Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SYTL2 (synaptotagmin like 2)

Identity

Alias_symbol (synonym)FLJ20163
FLJ21219
KIAA1597
exophilin-4
CHR11SYT
SLP2
SGA72M
MGC102768
PPP1R151
Other aliasEXO4
SLP2A
HGNC (Hugo) SYTL2
LocusID (NCBI) 54843
Atlas_Id 50549
Location 11q14.1  [Link to chromosome band 11q14]
Location_base_pair Starts at 85694221 and ends at 85719350 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SORL1 (11q24.1) / SYTL2 (11q14.1)SYTL2 (11q14.1) / CHRM1 (11q12.3)SYTL2 (11q14.1) / DOK5 (20q13.2)
SYTL2 (11q14.1) / PICALM (11q14.2)SYTL2 (11q14.1) / SYTL2 (11q14.1)SYTL2 (11q14.1) / TMEM135 (11q14.2)
ZNF782 (9q22.33) / SYTL2 (11q14.1)SORL1 11q24.1 / SYTL2 11q14.1SYTL2 11q14.1 / CHRM1 11q12.3
SYTL2 11q14.1 / DOK5 20q13.2SYTL2 11q14.1 / TMEM135 11q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(11;11)(q12;q14) SYTL2/CHRM1
t(11;11)(q14;q14) SYTL2/PICALM
t(11;11)(q14;q14) SYTL2/TMEM135
t(11;11)(q14;q24) SORL1/SYTL2
t(11;20)(q14;q13) SYTL2/DOK5

External links

Nomenclature
HGNC (Hugo)SYTL2   15585
Cards
Entrez_Gene (NCBI)SYTL2  54843  synaptotagmin like 2
AliasesCHR11SYT; EXO4; PPP1R151; SGA72M; 
SLP2; SLP2A
GeneCards (Weizmann)SYTL2
Ensembl hg19 (Hinxton)ENSG00000137501 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137501 [Gene_View]  chr11:85694221-85719350 [Contig_View]  SYTL2 [Vega]
ICGC DataPortalENSG00000137501
TCGA cBioPortalSYTL2
AceView (NCBI)SYTL2
Genatlas (Paris)SYTL2
WikiGenes54843
SOURCE (Princeton)SYTL2
Genetics Home Reference (NIH)SYTL2
Genomic and cartography
GoldenPath hg38 (UCSC)SYTL2  -     chr11:85694221-85719350 -  11q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYTL2  -     11q14.1   [Description]    (hg19-Feb_2009)
EnsemblSYTL2 - 11q14.1 [CytoView hg19]  SYTL2 - 11q14.1 [CytoView hg38]
Mapping of homologs : NCBISYTL2 [Mapview hg19]  SYTL2 [Mapview hg38]
OMIM612880   
Gene and transcription
Genbank (Entrez)AB046817 AI928445 AJ303364 AK000170 AK024872
RefSeq transcript (Entrez)NM_001162951 NM_001162952 NM_001162953 NM_001289608 NM_001289609 NM_001289610 NM_032379 NM_032943 NM_206927 NM_206928 NM_206929 NM_206930
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYTL2
Cluster EST : UnigeneHs.369520 [ NCBI ]
CGAP (NCI)Hs.369520
Alternative Splicing GalleryENSG00000137501
Gene ExpressionSYTL2 [ NCBI-GEO ]   SYTL2 [ EBI - ARRAY_EXPRESS ]   SYTL2 [ SEEK ]   SYTL2 [ MEM ]
Gene Expression Viewer (FireBrowse)SYTL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54843
GTEX Portal (Tissue expression)SYTL2
Human Protein AtlasENSG00000137501-SYTL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCH5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCH5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCH5
Splice isoforms : SwissVarQ9HCH5
PhosPhoSitePlusQ9HCH5
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    RABBD (PS50916)   
Domains : Interpro (EBI)C2_dom    Rab_BD    SYTL2    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)C2 (PF00168)    FYVE_2 (PF02318)   
Domain families : Pfam (NCBI)pfam00168    pfam02318   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)SYTL2
DMDM Disease mutations54843
Blocks (Seattle)SYTL2
PDB (SRS)3BC1   
PDB (PDBSum)3BC1   
PDB (IMB)3BC1   
PDB (RSDB)3BC1   
Structural Biology KnowledgeBase3BC1   
SCOP (Structural Classification of Proteins)3BC1   
CATH (Classification of proteins structures)3BC1   
SuperfamilyQ9HCH5
Human Protein Atlas [tissue]ENSG00000137501-SYTL2 [tissue]
Peptide AtlasQ9HCH5
HPRD10260
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCH5
IntAct (EBI)Q9HCH5
FunCoupENSG00000137501
BioGRIDSYTL2
STRING (EMBL)SYTL2
ZODIACSYTL2
Ontologies - Pathways
QuickGOQ9HCH5
Ontology : AmiGOphosphatidylserine binding  calcium ion binding  protein binding  calcium-dependent phospholipid binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  plasma membrane  intracellular protein transport  exocytosis  vesicle docking involved in exocytosis  vesicle fusion  negative regulation of phosphatase activity  membrane  vesicle-mediated transport  Rab GTPase binding  regulation of calcium ion-dependent exocytosis  extrinsic component of plasma membrane  phosphatase binding  syntaxin binding  clathrin binding  neurexin family protein binding  melanosome  calcium ion-regulated exocytosis of neurotransmitter  positive regulation of mucus secretion  exocytic vesicle  protein localization to plasma membrane  
Ontology : EGO-EBIphosphatidylserine binding  calcium ion binding  protein binding  calcium-dependent phospholipid binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  plasma membrane  intracellular protein transport  exocytosis  vesicle docking involved in exocytosis  vesicle fusion  negative regulation of phosphatase activity  membrane  vesicle-mediated transport  Rab GTPase binding  regulation of calcium ion-dependent exocytosis  extrinsic component of plasma membrane  phosphatase binding  syntaxin binding  clathrin binding  neurexin family protein binding  melanosome  calcium ion-regulated exocytosis of neurotransmitter  positive regulation of mucus secretion  exocytic vesicle  protein localization to plasma membrane  
NDEx NetworkSYTL2
Atlas of Cancer Signalling NetworkSYTL2
Wikipedia pathwaysSYTL2
Orthology - Evolution
OrthoDB54843
GeneTree (enSembl)ENSG00000137501
Phylogenetic Trees/Animal Genes : TreeFamSYTL2
HOVERGENQ9HCH5
HOGENOMQ9HCH5
Homologs : HomoloGeneSYTL2
Homology/Alignments : Family Browser (UCSC)SYTL2
Gene fusions - Rearrangements
Fusion : MitelmanSORL1/SYTL2 [11q24.1/11q14.1]  [t(11;11)(q14;q24)]  
Fusion : MitelmanSYTL2/CHRM1 [11q14.1/11q12.3]  [t(11;11)(q12;q14)]  
Fusion : MitelmanSYTL2/DOK5 [11q14.1/20q13.2]  [t(11;20)(q14;q13)]  
Fusion : MitelmanSYTL2/PICALM [11q14.1/11q14.2]  [t(11;11)(q14;q14)]  
Fusion : MitelmanSYTL2/TMEM135 [11q14.1/11q14.2]  [t(11;11)(q14;q14)]  
Fusion: TCGA_MDACCSORL1 11q24.1 SYTL2 11q14.1 LUAD
Fusion: TCGA_MDACCSYTL2 11q14.1 CHRM1 11q12.3 BRCA
Fusion: TCGA_MDACCSYTL2 11q14.1 DOK5 20q13.2 LUAD
Fusion: TCGA_MDACCSYTL2 11q14.1 TMEM135 11q14.2 BRCA
Fusion PortalSORL1 11q24.1 SYTL2 11q14.1 LUAD
Fusion PortalSYTL2 11q14.1 CHRM1 11q12.3 BRCA
Fusion PortalSYTL2 11q14.1 DOK5 20q13.2 LUAD
Fusion PortalSYTL2 11q14.1 TMEM135 11q14.2 BRCA
Fusion : QuiverSYTL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYTL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYTL2
dbVarSYTL2
ClinVarSYTL2
1000_GenomesSYTL2 
Exome Variant ServerSYTL2
ExAC (Exome Aggregation Consortium)ENSG00000137501
GNOMAD BrowserENSG00000137501
Genetic variants : HAPMAP54843
Genomic Variants (DGV)SYTL2 [DGVbeta]
DECIPHERSYTL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYTL2 
Mutations
ICGC Data PortalSYTL2 
TCGA Data PortalSYTL2 
Broad Tumor PortalSYTL2
OASIS PortalSYTL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYTL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYTL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYTL2
DgiDB (Drug Gene Interaction Database)SYTL2
DoCM (Curated mutations)SYTL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYTL2 (select a term)
intoGenSYTL2
Cancer3DSYTL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612880   
Orphanet
DisGeNETSYTL2
MedgenSYTL2
Genetic Testing Registry SYTL2
NextProtQ9HCH5 [Medical]
TSGene54843
GENETestsSYTL2
Target ValidationSYTL2
Huge Navigator SYTL2 [HugePedia]
snp3D : Map Gene to Disease54843
BioCentury BCIQSYTL2
ClinGenSYTL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54843
Chemical/Pharm GKB GenePA37985
Clinical trialSYTL2
Miscellaneous
canSAR (ICR)SYTL2 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYTL2
EVEXSYTL2
GoPubMedSYTL2
iHOPSYTL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:40:37 CET 2018
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