SYNM (synemin)

2007-02-01  

Identity

HGNC
LOCATION
15q26.3
LOCUSID
ALIAS
DMN,SYN
FUSION GENES

Other Information

Locus ID:

NCBI: 23336
MIM: 606087
HGNC: 24466
Ensembl: ENSG00000182253

Variants:

dbSNP: 23336
ClinVar: 23336
TCGA: ENSG00000182253
COSMIC: SYNM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182253ENST00000328642C9JIE4
ENSG00000182253ENST00000336292O15061
ENSG00000182253ENST00000560674H0YL34
ENSG00000182253ENST00000594047A0A075B7B1

Expression (GTEx)

0
500
1000
1500

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167770712006Interactions of intermediate filament protein synemin with dystrophin and utrophin.30
205438602010Intermediate filament dynamics and breast cancer: aberrant promoter methylation of the Synemin gene is associated with early tumor relapse.22
183428542008Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin.20
180280342008Human alpha-synemin interacts directly with vinculin and metavinculin.19
156579402005Intermediate filament protein synemin is present in human reactive and malignant astrocytes and associates with ruffled membranes in astrocytoma cells.16
274705162016Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.13
198536012010Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration.11
223377732012Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A.10
235943592014Synemin is expressed in reactive astrocytes and Rosenthal fibers in Alexander disease.9
126692402003Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseases.7

Citation

Dessen P

SYNM (synemin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50031/synm