Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TAC3 (tachykinin precursor 3)

Identity

Alias (NCBI)HH10
NK3
NKB
NKNB
PRO1155
ZNEUROK1
HGNC (Hugo) TAC3
HGNC Alias symbZNEUROK1
NKB
HGNC Alias namepreprotachykinin-B
HGNC Previous nameNKNB
HGNC Previous nameneuromedin K
 neurokinin beta
LocusID (NCBI) 6866
Atlas_Id 74455
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57009997 and ends at 57016560 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TAC3   11521
Cards
Entrez_Gene (NCBI)TAC3  6866  tachykinin precursor 3
AliasesHH10; NK3; NKB; NKNB; 
PRO1155; ZNEUROK1
GeneCards (Weizmann)TAC3
Ensembl hg19 (Hinxton)ENSG00000166863 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166863 [Gene_View]  ENSG00000166863 [Sequence]  chr12:57009997-57016560 [Contig_View]  TAC3 [Vega]
ICGC DataPortalENSG00000166863
TCGA cBioPortalTAC3
AceView (NCBI)TAC3
Genatlas (Paris)TAC3
WikiGenes6866
SOURCE (Princeton)TAC3
Genetics Home Reference (NIH)TAC3
Genomic and cartography
GoldenPath hg38 (UCSC)TAC3  -     chr12:57009997-57016560 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAC3  -     12q13.3   [Description]    (hg19-Feb_2009)
GoldenPathTAC3 - 12q13.3 [CytoView hg19]  TAC3 - 12q13.3 [CytoView hg38]
ImmunoBaseENSG00000166863
genome Data Viewer NCBITAC3 [Mapview hg19]  
OMIM162330   614839   
Gene and transcription
Genbank (Entrez)AF186112 AF216586 AF537113 AF537114 AF537115
RefSeq transcript (Entrez)NM_001006667 NM_001178054 NM_013251
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAC3
Alternative Splicing GalleryENSG00000166863
Gene ExpressionTAC3 [ NCBI-GEO ]   TAC3 [ EBI - ARRAY_EXPRESS ]   TAC3 [ SEEK ]   TAC3 [ MEM ]
Gene Expression Viewer (FireBrowse)TAC3 [ Firebrowse - Broad ]
GenevisibleExpression of TAC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6866
GTEX Portal (Tissue expression)TAC3
Human Protein AtlasENSG00000166863-TAC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHF0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHF0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHF0
Splice isoforms : SwissVarQ9UHF0
PhosPhoSitePlusQ9UHF0
Domaine pattern : Prosite (Expaxy)TACHYKININ (PS00267)   
Domains : Interpro (EBI)Neurokinin-B/TAC3    Tachy_Neuro_lke_CS   
Domain families : Pfam (Sanger)Neurokinin_B (PF03823)   
Domain families : Pfam (NCBI)pfam03823   
Conserved Domain (NCBI)TAC3
DMDM Disease mutations6866
Blocks (Seattle)TAC3
PDB (RSDB)1P9F   
PDB Europe1P9F   
PDB (PDBSum)1P9F   
PDB (IMB)1P9F   
Structural Biology KnowledgeBase1P9F   
SCOP (Structural Classification of Proteins)1P9F   
CATH (Classification of proteins structures)1P9F   
SuperfamilyQ9UHF0
Human Protein Atlas [tissue]ENSG00000166863-TAC3 [tissue]
Peptide AtlasQ9UHF0
HPRD08877
IPIIPI00001674   IPI00431183   IPI00554743   IPI00385187   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHF0
IntAct (EBI)Q9UHF0
FunCoupENSG00000166863
BioGRIDTAC3
STRING (EMBL)TAC3
ZODIACTAC3
Ontologies - Pathways
QuickGOQ9UHF0
Ontology : AmiGOsignaling receptor binding  extracellular region  extracellular space  G protein-coupled receptor signaling pathway  tachykinin receptor signaling pathway  neuropeptide signaling pathway  female pregnancy  
Ontology : EGO-EBIsignaling receptor binding  extracellular region  extracellular space  G protein-coupled receptor signaling pathway  tachykinin receptor signaling pathway  neuropeptide signaling pathway  female pregnancy  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkTAC3
Atlas of Cancer Signalling NetworkTAC3
Wikipedia pathwaysTAC3
Orthology - Evolution
OrthoDB6866
GeneTree (enSembl)ENSG00000166863
Phylogenetic Trees/Animal Genes : TreeFamTAC3
HOGENOMQ9UHF0
Homologs : HomoloGeneTAC3
Homology/Alignments : Family Browser (UCSC)TAC3
Gene fusions - Rearrangements
Fusion : QuiverTAC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAC3
dbVarTAC3
ClinVarTAC3
1000_GenomesTAC3 
Exome Variant ServerTAC3
GNOMAD BrowserENSG00000166863
Varsome BrowserTAC3
Genetic variants : HAPMAP6866
Genomic Variants (DGV)TAC3 [DGVbeta]
DECIPHERTAC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAC3 
Mutations
ICGC Data PortalTAC3 
TCGA Data PortalTAC3 
Broad Tumor PortalTAC3
OASIS PortalTAC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTAC3
Mutations and Diseases : HGMDTAC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAC3
DgiDB (Drug Gene Interaction Database)TAC3
DoCM (Curated mutations)TAC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAC3 (select a term)
intoGenTAC3
Cancer3DTAC3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM162330    614839   
Orphanet8668   
DisGeNETTAC3
MedgenTAC3
Genetic Testing Registry TAC3
NextProtQ9UHF0 [Medical]
TSGene6866
GENETestsTAC3
Target ValidationTAC3
Huge Navigator TAC3 [HugePedia]
snp3D : Map Gene to Disease6866
BioCentury BCIQTAC3
ClinGenTAC3
Clinical trials, drugs, therapy
Protein Interactions : CTD6866
Pharm GKB GenePA36298
Clinical trialTAC3
Miscellaneous
canSAR (ICR)TAC3 (select the gene name)
HarmonizomeTAC3
DataMed IndexTAC3
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAC3
EVEXTAC3
GoPubMedTAC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:31:52 CEST 2020

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