TAC3 (tachykinin precursor 3)

2014-11-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
HH10,LncZBTB39,NK3,NKB,NKNB,PRO1155,ZNEUROK1

Other Information

Locus ID:

NCBI: 6866
MIM: 162330
HGNC: 11521
Ensembl: ENSG00000166863

Variants:

dbSNP: 6866
ClinVar: 6866
TCGA: ENSG00000166863
COSMIC: TAC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166863ENST00000300108Q9UHF0
ENSG00000166863ENST00000300108A0A024RB47
ENSG00000166863ENST00000357616Q9UHF0
ENSG00000166863ENST00000357616A0A024RB36
ENSG00000166863ENST00000379411Q9UHF0
ENSG00000166863ENST00000379411A0A024RB97
ENSG00000166863ENST00000393867Q9UHF0
ENSG00000166863ENST00000393867A0A024RB36
ENSG00000166863ENST00000415231Q9UHF0
ENSG00000166863ENST00000415231A0A024RB47
ENSG00000166863ENST00000423597Q9UHF0
ENSG00000166863ENST00000423597A0A024RB97
ENSG00000166863ENST00000438756Q9UHF0
ENSG00000166863ENST00000438756A0A024RB36
ENSG00000166863ENST00000441881Q9UHF0
ENSG00000166863ENST00000441881A0A024RB97
ENSG00000166863ENST00000458521Q9UHF0
ENSG00000166863ENST00000458521A0A024RB47
ENSG00000166863ENST00000615887Q9UHF0
ENSG00000166863ENST00000615887A0A024RB47

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Tachykinin receptors bind tachykininsREACTOMER-HSA-380095
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190790662009TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.242
203322482010TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood.84
186142562009Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback.74
205291192010The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons.65
208005822010Neurokinin B and the hypothalamic regulation of reproduction.63
201947062010TAC3 and TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans.61
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
220318172011Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations.29
229036102012Low degree of overlap between kisspeptin, neurokinin B, and dynorphin immunoreactivities in the infundibular nucleus of young male human subjects challenges the KNDy neuron concept.29
235500132013Interactions between kisspeptins and neurokinin B.17

Citation

Dessen P

TAC3 (tachykinin precursor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74455/tac3