SYTL4 (synaptotagmin like 4)

2016-10-01  

Identity

HGNC
LOCATION
Xq22.1
LOCUSID
ALIAS
SLP4
FUSION GENES

Other Information

Locus ID:

NCBI: 94121
MIM: 300723
HGNC: 15588
Ensembl: ENSG00000102362

Variants:

dbSNP: 94121
ClinVar: 94121
TCGA: ENSG00000102362
COSMIC: SYTL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102362ENST00000263033Q96C24
ENSG00000102362ENST00000263033A0A024RCF8
ENSG00000102362ENST00000276141Q96C24
ENSG00000102362ENST00000276141A0A024RCF8
ENSG00000102362ENST00000372981Q96C24
ENSG00000102362ENST00000372989Q96C24
ENSG00000102362ENST00000372989A0A024RCF8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168318722006MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells.114
117730822002The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.54
265539292015Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.32
247007822014STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a.15
231402752013Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets.11
255952932015Insights into the molecular recognition of the granuphilin C2A domain with PI(4,5)P2.7
241846452014The C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids.5
270326722016Granuphilin exclusively mediates functional granule docking to the plasma membrane.4
319305962020Epstein-Barr virus-encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan-2 and synaptotagmin-like-4 in nasopharyngeal carcinoma cells.2
289060462017The unique N-terminal zinc finger of synaptotagmin-like protein 4 reveals FYVE structure.1

Citation

Dessen P

SYTL4 (synaptotagmin like 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56113/sytl4