SYNE3 (spectrin repeat containing nuclear envelope family member 3)

2017-10-01  

Identity

HGNC
SYNE3
LOCATION
14q32.13
LOCUSID
161176
ALIAS
C14orf139,C14orf49,KASH3,LINC00341,NCRNA00341,NET53,Nesp3

Other Information

Locus ID:

NCBI: 161176
MIM: 610861
HGNC: 19861
Ensembl: ENSG00000176438

Variants:

dbSNP: 161176
ClinVar: 161176
TCGA: ENSG00000176438
COSMIC: SYNE3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176438ENST00000334258Q6ZMZ3
ENSG00000176438ENST00000553340Q6ZMZ3
ENSG00000176438ENST00000554873G3V533
ENSG00000176438ENST00000557275Q6ZMZ3

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
188270152008TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.87
219377182011Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization.42
285002532017LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1.17
281464292017Relationship between LINC00341 expression and cancer prognosis.4
299011142018Sperm‑associated antigen 4 (SPAG4) as a new cancer marker interacts with Nesprin3 to regulate cell migration in lung carcinoma.1

Citation

Dessen P

SYNE3 (spectrin repeat containing nuclear envelope family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57098/syne3