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SYT8 (synaptotagmin 8)

Identity

Alias (NCBI)-
HGNC (Hugo) SYT8
HGNC Alias symbDKFZp434K0322
HGNC Previous namesynaptotagmin VIII
LocusID (NCBI) 90019
Atlas_Id 56495
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1834427 and ends at 1837521 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SYT8 (11p15.5) / TNNI2 (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  SYT8/TNNI2 (11p15)


External links

Nomenclature
HGNC (Hugo)SYT8   19264
Cards
Entrez_Gene (NCBI)SYT8  90019  synaptotagmin 8
Aliases
GeneCards (Weizmann)SYT8
Ensembl hg19 (Hinxton)ENSG00000149043 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149043 [Gene_View]  ENSG00000149043 [Sequence]  chr11:1834427-1837521 [Contig_View]  SYT8 [Vega]
ICGC DataPortalENSG00000149043
TCGA cBioPortalSYT8
AceView (NCBI)SYT8
Genatlas (Paris)SYT8
WikiGenes90019
SOURCE (Princeton)SYT8
Genetics Home Reference (NIH)SYT8
Genomic and cartography
GoldenPath hg38 (UCSC)SYT8  -     chr11:1834427-1837521 +  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYT8  -     11p15.5   [Description]    (hg19-Feb_2009)
GoldenPathSYT8 - 11p15.5 [CytoView hg19]  SYT8 - 11p15.5 [CytoView hg38]
ImmunoBaseENSG00000149043
genome Data Viewer NCBISYT8 [Mapview hg19]  
OMIM607719   
Gene and transcription
Genbank (Entrez)AK075202 AK131292 AK293395 AL137708 AY353087
RefSeq transcript (Entrez)NM_001290332 NM_001290333 NM_001290334 NM_138567
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYT8
Alternative Splicing GalleryENSG00000149043
Gene ExpressionSYT8 [ NCBI-GEO ]   SYT8 [ EBI - ARRAY_EXPRESS ]   SYT8 [ SEEK ]   SYT8 [ MEM ]
Gene Expression Viewer (FireBrowse)SYT8 [ Firebrowse - Broad ]
GenevisibleExpression of SYT8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90019
GTEX Portal (Tissue expression)SYT8
Human Protein AtlasENSG00000149043-SYT8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NBV8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NBV8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NBV8
Splice isoforms : SwissVarQ8NBV8
PhosPhoSitePlusQ8NBV8
Domaine pattern : Prosite (Expaxy)C2 (PS50004)   
Domains : Interpro (EBI)C2_dom    C2_domain_sf    Synaptotagmin    SYT8   
Domain families : Pfam (Sanger)C2 (PF00168)   
Domain families : Pfam (NCBI)pfam00168   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)SYT8
DMDM Disease mutations90019
Blocks (Seattle)SYT8
SuperfamilyQ8NBV8
Human Protein Atlas [tissue]ENSG00000149043-SYT8 [tissue]
Peptide AtlasQ8NBV8
HPRD09655
IPIIPI00301312   IPI00853594   IPI00953585   IPI00927128   IPI00646926   IPI00658080   IPI00853282   IPI00878634   
Protein Interaction databases
DIP (DOE-UCLA)Q8NBV8
IntAct (EBI)Q8NBV8
FunCoupENSG00000149043
BioGRIDSYT8
STRING (EMBL)SYT8
ZODIACSYT8
Ontologies - Pathways
QuickGOQ8NBV8
Ontology : AmiGOSNARE binding  acrosomal vesicle  phosphatidylserine binding  calcium ion binding  calcium-dependent phospholipid binding  plasma membrane  acrosome reaction  regulation of dopamine secretion  integral component of membrane  synaptic vesicle exocytosis  vesicle-mediated transport  calcium ion regulated exocytosis  regulation of calcium ion-dependent exocytosis  syntaxin binding  clathrin binding  axon  synaptic vesicle membrane  dense core granule  calcium-dependent protein binding  synaptic vesicle endocytosis  calcium ion-regulated exocytosis of neurotransmitter  exocytic vesicle  cellular response to calcium ion  
Ontology : EGO-EBISNARE binding  acrosomal vesicle  phosphatidylserine binding  calcium ion binding  calcium-dependent phospholipid binding  plasma membrane  acrosome reaction  regulation of dopamine secretion  integral component of membrane  synaptic vesicle exocytosis  vesicle-mediated transport  calcium ion regulated exocytosis  regulation of calcium ion-dependent exocytosis  syntaxin binding  clathrin binding  axon  synaptic vesicle membrane  dense core granule  calcium-dependent protein binding  synaptic vesicle endocytosis  calcium ion-regulated exocytosis of neurotransmitter  exocytic vesicle  cellular response to calcium ion  
NDEx NetworkSYT8
Atlas of Cancer Signalling NetworkSYT8
Wikipedia pathwaysSYT8
Orthology - Evolution
OrthoDB90019
GeneTree (enSembl)ENSG00000149043
Phylogenetic Trees/Animal Genes : TreeFamSYT8
HOGENOMQ8NBV8
Homologs : HomoloGeneSYT8
Homology/Alignments : Family Browser (UCSC)SYT8
Gene fusions - Rearrangements
Fusion : QuiverSYT8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYT8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYT8
dbVarSYT8
ClinVarSYT8
1000_GenomesSYT8 
Exome Variant ServerSYT8
GNOMAD BrowserENSG00000149043
Varsome BrowserSYT8
Genetic variants : HAPMAP90019
Genomic Variants (DGV)SYT8 [DGVbeta]
DECIPHERSYT8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYT8 
Mutations
ICGC Data PortalSYT8 
TCGA Data PortalSYT8 
Broad Tumor PortalSYT8
OASIS PortalSYT8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYT8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSYT8
Mutations and Diseases : HGMDSYT8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYT8
DgiDB (Drug Gene Interaction Database)SYT8
DoCM (Curated mutations)SYT8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYT8 (select a term)
intoGenSYT8
Cancer3DSYT8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607719   
Orphanet
DisGeNETSYT8
MedgenSYT8
Genetic Testing Registry SYT8
NextProtQ8NBV8 [Medical]
TSGene90019
GENETestsSYT8
Target ValidationSYT8
Huge Navigator SYT8 [HugePedia]
snp3D : Map Gene to Disease90019
BioCentury BCIQSYT8
ClinGenSYT8
Clinical trials, drugs, therapy
Protein Interactions : CTD90019
Pharm GKB GenePA134993261
Clinical trialSYT8
Miscellaneous
canSAR (ICR)SYT8 (select the gene name)
HarmonizomeSYT8
DataMed IndexSYT8
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYT8
EVEXSYT8
GoPubMedSYT8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:38:28 CEST 2020

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