SYT11 (synaptotagmin 11)

2016-08-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
SYT12,sytXI
FUSION GENES

Other Information

Locus ID:

NCBI: 23208
MIM: 608741
HGNC: 19239
Ensembl: ENSG00000132718

Variants:

dbSNP: 23208
ClinVar: 23208
TCGA: ENSG00000132718
COSMIC: SYT11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132718ENST00000368324Q9BT88

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129255692003The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI.52
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
272788222016The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway.37
171929562007Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia.11
293116852018Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.8
153543862004Screening for mutations in synaptotagmin XI in Parkinson's disease.2
241646542014Genetic variants of synaptic vesicle and presynaptic plasma membrane proteins in idiopathic generalized epilepsy.2
269441712016Synaptotagmin XI in Parkinson's disease: New evidence from an association study in Spain and Mexico.2

Citation

Dessen P

SYT11 (synaptotagmin 11)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55828/syt11