broad Tumor PortalSYNE3
OASIS PortalSYNE3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYNE3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYNE3
BioMutasearch SYNE3
DgiDB (Drug Gene Interaction Database)SYNE3
DoCM (Curated mutations)SYNE3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYNE3 (select a term)
intoGenSYNE3
Cancer3DSYNE3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610861   
Orphanet
MedgenSYNE3
Genetic Testing Registry SYNE3
NextProtQ6ZMZ3 [Medical]
TSGene161176
GENETestsSYNE3
Huge Navigator SYNE3 [HugePedia]
snp3D : Map Gene to Disease161176
BioCentury BCIQSYNE3
ClinGenSYNE3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD161176
Chemical/Pharm GKB GenePA134931380
Clinical trialSYNE3
Miscellaneous
canSAR (ICR)SYNE3 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYNE3
EVEXSYNE3
GoPubMedSYNE3
iHOPSYNE3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:47:13 CET 2017

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