Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SYT7 (synaptotagmin 7)

Identity

Alias_namesPCANAP7
prostate cancer associated protein 7
synaptotagmin VII
Alias_symbol (synonym)IPCA-7
SYT-VII
MGC150517
Other aliasIPCA7
SYTVII
HGNC (Hugo) SYT7
LocusID (NCBI) 9066
Atlas_Id 41658
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61513716 and ends at 61580872 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SF1 (11q13.1) / SYT7 (11q12.2)SYT7 (11q12.2) / KCNK4 (11q13.1)SYT7 (11q12.2) / PACS1 (11q13.1)
SYT7 (11q12.2) / PLA2G6 (22q13.1)SYT7 (11q12.2) / SNRPD3 (22q11.23)SYT7 (11q12.2) / WIPF2 (17q21.1)
UBR3 (2q31.1) / SYT7 (11q12.2)SF1 11q13.1 / SYT7 11q12.2SYT7 11q12.2 / PACS1 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(11;11)(q12;q13) SYT7/PACS1
t(11;11)(q12;q13) SF1/SYT7
t(11;11)(q12;q13) SYT7/KCNK4

External links

Nomenclature
HGNC (Hugo)SYT7   11514
Cards
Entrez_Gene (NCBI)SYT7  9066  synaptotagmin 7
AliasesIPCA-7; IPCA7; PCANAP7; SYT-VII; 
SYTVII
GeneCards (Weizmann)SYT7
Ensembl hg19 (Hinxton)ENSG00000011347 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011347 [Gene_View]  chr11:61513716-61580872 [Contig_View]  SYT7 [Vega]
ICGC DataPortalENSG00000011347
TCGA cBioPortalSYT7
AceView (NCBI)SYT7
Genatlas (Paris)SYT7
WikiGenes9066
SOURCE (Princeton)SYT7
Genetics Home Reference (NIH)SYT7
Genomic and cartography
GoldenPath hg38 (UCSC)SYT7  -     chr11:61513716-61580872 -  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYT7  -     11q12.2   [Description]    (hg19-Feb_2009)
EnsemblSYT7 - 11q12.2 [CytoView hg19]  SYT7 - 11q12.2 [CytoView hg38]
Mapping of homologs : NCBISYT7 [Mapview hg19]  SYT7 [Mapview hg38]
OMIM604146   
Gene and transcription
Genbank (Entrez)AF038535 AK294636 AL137559 BC042495 BC125170
RefSeq transcript (Entrez)NM_001252065 NM_001300773 NM_004200
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYT7
Cluster EST : UnigeneHs.684589 [ NCBI ]
CGAP (NCI)Hs.684589
Alternative Splicing GalleryENSG00000011347
Gene ExpressionSYT7 [ NCBI-GEO ]   SYT7 [ EBI - ARRAY_EXPRESS ]   SYT7 [ SEEK ]   SYT7 [ MEM ]
Gene Expression Viewer (FireBrowse)SYT7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9066
GTEX Portal (Tissue expression)SYT7
Human Protein AtlasENSG00000011347-SYT7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43581   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43581  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43581
Splice isoforms : SwissVarO43581
PhosPhoSitePlusO43581
Domaine pattern : Prosite (Expaxy)C2 (PS50004)   
Domains : Interpro (EBI)C2_dom    Synaptotagmin    Synaptotagmin7   
Domain families : Pfam (Sanger)C2 (PF00168)   
Domain families : Pfam (NCBI)pfam00168   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)SYT7
DMDM Disease mutations9066
Blocks (Seattle)SYT7
PDB (SRS)2D8K   
PDB (PDBSum)2D8K   
PDB (IMB)2D8K   
PDB (RSDB)2D8K   
Structural Biology KnowledgeBase2D8K   
SCOP (Structural Classification of Proteins)2D8K   
CATH (Classification of proteins structures)2D8K   
SuperfamilyO43581
Human Protein Atlas [tissue]ENSG00000011347-SYT7 [tissue]
Peptide AtlasO43581
HPRD11965
IPIIPI00012902   IPI00978799   IPI00745606   IPI01014982   IPI01015442   IPI01016059   IPI01013332   IPI01015502   IPI01014240   IPI01012979   
Protein Interaction databases
DIP (DOE-UCLA)O43581
IntAct (EBI)O43581
FunCoupENSG00000011347
BioGRIDSYT7
STRING (EMBL)SYT7
ZODIACSYT7
Ontologies - Pathways
QuickGOO43581
Ontology : AmiGOplasma membrane repair  phosphatidylserine binding  calcium ion binding  protein binding  calmodulin binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  phosphatidylinositol-4,5-bisphosphate binding  lysosome  lysosomal membrane  peroxisome  peroxisomal membrane  cytosol  plasma membrane  vesicle fusion  phagocytosis  synaptic vesicle  regulation of dopamine secretion  integral component of membrane  regulation of calcium ion-dependent exocytosis  syntaxin binding  cell junction  clathrin binding  dendrite  phagocytic vesicle membrane  synaptic vesicle membrane  dense core granule  early phagosome  synaptic vesicle recycling  presynaptic membrane  neuronal cell body  terminal bouton  positive regulation of calcium ion-dependent exocytosis  regulation of bone remodeling  calcium ion-regulated exocytosis of neurotransmitter  calcium ion-regulated exocytosis of neurotransmitter  regulation of phagocytosis  regulation of insulin secretion  extracellular exosome  regulation of glucagon secretion  vesicle-mediated cholesterol transport  phagosome-lysosome fusion  short-term synaptic potentiation  calcium ion regulated lysosome exocytosis  
Ontology : EGO-EBIplasma membrane repair  phosphatidylserine binding  calcium ion binding  protein binding  calmodulin binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  calcium-dependent phospholipid binding  phosphatidylinositol-4,5-bisphosphate binding  lysosome  lysosomal membrane  peroxisome  peroxisomal membrane  cytosol  plasma membrane  vesicle fusion  phagocytosis  synaptic vesicle  regulation of dopamine secretion  integral component of membrane  regulation of calcium ion-dependent exocytosis  syntaxin binding  cell junction  clathrin binding  dendrite  phagocytic vesicle membrane  synaptic vesicle membrane  dense core granule  early phagosome  synaptic vesicle recycling  presynaptic membrane  neuronal cell body  terminal bouton  positive regulation of calcium ion-dependent exocytosis  regulation of bone remodeling  calcium ion-regulated exocytosis of neurotransmitter  calcium ion-regulated exocytosis of neurotransmitter  regulation of phagocytosis  regulation of insulin secretion  extracellular exosome  regulation of glucagon secretion  vesicle-mediated cholesterol transport  phagosome-lysosome fusion  short-term synaptic potentiation  calcium ion regulated lysosome exocytosis  
NDEx NetworkSYT7
Atlas of Cancer Signalling NetworkSYT7
Wikipedia pathwaysSYT7
Orthology - Evolution
OrthoDB9066
GeneTree (enSembl)ENSG00000011347
Phylogenetic Trees/Animal Genes : TreeFamSYT7
HOVERGENO43581
HOGENOMO43581
Homologs : HomoloGeneSYT7
Homology/Alignments : Family Browser (UCSC)SYT7
Gene fusions - Rearrangements
Fusion : MitelmanSF1/SYT7 [11q13.1/11q12.2]  [t(11;11)(q12;q13)]  
Fusion : MitelmanSYT7/KCNK4 [11q12.2/11q13.1]  [t(11;11)(q12;q13)]  
Fusion : MitelmanSYT7/PACS1 [11q12.2/11q13.1]  [t(11;11)(q12;q13)]  
Fusion: TCGA_MDACCSF1 11q13.1 SYT7 11q12.2 LUAD
Fusion: TCGA_MDACCSYT7 11q12.2 PACS1 11q13.1 BRCA
Fusion PortalSF1 11q13.1 SYT7 11q12.2 LUAD
Fusion PortalSYT7 11q12.2 PACS1 11q13.1 BRCA
Fusion : QuiverSYT7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYT7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYT7
dbVarSYT7
ClinVarSYT7
1000_GenomesSYT7 
Exome Variant ServerSYT7
ExAC (Exome Aggregation Consortium)ENSG00000011347
GNOMAD BrowserENSG00000011347
Genetic variants : HAPMAP9066
Genomic Variants (DGV)SYT7 [DGVbeta]
DECIPHERSYT7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYT7 
Mutations
ICGC Data PortalSYT7 
TCGA Data PortalSYT7 
Broad Tumor PortalSYT7
OASIS PortalSYT7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYT7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYT7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYT7
DgiDB (Drug Gene Interaction Database)SYT7
DoCM (Curated mutations)SYT7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYT7 (select a term)
intoGenSYT7
Cancer3DSYT7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604146   
Orphanet
DisGeNETSYT7
MedgenSYT7
Genetic Testing Registry SYT7
NextProtO43581 [Medical]
TSGene9066
GENETestsSYT7
Target ValidationSYT7
Huge Navigator SYT7 [HugePedia]
snp3D : Map Gene to Disease9066
BioCentury BCIQSYT7
ClinGenSYT7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9066
Chemical/Pharm GKB GenePA36295
Clinical trialSYT7
Miscellaneous
canSAR (ICR)SYT7 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYT7
EVEXSYT7
GoPubMedSYT7
iHOPSYT7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon May 14 12:22:25 CEST 2018
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