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SYTL3 (synaptotagmin like 3)

Identity

Alias_symbol (synonym)SLP3
exophilin-6
Other alias
HGNC (Hugo) SYTL3
LocusID (NCBI) 94120
Atlas_Id 56432
Location 6q25.3  [Link to chromosome band 6q25]
Location_base_pair Starts at 158663403 and ends at 158764876 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP85L (6q22.31) / SYTL3 (6q25.3)IGF2R (6q25.3) / SYTL3 (6q25.3)KMT2A (11q23.3) / SYTL3 (6q25.3)
SYTL3 (6q25.3) / PROSER1 (13q13.3)SYTL3 (6q25.3) / SYTL3 (6q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(q22;q25) CEP85L/SYTL3
IGF2R/SYTL3 (6q25)


External links

Nomenclature
HGNC (Hugo)SYTL3   15587
Cards
Entrez_Gene (NCBI)SYTL3  94120  synaptotagmin like 3
AliasesSLP3
GeneCards (Weizmann)SYTL3
Ensembl hg19 (Hinxton)ENSG00000164674 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164674 [Gene_View]  ENSG00000164674 [Sequence]  chr6:158663403-158764876 [Contig_View]  SYTL3 [Vega]
ICGC DataPortalENSG00000164674
TCGA cBioPortalSYTL3
AceView (NCBI)SYTL3
Genatlas (Paris)SYTL3
WikiGenes94120
SOURCE (Princeton)SYTL3
Genetics Home Reference (NIH)SYTL3
Genomic and cartography
GoldenPath hg38 (UCSC)SYTL3  -     chr6:158663403-158764876 +  6q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYTL3  -     6q25.3   [Description]    (hg19-Feb_2009)
EnsemblSYTL3 - 6q25.3 [CytoView hg19]  SYTL3 - 6q25.3 [CytoView hg38]
Mapping of homologs : NCBISYTL3 [Mapview hg19]  SYTL3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI674404 AK055750 AK092729 AK131092 AK298712
RefSeq transcript (Entrez)NM_001009991 NM_001242384 NM_001242394 NM_001242395 NM_001318745
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYTL3
Cluster EST : UnigeneHs.733155 [ NCBI ]
CGAP (NCI)Hs.733155
Alternative Splicing GalleryENSG00000164674
Gene ExpressionSYTL3 [ NCBI-GEO ]   SYTL3 [ EBI - ARRAY_EXPRESS ]   SYTL3 [ SEEK ]   SYTL3 [ MEM ]
Gene Expression Viewer (FireBrowse)SYTL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)94120
GTEX Portal (Tissue expression)SYTL3
Human Protein AtlasENSG00000164674-SYTL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4VX76   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4VX76  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4VX76
Splice isoforms : SwissVarQ4VX76
PhosPhoSitePlusQ4VX76
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    RABBD (PS50916)   
Domains : Interpro (EBI)C2_dom    C2_domain_sf    Rab_BD    SYTL3    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)C2 (PF00168)   
Domain families : Pfam (NCBI)pfam00168   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)SYTL3
DMDM Disease mutations94120
Blocks (Seattle)SYTL3
SuperfamilyQ4VX76
Human Protein Atlas [tissue]ENSG00000164674-SYTL3 [tissue]
Peptide AtlasQ4VX76
HPRD15462
IPIIPI00549512   IPI00477850   IPI01012968   IPI00748027   
Protein Interaction databases
DIP (DOE-UCLA)Q4VX76
IntAct (EBI)Q4VX76
FunCoupENSG00000164674
BioGRIDSYTL3
STRING (EMBL)SYTL3
ZODIACSYTL3
Ontologies - Pathways
QuickGOQ4VX76
Ontology : AmiGOcalcium-dependent phospholipid binding  intracellular protein transport  exocytosis  Rab GTPase binding  extrinsic component of plasma membrane  neurexin family protein binding  exocytic vesicle  
Ontology : EGO-EBIcalcium-dependent phospholipid binding  intracellular protein transport  exocytosis  Rab GTPase binding  extrinsic component of plasma membrane  neurexin family protein binding  exocytic vesicle  
NDEx NetworkSYTL3
Atlas of Cancer Signalling NetworkSYTL3
Wikipedia pathwaysSYTL3
Orthology - Evolution
OrthoDB94120
GeneTree (enSembl)ENSG00000164674
Phylogenetic Trees/Animal Genes : TreeFamSYTL3
HOVERGENQ4VX76
HOGENOMQ4VX76
Homologs : HomoloGeneSYTL3
Homology/Alignments : Family Browser (UCSC)SYTL3
Gene fusions - Rearrangements
Fusion : QuiverSYTL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYTL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYTL3
dbVarSYTL3
ClinVarSYTL3
1000_GenomesSYTL3 
Exome Variant ServerSYTL3
ExAC (Exome Aggregation Consortium)ENSG00000164674
GNOMAD BrowserENSG00000164674
Varsome BrowserSYTL3
Genetic variants : HAPMAP94120
Genomic Variants (DGV)SYTL3 [DGVbeta]
DECIPHERSYTL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYTL3 
Mutations
ICGC Data PortalSYTL3 
TCGA Data PortalSYTL3 
Broad Tumor PortalSYTL3
OASIS PortalSYTL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYTL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYTL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SYTL3
DgiDB (Drug Gene Interaction Database)SYTL3
DoCM (Curated mutations)SYTL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYTL3 (select a term)
intoGenSYTL3
Cancer3DSYTL3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETSYTL3
MedgenSYTL3
Genetic Testing Registry SYTL3
NextProtQ4VX76 [Medical]
TSGene94120
GENETestsSYTL3
Target ValidationSYTL3
Huge Navigator SYTL3 [HugePedia]
snp3D : Map Gene to Disease94120
BioCentury BCIQSYTL3
ClinGenSYTL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD94120
Chemical/Pharm GKB GenePA37986
Clinical trialSYTL3
Miscellaneous
canSAR (ICR)SYTL3 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYTL3
EVEXSYTL3
GoPubMedSYTL3
iHOPSYTL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:43:24 CET 2018

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