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TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1)

Identity

Alias (NCBI)3'-Tab1
MAP3K7IP1
HGNC (Hugo) TAB1
HGNC Alias nameTAK1-binding protein 1
 mitogen-activated protein kinase kinase kinase 7 interacting protein 1
HGNC Previous nameMAP3K7IP1
HGNC Previous namemitogen-activated protein kinase kinase kinase 7 interacting protein 1
 TGF-beta activated kinase 1/MAP3K7 binding protein 1
LocusID (NCBI) 10454
Atlas_Id 51350
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 39399780 and ends at 39437130 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CACNA1I (22q13.1) / TAB1 (22q13.1)ITCH (20q11.22) / TAB1 (22q13.1)TAB1 (22q13.1) / MSL2 (3q22.3)
CACNA1I 22q13.1 / TAB1 22q13.1ITCH 20q11.22 / TAB1 22q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;19)(q32;q13) IGH/Various Partners


External links

 

Nomenclature
HGNC (Hugo)TAB1   18157
Cards
Entrez_Gene (NCBI)TAB1    TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Aliases3'-Tab1; MAP3K7IP1
GeneCards (Weizmann)TAB1
Ensembl hg19 (Hinxton)ENSG00000100324 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100324 [Gene_View]  ENSG00000100324 [Sequence]  chr22:39399780-39437130 [Contig_View]  TAB1 [Vega]
ICGC DataPortalENSG00000100324
TCGA cBioPortalTAB1
AceView (NCBI)TAB1
Genatlas (Paris)TAB1
SOURCE (Princeton)TAB1
Genetics Home Reference (NIH)TAB1
Genomic and cartography
GoldenPath hg38 (UCSC)TAB1  -     chr22:39399780-39437130 +  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAB1  -     22q13.1   [Description]    (hg19-Feb_2009)
GoldenPathTAB1 - 22q13.1 [CytoView hg19]  TAB1 - 22q13.1 [CytoView hg38]
ImmunoBaseENSG00000100324
Genome Data Viewer NCBITAB1 [Mapview hg19]  
OMIM602615   
Gene and transcription
Genbank (Entrez)AF425640 AI827837 AK291668 AK296314 AK308903
RefSeq transcript (Entrez)NM_006116 NM_153497
Consensus coding sequences : CCDS (NCBI)TAB1
Gene ExpressionTAB1 [ NCBI-GEO ]   TAB1 [ EBI - ARRAY_EXPRESS ]   TAB1 [ SEEK ]   TAB1 [ MEM ]
Gene Expression Viewer (FireBrowse)TAB1 [ Firebrowse - Broad ]
GenevisibleExpression of TAB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10454
GTEX Portal (Tissue expression)TAB1
Human Protein AtlasENSG00000100324-TAB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15750   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15750  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15750
PhosPhoSitePlusQ15750
Domaine pattern : Prosite (Expaxy)PPM_2 (PS51746)   
Domains : Interpro (EBI)PP2C    PPM-type_dom_sf    PPM-type_phosphatase_dom   
Domain families : Pfam (Sanger)PP2C (PF00481)   
Domain families : Pfam (NCBI)pfam00481   
Domain families : Smart (EMBL)PP2Cc (SM00332)  
Conserved Domain (NCBI)TAB1
PDB (RSDB)2J4O    2POM    2POP    2YDS    2YIY    4AY5    4AY6    4GS6    4KA3    4L3P    4L52    4L53    4O91    5DIY    5E7R    5GJD    5GJF    5GJG    5J7S    5J8I    5J9L    5JGA    5JGB    5JGD    5JH6    5JK3    5NZZ    5O90    5V5N    5VVU   
PDB Europe2J4O    2POM    2POP    2YDS    2YIY    4AY5    4AY6    4GS6    4KA3    4L3P    4L52    4L53    4O91    5DIY    5E7R    5GJD    5GJF    5GJG    5J7S    5J8I    5J9L    5JGA    5JGB    5JGD    5JH6    5JK3    5NZZ    5O90    5V5N    5VVU   
PDB (PDBSum)2J4O    2POM    2POP    2YDS    2YIY    4AY5    4AY6    4GS6    4KA3    4L3P    4L52    4L53    4O91    5DIY    5E7R    5GJD    5GJF    5GJG    5J7S    5J8I    5J9L    5JGA    5JGB    5JGD    5JH6    5JK3    5NZZ    5O90    5V5N    5VVU   
PDB (IMB)2J4O    2POM    2POP    2YDS    2YIY    4AY5    4AY6    4GS6    4KA3    4L3P    4L52    4L53    4O91    5DIY    5E7R    5GJD    5GJF    5GJG    5J7S    5J8I    5J9L    5JGA    5JGB    5JGD    5JH6    5JK3    5NZZ    5O90    5V5N    5VVU   
Structural Biology KnowledgeBase2J4O    2POM    2POP    2YDS    2YIY    4AY5    4AY6    4GS6    4KA3    4L3P    4L52    4L53    4O91    5DIY    5E7R    5GJD    5GJF    5GJG    5J7S    5J8I    5J9L    5JGA    5JGB    5JGD    5JH6    5JK3    5NZZ    5O90    5V5N    5VVU   
SCOP (Structural Classification of Proteins)2J4O    2POM    2POP    2YDS    2YIY    4AY5    4AY6    4GS6    4KA3    4L3P    4L52    4L53    4O91    5DIY    5E7R    5GJD    5GJF    5GJG    5J7S    5J8I    5J9L    5JGA    5JGB    5JGD    5JH6    5JK3    5NZZ    5O90    5V5N    5VVU   
CATH (Classification of proteins structures)2J4O    2POM    2POP    2YDS    2YIY    4AY5    4AY6    4GS6    4KA3    4L3P    4L52    4L53    4O91    5DIY    5E7R    5GJD    5GJF    5GJG    5J7S    5J8I    5J9L    5JGA    5JGB    5JGD    5JH6    5JK3    5NZZ    5O90    5V5N    5VVU   
SuperfamilyQ15750
AlphaFold pdb e-kbQ15750   
Human Protein Atlas [tissue]ENSG00000100324-TAB1 [tissue]
HPRD04012
Protein Interaction databases
DIP (DOE-UCLA)Q15750
IntAct (EBI)Q15750
BioGRIDTAB1
STRING (EMBL)TAB1
ZODIACTAB1
Ontologies - Pathways
QuickGOQ15750
Ontology : AmiGOactivation of MAPKKK activity  activation of MAPK activity  in utero embryonic development  stimulatory C-type lectin receptor signaling pathway  cytoplasmic pattern recognition receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  heart morphogenesis  cardiac septum development  protein serine/threonine phosphatase activity  protein binding  nucleus  cytosol  cytosol  cytosol  negative regulation of protein kinase activity  protein dephosphorylation  transforming growth factor beta receptor signaling pathway  I-kappaB kinase/NF-kappaB signaling  JNK cascade  enzyme activator activity  endosome membrane  protein deubiquitination  nuclear speck  kinase activator activity  lung development  protein-containing complex  aorta development  Fc-epsilon receptor signaling pathway  protein-containing complex binding  mitogen-activated protein kinase p38 binding  positive regulation of NF-kappaB transcription factor activity  coronary vasculature development  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  
Ontology : EGO-EBIactivation of MAPKKK activity  activation of MAPK activity  in utero embryonic development  stimulatory C-type lectin receptor signaling pathway  cytoplasmic pattern recognition receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  heart morphogenesis  cardiac septum development  protein serine/threonine phosphatase activity  protein binding  nucleus  cytosol  cytosol  cytosol  negative regulation of protein kinase activity  protein dephosphorylation  transforming growth factor beta receptor signaling pathway  I-kappaB kinase/NF-kappaB signaling  JNK cascade  enzyme activator activity  endosome membrane  protein deubiquitination  nuclear speck  kinase activator activity  lung development  protein-containing complex  aorta development  Fc-epsilon receptor signaling pathway  protein-containing complex binding  mitogen-activated protein kinase p38 binding  positive regulation of NF-kappaB transcription factor activity  coronary vasculature development  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  
Pathways : BIOCARTATGF beta signaling pathway [Genes]    Toll-Like Receptor Pathway [Genes]    Signal transduction through IL1R [Genes]    NF-kB Signaling Pathway [Genes]    WNT Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    NF-kappa B signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    TNF signaling pathway    Leishmaniasis    Toxoplasmosis    Herpes simplex infection    Epstein-Barr virus infection   
NDEx NetworkTAB1
Atlas of Cancer Signalling NetworkTAB1
Wikipedia pathwaysTAB1
Orthology - Evolution
OrthoDB10454
GeneTree (enSembl)ENSG00000100324
Phylogenetic Trees/Animal Genes : TreeFamTAB1
Homologs : HomoloGeneTAB1
Homology/Alignments : Family Browser (UCSC)TAB1
Gene fusions - Rearrangements
Fusion : MitelmanCACNA1I/TAB1 [22q13.1/22q13.1]  
Fusion : MitelmanITCH/TAB1 [20q11.22/22q13.1]  
Fusion : QuiverTAB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAB1
dbVarTAB1
ClinVarTAB1
MonarchTAB1
1000_GenomesTAB1 
Exome Variant ServerTAB1
GNOMAD BrowserENSG00000100324
Varsome BrowserTAB1
ACMGTAB1 variants
VarityQ15750
Genomic Variants (DGV)TAB1 [DGVbeta]
DECIPHERTAB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAB1 
Mutations
ICGC Data PortalTAB1 
TCGA Data PortalTAB1 
Broad Tumor PortalTAB1
OASIS PortalTAB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTAB1
Mutations and Diseases : HGMDTAB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTAB1
DgiDB (Drug Gene Interaction Database)TAB1
DoCM (Curated mutations)TAB1
CIViC (Clinical Interpretations of Variants in Cancer)TAB1
Cancer3DTAB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602615   
Orphanet
DisGeNETTAB1
MedgenTAB1
Genetic Testing Registry TAB1
NextProtQ15750 [Medical]
GENETestsTAB1
Target ValidationTAB1
Huge Navigator TAB1 [HugePedia]
ClinGenTAB1
Clinical trials, drugs, therapy
MyCancerGenomeTAB1
Protein Interactions : CTDTAB1
Pharm GKB GenePA30604
PharosQ15750
Clinical trialTAB1
Miscellaneous
canSAR (ICR)TAB1
HarmonizomeTAB1
DataMed IndexTAB1
Probes
Litterature
PubMed171 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTAB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:07 CEST 2021

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