Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SYTL4 (synaptotagmin like 4)

Identity

Other aliasSLP4
HGNC (Hugo) SYTL4
LocusID (NCBI) 94121
Atlas_Id 56113
Location Xq22.1  [Link to chromosome band Xq22]
Location_base_pair Starts at 100674491 and ends at 100732148 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
APC (5q22.2) / SYTL4 (Xq22.1)LHX6 (9q33.2) / SYTL4 (Xq22.1)SYTL4 (Xq22.1) / GPCPD1 (20p12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SYTL4   15588
Cards
Entrez_Gene (NCBI)SYTL4  94121  synaptotagmin like 4
AliasesSLP4
GeneCards (Weizmann)SYTL4
Ensembl hg19 (Hinxton)ENSG00000102362 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102362 [Gene_View]  chrX:100674491-100732148 [Contig_View]  SYTL4 [Vega]
ICGC DataPortalENSG00000102362
TCGA cBioPortalSYTL4
AceView (NCBI)SYTL4
Genatlas (Paris)SYTL4
WikiGenes94121
SOURCE (Princeton)SYTL4
Genetics Home Reference (NIH)SYTL4
Genomic and cartography
GoldenPath hg38 (UCSC)SYTL4  -     chrX:100674491-100732148 -  Xq22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SYTL4  -     Xq22.1   [Description]    (hg19-Feb_2009)
EnsemblSYTL4 - Xq22.1 [CytoView hg19]  SYTL4 - Xq22.1 [CytoView hg38]
Mapping of homologs : NCBISYTL4 [Mapview hg19]  SYTL4 [Mapview hg38]
OMIM300723   
Gene and transcription
Genbank (Entrez)AF302493 AK098279 AK292588 AK313086 AL832596
RefSeq transcript (Entrez)NM_001129896 NM_001174068 NM_080737
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SYTL4
Cluster EST : UnigeneHs.592224 [ NCBI ]
CGAP (NCI)Hs.592224
Alternative Splicing GalleryENSG00000102362
Gene ExpressionSYTL4 [ NCBI-GEO ]   SYTL4 [ EBI - ARRAY_EXPRESS ]   SYTL4 [ SEEK ]   SYTL4 [ MEM ]
Gene Expression Viewer (FireBrowse)SYTL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)94121
GTEX Portal (Tissue expression)SYTL4
Human Protein AtlasENSG00000102362-SYTL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96C24   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96C24  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96C24
Splice isoforms : SwissVarQ96C24
PhosPhoSitePlusQ96C24
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    RABBD (PS50916)   
Domains : Interpro (EBI)C2_dom    Rab_BD    Synaptotagmin    SYTL4    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)C2 (PF00168)    FYVE_2 (PF02318)   
Domain families : Pfam (NCBI)pfam00168    pfam02318   
Domain families : Smart (EMBL)C2 (SM00239)  
Conserved Domain (NCBI)SYTL4
DMDM Disease mutations94121
Blocks (Seattle)SYTL4
PDB (SRS)2CSZ    3FDW   
PDB (PDBSum)2CSZ    3FDW   
PDB (IMB)2CSZ    3FDW   
PDB (RSDB)2CSZ    3FDW   
Structural Biology KnowledgeBase2CSZ    3FDW   
SCOP (Structural Classification of Proteins)2CSZ    3FDW   
CATH (Classification of proteins structures)2CSZ    3FDW   
SuperfamilyQ96C24
Human Protein Atlas [tissue]ENSG00000102362-SYTL4 [tissue]
Peptide AtlasQ96C24
HPRD06735
IPIIPI01015206   IPI00639966   IPI00060201   
Protein Interaction databases
DIP (DOE-UCLA)Q96C24
IntAct (EBI)Q96C24
FunCoupENSG00000102362
BioGRIDSYTL4
STRING (EMBL)SYTL4
ZODIACSYTL4
Ontologies - Pathways
QuickGOQ96C24
Ontology : AmiGOplatelet degranulation  calcium ion binding  protein binding  phospholipid binding  calcium-dependent phospholipid binding  nucleoplasm  endosome  microtubule organizing center  cytosol  plasma membrane  plasma membrane  intracellular protein transport  vesicle fusion  Rab GTPase binding  regulation of calcium ion-dependent exocytosis  extrinsic component of membrane  syntaxin binding  secretory granule  clathrin binding  transport vesicle membrane  platelet alpha granule membrane  neurexin family protein binding  positive regulation of exocytosis  negative regulation of insulin secretion  calcium ion-regulated exocytosis of neurotransmitter  positive regulation of protein secretion  exocytic vesicle  multivesicular body sorting pathway  presynapse  
Ontology : EGO-EBIplatelet degranulation  calcium ion binding  protein binding  phospholipid binding  calcium-dependent phospholipid binding  nucleoplasm  endosome  microtubule organizing center  cytosol  plasma membrane  plasma membrane  intracellular protein transport  vesicle fusion  Rab GTPase binding  regulation of calcium ion-dependent exocytosis  extrinsic component of membrane  syntaxin binding  secretory granule  clathrin binding  transport vesicle membrane  platelet alpha granule membrane  neurexin family protein binding  positive regulation of exocytosis  negative regulation of insulin secretion  calcium ion-regulated exocytosis of neurotransmitter  positive regulation of protein secretion  exocytic vesicle  multivesicular body sorting pathway  presynapse  
NDEx NetworkSYTL4
Atlas of Cancer Signalling NetworkSYTL4
Wikipedia pathwaysSYTL4
Orthology - Evolution
OrthoDB94121
GeneTree (enSembl)ENSG00000102362
Phylogenetic Trees/Animal Genes : TreeFamSYTL4
HOVERGENQ96C24
HOGENOMQ96C24
Homologs : HomoloGeneSYTL4
Homology/Alignments : Family Browser (UCSC)SYTL4
Gene fusions - Rearrangements
Tumor Fusion PortalSYTL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSYTL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SYTL4
dbVarSYTL4
ClinVarSYTL4
1000_GenomesSYTL4 
Exome Variant ServerSYTL4
ExAC (Exome Aggregation Consortium)ENSG00000102362
GNOMAD BrowserENSG00000102362
Genetic variants : HAPMAP94121
Genomic Variants (DGV)SYTL4 [DGVbeta]
DECIPHERSYTL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSYTL4 
Mutations
ICGC Data PortalSYTL4 
TCGA Data PortalSYTL4 
Broad Tumor PortalSYTL4
OASIS PortalSYTL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSYTL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSYTL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch SYTL4
DgiDB (Drug Gene Interaction Database)SYTL4
DoCM (Curated mutations)SYTL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SYTL4 (select a term)
intoGenSYTL4
Cancer3DSYTL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300723   
Orphanet
DisGeNETSYTL4
MedgenSYTL4
Genetic Testing Registry SYTL4
NextProtQ96C24 [Medical]
TSGene94121
GENETestsSYTL4
Target ValidationSYTL4
Huge Navigator SYTL4 [HugePedia]
snp3D : Map Gene to Disease94121
BioCentury BCIQSYTL4
ClinGenSYTL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD94121
Chemical/Pharm GKB GenePA37987
Clinical trialSYTL4
Miscellaneous
canSAR (ICR)SYTL4 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSYTL4
EVEXSYTL4
GoPubMedSYTL4
iHOPSYTL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:37:30 CET 2017

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