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SYTL1 (synaptotagmin like 1)

Identity

Alias_namessynaptotagmin-like 1
Alias_symbol (synonym)SLP1
JFC1
FLJ14996
exophilin-7
Other alias
HGNC (Hugo) SYTL1
LocusID (NCBI) 84958
Atlas_Id 46454
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 27341992 and ends at 27353932 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C2CD3 (11q13.4) / SYTL1 (1p36.11)PLD2 (17p13.2) / SYTL1 (1p36.11)PSMC1 (14q32.11) / SYTL1 (1p36.11)
SYTL1 (1p36.11) / SYTL1 (1p36.11)SYTL1 (1p36.11) / WDTC1 (1p36.11)YTHDF2 (1p35.3) / SYTL1 (1p36.11)
C2CD3 11q13.4 / SYTL1 1p36.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SYTL1   15584
Cards
Entrez_Gene (NCBI)SYTL1  84958  synaptotagmin like 1
AliasesJFC1; SLP1
GeneCards (Weizmann)SYTL1
Ensembl hg19 (Hinxton)ENSG00000142765 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142765 [Gene_View]  chr1:27341992-27353932 [Contig_View]  SYTL1 [Vega]
ICGC DataPortalENSG00000142765
TCGA cBioPortalSYTL1
AceView (NCBI)SYTL1
Genatlas (Paris)SYTL1
WikiGenes84958
SOURCE (Princeton)SYTL1
Genetics Home Reference (NIH)SYTL1
Genomic and cartography
GoldenPath hg38 (UCSC)SYTL1  -     chr1:27341992-27353932 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYTL1  -     1p36.11   [Description]    (hg19-Feb_2009)
EnsemblSYTL1 - 1p36.11 [CytoView hg19]  SYTL1 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBISYTL1 [Mapview hg19]  SYTL1 [Mapview hg38]
OMIM608042   
Gene and transcription
Genbank (Entrez)AK027902 AK074154 AK096437 AK097172 AK126120
RefSeq transcript (Entrez)NM_001193308 NM_032872
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYTL1
Cluster EST : UnigeneHs.469175 [ NCBI ]
CGAP (NCI)Hs.469175
Alternative Splicing GalleryENSG00000142765
Gene ExpressionSYTL1 [ NCBI-GEO ]   SYTL1 [ EBI - ARRAY_EXPRESS ]   SYTL1 [ SEEK ]   SYTL1 [ MEM ]
Gene Expression Viewer (FireBrowse)SYTL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84958
GTEX Portal (Tissue expression)SYTL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYJ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYJ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYJ3
Splice isoforms : SwissVarQ8IYJ3
PhosPhoSitePlusQ8IYJ3
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    RABBD (PS50916)   
Domains : Interpro (EBI)C2_dom    Rab_BD    Sytl1    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)C2 (PF00168)   
Domain families : Pfam (NCBI)pfam00168   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)SYTL1
DMDM Disease mutations84958
Blocks (Seattle)SYTL1
SuperfamilyQ8IYJ3
Human Protein AtlasENSG00000142765
Peptide AtlasQ8IYJ3
IPIIPI00217789   IPI00154565   IPI00383054   IPI00384685   IPI00642934   IPI00514174   IPI00977269   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYJ3
IntAct (EBI)Q8IYJ3
FunCoupENSG00000142765
BioGRIDSYTL1
STRING (EMBL)SYTL1
ZODIACSYTL1
Ontologies - Pathways
QuickGOQ8IYJ3
Ontology : AmiGOcalcium ion binding  protein binding  calcium-dependent phospholipid binding  plasma membrane  intracellular protein transport  exocytosis  vesicle fusion  Rab GTPase binding  regulation of calcium ion-dependent exocytosis  extrinsic component of plasma membrane  syntaxin binding  clathrin binding  microvillus membrane  neurexin family protein binding  melanosome  calcium ion-regulated exocytosis of neurotransmitter  membrane organization  extracellular exosome  exocytic vesicle  presynapse  
Ontology : EGO-EBIcalcium ion binding  protein binding  calcium-dependent phospholipid binding  plasma membrane  intracellular protein transport  exocytosis  vesicle fusion  Rab GTPase binding  regulation of calcium ion-dependent exocytosis  extrinsic component of plasma membrane  syntaxin binding  clathrin binding  microvillus membrane  neurexin family protein binding  melanosome  calcium ion-regulated exocytosis of neurotransmitter  membrane organization  extracellular exosome  exocytic vesicle  presynapse  
NDEx NetworkSYTL1
Atlas of Cancer Signalling NetworkSYTL1
Wikipedia pathwaysSYTL1
Orthology - Evolution
OrthoDB84958
GeneTree (enSembl)ENSG00000142765
Phylogenetic Trees/Animal Genes : TreeFamSYTL1
HOVERGENQ8IYJ3
HOGENOMQ8IYJ3
Homologs : HomoloGeneSYTL1
Homology/Alignments : Family Browser (UCSC)SYTL1
Gene fusions - Rearrangements
Fusion : MitelmanC2CD3/SYTL1 [11q13.4/1p36.11]  [t(1;11)(p36;q13)]  
Fusion : MitelmanYTHDF2/SYTL1 [1p35.3/1p36.11]  [t(1;1)(p35;p36)]  
Fusion: TCGAC2CD3 11q13.4 SYTL1 1p36.11 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYTL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYTL1
dbVarSYTL1
ClinVarSYTL1
1000_GenomesSYTL1 
Exome Variant ServerSYTL1
ExAC (Exome Aggregation Consortium)SYTL1 (select the gene name)
Genetic variants : HAPMAP84958
Genomic Variants (DGV)SYTL1 [DGVbeta]
DECIPHERSYTL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYTL1 
Mutations
ICGC Data PortalSYTL1 
TCGA Data PortalSYTL1 
Broad Tumor PortalSYTL1
OASIS PortalSYTL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYTL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYTL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYTL1
DgiDB (Drug Gene Interaction Database)SYTL1
DoCM (Curated mutations)SYTL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYTL1 (select a term)
intoGenSYTL1
Cancer3DSYTL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608042   
Orphanet
MedgenSYTL1
Genetic Testing Registry SYTL1
NextProtQ8IYJ3 [Medical]
TSGene84958
GENETestsSYTL1
Target ValidationSYTL1
Huge Navigator SYTL1 [HugePedia]
snp3D : Map Gene to Disease84958
BioCentury BCIQSYTL1
ClinGenSYTL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84958
Chemical/Pharm GKB GenePA134921815
Clinical trialSYTL1
Miscellaneous
canSAR (ICR)SYTL1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYTL1
EVEXSYTL1
GoPubMedSYTL1
iHOPSYTL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:16:17 CEST 2017

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