Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SYT11 (synaptotagmin 11)

Identity

Alias_namessynaptotagmin XI
Alias_symbol (synonym)KIAA0080
MGC10881
MGC17226
DKFZp781D015
Other aliasSYT12
sytXI
HGNC (Hugo) SYT11
LocusID (NCBI) 23208
Atlas_Id 55828
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 155859469 and ends at 155885199 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LMNA (1q22) / SYT11 (1q22)PI4KB (1q21.3) / SYT11 (1q22)SEPT11 (4q21.1) / SYT11 (1q22)
SYT11 (1q22) / HMGB1 (13q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SYT11   19239
Cards
Entrez_Gene (NCBI)SYT11  23208  synaptotagmin 11
AliasesSYT12; sytXI
GeneCards (Weizmann)SYT11
Ensembl hg19 (Hinxton)ENSG00000132718 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132718 [Gene_View]  chr1:155859469-155885199 [Contig_View]  SYT11 [Vega]
ICGC DataPortalENSG00000132718
TCGA cBioPortalSYT11
AceView (NCBI)SYT11
Genatlas (Paris)SYT11
WikiGenes23208
SOURCE (Princeton)SYT11
Genetics Home Reference (NIH)SYT11
Genomic and cartography
GoldenPath hg38 (UCSC)SYT11  -     chr1:155859469-155885199 +  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYT11  -     1q22   [Description]    (hg19-Feb_2009)
EnsemblSYT11 - 1q22 [CytoView hg19]  SYT11 - 1q22 [CytoView hg38]
Mapping of homologs : NCBISYT11 [Mapview hg19]  SYT11 [Mapview hg38]
OMIM608741   
Gene and transcription
Genbank (Entrez)AA824539 AK026178 AK027540 AK074931 AK296378
RefSeq transcript (Entrez)NM_152280
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYT11
Cluster EST : UnigeneHs.32984 [ NCBI ]
CGAP (NCI)Hs.32984
Alternative Splicing GalleryENSG00000132718
Gene ExpressionSYT11 [ NCBI-GEO ]   SYT11 [ EBI - ARRAY_EXPRESS ]   SYT11 [ SEEK ]   SYT11 [ MEM ]
Gene Expression Viewer (FireBrowse)SYT11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23208
GTEX Portal (Tissue expression)SYT11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BT88   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BT88  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BT88
Splice isoforms : SwissVarQ9BT88
PhosPhoSitePlusQ9BT88
Domaine pattern : Prosite (Expaxy)C2 (PS50004)   
Domains : Interpro (EBI)C2_dom    Synaptotagmin    SYT11   
Domain families : Pfam (Sanger)C2 (PF00168)   
Domain families : Pfam (NCBI)pfam00168   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)SYT11
DMDM Disease mutations23208
Blocks (Seattle)SYT11
SuperfamilyQ9BT88
Human Protein AtlasENSG00000132718
Peptide AtlasQ9BT88
HPRD12289
IPIIPI00027875   IPI01011725   
Protein Interaction databases
DIP (DOE-UCLA)Q9BT88
IntAct (EBI)Q9BT88
FunCoupENSG00000132718
BioGRIDSYT11
STRING (EMBL)SYT11
ZODIACSYT11
Ontologies - Pathways
QuickGOQ9BT88
Ontology : AmiGOplasma membrane repair  phagocytic cup  calcium ion binding  calcium ion binding  protein binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  lysosome  plasma membrane  integral component of plasma membrane  vesicle fusion  synaptic vesicle  synaptic vesicle  postsynaptic density  regulation of calcium ion-dependent exocytosis  syntaxin binding  cell junction  clathrin binding  axon  synaptic vesicle membrane  translation initiation factor binding  ubiquitin protein ligase binding  early phagosome  protein homodimerization activity  neuron projection  terminal bouton  dendritic spine  cell body  phagocytic vesicle  negative regulation of neurotransmitter secretion  perinuclear region of cytoplasm  beta-tubulin binding  presynaptic active zone membrane  calcium ion-regulated exocytosis of neurotransmitter  negative regulation of phagocytosis  protein homotetramerization  recycling endosome  excitatory synapse  inhibitory synapse  presynapse  negative regulation of interleukin-6 secretion  negative regulation of synaptic vesicle endocytosis  regulation of defense response to bacterium  negative regulation of tumor necrosis factor secretion  negative regulation of membrane invagination  regulation of phagosome maturation  positive regulation of protein localization to phagocytic vesicle  negative regulation of clathrin-coated pit assembly  calcium ion regulated lysosome exocytosis  
Ontology : EGO-EBIplasma membrane repair  phagocytic cup  calcium ion binding  calcium ion binding  protein binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  lysosome  plasma membrane  integral component of plasma membrane  vesicle fusion  synaptic vesicle  synaptic vesicle  postsynaptic density  regulation of calcium ion-dependent exocytosis  syntaxin binding  cell junction  clathrin binding  axon  synaptic vesicle membrane  translation initiation factor binding  ubiquitin protein ligase binding  early phagosome  protein homodimerization activity  neuron projection  terminal bouton  dendritic spine  cell body  phagocytic vesicle  negative regulation of neurotransmitter secretion  perinuclear region of cytoplasm  beta-tubulin binding  presynaptic active zone membrane  calcium ion-regulated exocytosis of neurotransmitter  negative regulation of phagocytosis  protein homotetramerization  recycling endosome  excitatory synapse  inhibitory synapse  presynapse  negative regulation of interleukin-6 secretion  negative regulation of synaptic vesicle endocytosis  regulation of defense response to bacterium  negative regulation of tumor necrosis factor secretion  negative regulation of membrane invagination  regulation of phagosome maturation  positive regulation of protein localization to phagocytic vesicle  negative regulation of clathrin-coated pit assembly  calcium ion regulated lysosome exocytosis  
NDEx NetworkSYT11
Atlas of Cancer Signalling NetworkSYT11
Wikipedia pathwaysSYT11
Orthology - Evolution
OrthoDB23208
GeneTree (enSembl)ENSG00000132718
Phylogenetic Trees/Animal Genes : TreeFamSYT11
HOVERGENQ9BT88
HOGENOMQ9BT88
Homologs : HomoloGeneSYT11
Homology/Alignments : Family Browser (UCSC)SYT11
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYT11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYT11
dbVarSYT11
ClinVarSYT11
1000_GenomesSYT11 
Exome Variant ServerSYT11
ExAC (Exome Aggregation Consortium)SYT11 (select the gene name)
Genetic variants : HAPMAP23208
Genomic Variants (DGV)SYT11 [DGVbeta]
DECIPHERSYT11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYT11 
Mutations
ICGC Data PortalSYT11 
TCGA Data PortalSYT11 
Broad Tumor PortalSYT11
OASIS PortalSYT11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYT11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYT11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYT11
DgiDB (Drug Gene Interaction Database)SYT11
DoCM (Curated mutations)SYT11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYT11 (select a term)
intoGenSYT11
Cancer3DSYT11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608741   
Orphanet
MedgenSYT11
Genetic Testing Registry SYT11
NextProtQ9BT88 [Medical]
TSGene23208
GENETestsSYT11
Huge Navigator SYT11 [HugePedia]
snp3D : Map Gene to Disease23208
BioCentury BCIQSYT11
ClinGenSYT11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23208
Chemical/Pharm GKB GenePA134898675
Clinical trialSYT11
Miscellaneous
canSAR (ICR)SYT11 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYT11
EVEXSYT11
GoPubMedSYT11
iHOPSYT11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:40:00 CEST 2017

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