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SYT2 (synaptotagmin 2)

Identity

Alias_namessynaptotagmin II
Other aliasCMS7
MYSPC
SytII
HGNC (Hugo) SYT2
LocusID (NCBI) 127833
Atlas_Id 56525
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 202590597 and ends at 202643453 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCT3 (1q22) / SYT2 (1q32.1)PPFIA4 (1q32.1) / SYT2 (1q32.1)SYT2 (1q32.1) / MYO7A (11q13.5)
SYT2 (1q32.1) / PPFIA4 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SYT2   11510
Cards
Entrez_Gene (NCBI)SYT2  127833  synaptotagmin 2
AliasesCMS7; MYSPC; SytII
GeneCards (Weizmann)SYT2
Ensembl hg19 (Hinxton)ENSG00000143858 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143858 [Gene_View]  chr1:202590597-202643453 [Contig_View]  SYT2 [Vega]
ICGC DataPortalENSG00000143858
TCGA cBioPortalSYT2
AceView (NCBI)SYT2
Genatlas (Paris)SYT2
WikiGenes127833
SOURCE (Princeton)SYT2
Genetics Home Reference (NIH)SYT2
Genomic and cartography
GoldenPath hg38 (UCSC)SYT2  -     chr1:202590597-202643453 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYT2  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblSYT2 - 1q32.1 [CytoView hg19]  SYT2 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBISYT2 [Mapview hg19]  SYT2 [Mapview hg38]
OMIM600104   616040   
Gene and transcription
Genbank (Entrez)AK090672 AK094430 AK124510 BC100814 BC100815
RefSeq transcript (Entrez)NM_001136504 NM_177402
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYT2
Cluster EST : UnigeneHs.25422 [ NCBI ]
CGAP (NCI)Hs.25422
Alternative Splicing GalleryENSG00000143858
Gene ExpressionSYT2 [ NCBI-GEO ]   SYT2 [ EBI - ARRAY_EXPRESS ]   SYT2 [ SEEK ]   SYT2 [ MEM ]
Gene Expression Viewer (FireBrowse)SYT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)127833
GTEX Portal (Tissue expression)SYT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N9I0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N9I0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N9I0
Splice isoforms : SwissVarQ8N9I0
PhosPhoSitePlusQ8N9I0
Domaine pattern : Prosite (Expaxy)C2 (PS50004)   
Domains : Interpro (EBI)C2_dom    Synaptotagmin    Synaptotagmin1/2   
Domain families : Pfam (Sanger)C2 (PF00168)   
Domain families : Pfam (NCBI)pfam00168   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)SYT2
DMDM Disease mutations127833
Blocks (Seattle)SYT2
SuperfamilyQ8N9I0
Human Protein AtlasENSG00000143858
Peptide AtlasQ8N9I0
HPRD02520
IPIIPI00219274   
Protein Interaction databases
DIP (DOE-UCLA)Q8N9I0
IntAct (EBI)Q8N9I0
FunCoupENSG00000143858
BioGRIDSYT2
STRING (EMBL)SYT2
ZODIACSYT2
Ontologies - Pathways
QuickGOQ8N9I0
Ontology : AmiGOcalcium ion binding  protein binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  plasma membrane  plasma membrane  vesicle fusion  synaptic vesicle  integral component of membrane  regulation of calcium ion-dependent exocytosis  syntaxin binding  cell junction  clathrin binding  clathrin-coated vesicle membrane  synaptic vesicle membrane  synaptic vesicle membrane  chromaffin granule membrane  inositol 1,3,4,5 tetrakisphosphate binding  synaptic vesicle endocytosis  calcium ion-regulated exocytosis of neurotransmitter  membrane organization  positive regulation of dendrite extension  
Ontology : EGO-EBIcalcium ion binding  protein binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  plasma membrane  plasma membrane  vesicle fusion  synaptic vesicle  integral component of membrane  regulation of calcium ion-dependent exocytosis  syntaxin binding  cell junction  clathrin binding  clathrin-coated vesicle membrane  synaptic vesicle membrane  synaptic vesicle membrane  chromaffin granule membrane  inositol 1,3,4,5 tetrakisphosphate binding  synaptic vesicle endocytosis  calcium ion-regulated exocytosis of neurotransmitter  membrane organization  positive regulation of dendrite extension  
NDEx NetworkSYT2
Atlas of Cancer Signalling NetworkSYT2
Wikipedia pathwaysSYT2
Orthology - Evolution
OrthoDB127833
GeneTree (enSembl)ENSG00000143858
Phylogenetic Trees/Animal Genes : TreeFamSYT2
HOVERGENQ8N9I0
HOGENOMQ8N9I0
Homologs : HomoloGeneSYT2
Homology/Alignments : Family Browser (UCSC)SYT2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYT2
dbVarSYT2
ClinVarSYT2
1000_GenomesSYT2 
Exome Variant ServerSYT2
ExAC (Exome Aggregation Consortium)SYT2 (select the gene name)
Genetic variants : HAPMAP127833
Genomic Variants (DGV)SYT2 [DGVbeta]
DECIPHERSYT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYT2 
Mutations
ICGC Data PortalSYT2 
TCGA Data PortalSYT2 
Broad Tumor PortalSYT2
OASIS PortalSYT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYT2
DgiDB (Drug Gene Interaction Database)SYT2
DoCM (Curated mutations)SYT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYT2 (select a term)
intoGenSYT2
Cancer3DSYT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600104    616040   
Orphanet13931   
MedgenSYT2
Genetic Testing Registry SYT2
NextProtQ8N9I0 [Medical]
TSGene127833
GENETestsSYT2
Target ValidationSYT2
Huge Navigator SYT2 [HugePedia]
snp3D : Map Gene to Disease127833
BioCentury BCIQSYT2
ClinGenSYT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD127833
Chemical/Pharm GKB GenePA36291
Clinical trialSYT2
Miscellaneous
canSAR (ICR)SYT2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYT2
EVEXSYT2
GoPubMedSYT2
iHOPSYT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:58:22 CEST 2017

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