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TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2)

Identity

Alias_namesMAP3K7IP2
mitogen-activated protein kinase kinase kinase 7 interacting protein 2
Alias_symbol (synonym)KIAA0733
Other aliasCHTD2
TAB-2
HGNC (Hugo) TAB2
LocusID (NCBI) 23118
Atlas_Id 43345
Location 6q25.1  [Link to chromosome band 6q25]
Location_base_pair Starts at 149318300 and ends at 149411613 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARF3 (12q13.12) / TAB2 (6q25.1)DUOX2 (15q21.1) / TAB2 (6q25.1)TAB2 (6q25.1) / PDE4D (5q11.2)
TAB2 (6q25.1) / SLC9B2 (4q24)TAB2 (6q25.1) / SLTM (15q22.1)TAB2 (6q25.1) / SMIM8 (6q15)
TAB2 (6q25.1) / TAB2 (6q25.1)TSNARE1 (8q24.3) / TAB2 (6q25.1)TAB2 6q25.1 C6orf162

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;12)(q25;q13) ARF3/TAB2


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q15;q25) TAB2/SMIM8


External links

Nomenclature
HGNC (Hugo)TAB2   17075
Cards
Entrez_Gene (NCBI)TAB2  23118  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
AliasesCHTD2; MAP3K7IP2; TAB-2
GeneCards (Weizmann)TAB2
Ensembl hg19 (Hinxton)ENSG00000055208 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000055208 [Gene_View]  ENSG00000055208 [Sequence]  chr6:149318300-149411613 [Contig_View]  TAB2 [Vega]
ICGC DataPortalENSG00000055208
TCGA cBioPortalTAB2
AceView (NCBI)TAB2
Genatlas (Paris)TAB2
WikiGenes23118
SOURCE (Princeton)TAB2
Genetics Home Reference (NIH)TAB2
Genomic and cartography
GoldenPath hg38 (UCSC)TAB2  -     chr6:149318300-149411613 +  6q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAB2  -     6q25.1   [Description]    (hg19-Feb_2009)
EnsemblTAB2 - 6q25.1 [CytoView hg19]  TAB2 - 6q25.1 [CytoView hg38]
Mapping of homologs : NCBITAB2 [Mapview hg19]  TAB2 [Mapview hg38]
OMIM605101   614980   
Gene and transcription
Genbank (Entrez)AB018276 AF241230 AI159838 AK025538 AK295750
RefSeq transcript (Entrez)NM_001292034 NM_001292035 NM_015093 NM_145342
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAB2
Cluster EST : UnigeneHs.520477 [ NCBI ]
CGAP (NCI)Hs.520477
Alternative Splicing GalleryENSG00000055208
Gene ExpressionTAB2 [ NCBI-GEO ]   TAB2 [ EBI - ARRAY_EXPRESS ]   TAB2 [ SEEK ]   TAB2 [ MEM ]
Gene Expression Viewer (FireBrowse)TAB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23118
GTEX Portal (Tissue expression)TAB2
Human Protein AtlasENSG00000055208-TAB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYJ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYJ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYJ8
Splice isoforms : SwissVarQ9NYJ8
PhosPhoSitePlusQ9NYJ8
Domaine pattern : Prosite (Expaxy)CUE (PS51140)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (EBI)CUE    Znf_RanBP2    Znf_RanBP2_sf   
Domain families : Pfam (Sanger)CUE (PF02845)   
Domain families : Pfam (NCBI)pfam02845   
Domain families : Smart (EMBL)CUE (SM00546)  ZnF_RBZ (SM00547)  
Conserved Domain (NCBI)TAB2
DMDM Disease mutations23118
Blocks (Seattle)TAB2
PDB (SRS)2DAE    2WWZ    2WX0    2WX1   
PDB (PDBSum)2DAE    2WWZ    2WX0    2WX1   
PDB (IMB)2DAE    2WWZ    2WX0    2WX1   
PDB (RSDB)2DAE    2WWZ    2WX0    2WX1   
Structural Biology KnowledgeBase2DAE    2WWZ    2WX0    2WX1   
SCOP (Structural Classification of Proteins)2DAE    2WWZ    2WX0    2WX1   
CATH (Classification of proteins structures)2DAE    2WWZ    2WX0    2WX1   
SuperfamilyQ9NYJ8
Human Protein Atlas [tissue]ENSG00000055208-TAB2 [tissue]
Peptide AtlasQ9NYJ8
HPRD05483
IPIIPI00419504   IPI00157561   IPI01010891   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYJ8
IntAct (EBI)Q9NYJ8
FunCoupENSG00000055208
BioGRIDTAB2
STRING (EMBL)TAB2
ZODIACTAB2
Ontologies - Pathways
QuickGOQ9NYJ8
Ontology : AmiGOactivation of MAPK activity  stimulatory C-type lectin receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  protein binding  nucleoplasm  cytosol  cytosol  plasma membrane  I-kappaB kinase/NF-kappaB signaling  JNK cascade  heart development  endosome membrane  negative regulation of autophagy  Fc-epsilon receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of protein kinase activity  metal ion binding  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  K63-linked polyubiquitin modification-dependent protein binding  
Ontology : EGO-EBIactivation of MAPK activity  stimulatory C-type lectin receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  protein binding  nucleoplasm  cytosol  cytosol  plasma membrane  I-kappaB kinase/NF-kappaB signaling  JNK cascade  heart development  endosome membrane  negative regulation of autophagy  Fc-epsilon receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of protein kinase activity  metal ion binding  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  K63-linked polyubiquitin modification-dependent protein binding  
Pathways : KEGGMAPK signaling pathway    NF-kappa B signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    TNF signaling pathway    Leishmaniasis    Toxoplasmosis    Measles    Herpes simplex infection    Epstein-Barr virus infection   
NDEx NetworkTAB2
Atlas of Cancer Signalling NetworkTAB2
Wikipedia pathwaysTAB2
Orthology - Evolution
OrthoDB23118
GeneTree (enSembl)ENSG00000055208
Phylogenetic Trees/Animal Genes : TreeFamTAB2
HOVERGENQ9NYJ8
HOGENOMQ9NYJ8
Homologs : HomoloGeneTAB2
Homology/Alignments : Family Browser (UCSC)TAB2
Gene fusions - Rearrangements
Fusion : MitelmanARF3/TAB2 [12q13.12/6q25.1]  [t(6;12)(q25;q13)]  
Fusion : MitelmanTAB2/SMIM8 [6q25.1/6q15]  [t(6;6)(q15;q25)]  
Fusion PortalTAB2 6q25.1 C6orf162 PRAD
Fusion : QuiverTAB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAB2
dbVarTAB2
ClinVarTAB2
1000_GenomesTAB2 
Exome Variant ServerTAB2
ExAC (Exome Aggregation Consortium)ENSG00000055208
GNOMAD BrowserENSG00000055208
Varsome BrowserTAB2
Genetic variants : HAPMAP23118
Genomic Variants (DGV)TAB2 [DGVbeta]
DECIPHERTAB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAB2 
Mutations
ICGC Data PortalTAB2 
TCGA Data PortalTAB2 
Broad Tumor PortalTAB2
OASIS PortalTAB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch TAB2
DgiDB (Drug Gene Interaction Database)TAB2
DoCM (Curated mutations)TAB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAB2 (select a term)
intoGenTAB2
Cancer3DTAB2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605101    614980   
Orphanet
DisGeNETTAB2
MedgenTAB2
Genetic Testing Registry TAB2
NextProtQ9NYJ8 [Medical]
TSGene23118
GENETestsTAB2
Target ValidationTAB2
Huge Navigator TAB2 [HugePedia]
snp3D : Map Gene to Disease23118
BioCentury BCIQTAB2
ClinGenTAB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23118
Chemical/Pharm GKB GenePA30605
Clinical trialTAB2
Miscellaneous
canSAR (ICR)TAB2 (select the gene name)
Probes
Litterature
PubMed152 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAB2
EVEXTAB2
GoPubMedTAB2
iHOPTAB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:43:26 CET 2018

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