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TACC1 (transforming, acidic coiled-coil containing protein 1)

Written2008-12Ivan Still, Melissa R Eslinger, Brenda Lauffart
Department of Biological Sciences, Arkansas Tech University, 1701 N Boulder Ave Russellville, AR 72801, USA (IS); Department of Chemistry, Life Science Bartlett Hall, United States Military Academy, West Point, New York 10996, USA (MRE); Department of Physical Sciences Arkansas Tech University, 1701 N Boulder Ave Russellville, AR 72801, USA (BL)

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Alias (NCBI)Ga55
HGNC Previous nametransforming, acidic coiled-coil containing protein 1
LocusID (NCBI) 6867
Atlas_Id 42456
Location 8p11.22  [Link to chromosome band 8p11]
Location_base_pair Starts at 38787236 and ends at 38853028 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TACC1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAM9 (8p11.22)::TACC1 (8p11.22)CHD7 (8q12.2)::TACC1 (8p11.22)FGFR1 (8p11.23)::TACC1 (8p11.22)
GEMIN5 (5q33.2)::TACC1 (8p11.22)HLA-B (6p21.33)::TACC1 (8p11.22)SCOC (4q31.1)::TACC1 (8p11.22)
SHANK2 (11q13.3)::TACC1 (8p11.22)SMAD3 (15q22.33)::TACC1 (8p11.22)TACC1 (8p11.22)::PLXNB2 (22q13.33)
TACC1 (8p11.22)::TACC1 (8p11.22)
Note This gene has three proposed transcription start sites beginning at 38763938bp, 38733914bp, 38705165bp from pter.


  Transcripts depicted above encompass most transcripts evident in ACEVIEW and USGC genome browsers. Most other ACEVIEW "transcripts" appear to be subsets of those shown or unspliced.
Description The gene is composed of 19 exons spanning 124.5kb.
Transcription Encodes 11 confirmed splice variants in humans (Line et al., 2002; Lauffart et al., 2006). TACC1A 7735nt, TACC1A* 7521nt, TACC1B 6204nt, TACC1C 6194nt, TACC1D 6193nt,TACC1E 7345nt, TACC1F 7770nt, TACC1G 7904nt (utilizes internal splice site in exon 5), TACC1H 7319nt, TACC1I 7424nt, TACC1S 6528nt. Fully sequenced singleton cDNAs e.g. AK304507 and AK303596 suggest additional variants possible. AK304507 utilizes internal splice site in exon 5. Inclusion of alternate 5' noncoding exons indicated from expressed sequence tags identified in a global search for alternative promoters e.g. DA066351, DA950013 (Kimura et al., 2006).
  • AK304507 and AK303596 sequences may be suspect (see UCSC Genome Bioinformatics Site ( for more details.
  • Transcript/isoform nomenclature as per Line et al, 2002 and Lauffart et al., 2006. TACC1F transcript includes exon 1, 2 and 3 (correction to Fig 6 of Lauffart et al., 2006).
  • Pseudogene Partially processed pseudogene:

  • 91% identity corresponding to base 596 to 2157 of AF049910.
    • Location: 10p11.21.
    • Location base pair: Starts at 37851943 and ends at 37873633 from pter (according to hg18-March_2006).
  • 87% identity corresponding to base 7381 to 7742 of AF049910.
    • Location: 8p21.
    • Location base pair: Starts at 84786555 and ends at 84786906 from pter (according to hg18-March_2006).
  • Protein

    Note 11 confirmed splice variants generate 9 different protein isoforms. Two additional isoforms suggested by AK304507 and AK303596.
    Inclusion of alternative promoters and 5' non coding exons produce one of these known protein isofroms e.g. transcripts defined by DA950013, or BQ888599 would produce TACC1E/H, transcripts defined by DA066351 would produce TACC1A/A* and transcripts defined by DC325260 would produce TACC1B.
      Protein Isoforms
    Description TACC1A/TACC1A*, 805 amino acids, 87.8kDa, TACC1B 243 amino acids 19.4kDa, TACC1C 367 amino acids 40.9kDa, TACC1D 379 amino acids 42.3kDa, TACC1E/H 610 amino acids 67.1kDa, TACC1F 817 amino acids 89kDa, TACC1G 731 amino acids 79.9kDa, TACC1I 777 amino acids 84kDa, TACC1S 395 amino acids 44kDa, BAG65314 792 amino acids 86.2kDa, BAG64611 476 amino acids 51.5kDa.
    Expression Wide expression in fetus and adult. Detailed analysis reported during mouse development by Lauffart et al., 2006.
    Localisation TACC1 is located in the nucleus and/or cytosol, depending on isoform and cell type (Lauffart et al., 2006). Exon 3 contains a predicted nuclear localisation signal. Most immunohistochemical analyses in sectioned tissues have used antibodies that recognize an epitope located in Exon 3. Thus, studies at the protein level have concentrated on exon 3 containing isoforms A, A*, E, F, G, H and I, but fail to differentiate between them. TACC1A weakly interacts with the centrosome during mitosis (Gergely et al., 2000). Overexpression can result in accumulation in cytoplasm in some cells resulting in oligmerisation in punctate structures (Gergely et al., 2000).
    Function TACC1 has been proposed to function in microtubule dynamics in interphase, mitosis and cytokinesis based upon interactions with Aurora A kinase and Aurora B kinase and CKAP5 (ch-TOG/XMAP215) by interactions with the TACC domain (see Pessat and Vernos 2008 for Review). TACC1A may function in RNA splicing, decapping and/or degradation through interactions with SmG (SNRPG) and LSm-7 (LSM7) via amino acids 1-53 (Conte et al., 2002). Increased expression of TACC1A in mammary gland activates ras-MAPK and PI-3K pathways (Cully et al., 2005). The former may be due in part on TACC1A-mediated retention of pERK in the cytoplasm (Lauffart et al., 2007b). Nuclear localized TACC1 is phosphorylated on S50,S52,S54,S55,S57, cytoplasmic TACC1 is phosphorylated on S275, while Y533 is phosphorylated in Jurkat cells (Rush et al., 2005, Olsen et al., 2006). Amino acids 152-258 binds to TDRD7, but function of this interaction is unknown (Conte et al., 2003). TACC1A is a possible indirect activator of CREB via FHL family of proteins (Lauffart et al., 2007b). Uncharacterized roles in transcriptional regulation have been proposed based on TACC1 binding to GAS41 (YEATS4) via amino acid 206-427, hGCN5L2 (KAT2A), FHL coactivator/corepressor proteins and retinoid X-receptor beta via the TACC domain (Gangisetty, 2004; Lauffart et al., 2002; 2007b; 2008; Vettaikkorumakankauv et al., 2008). TACC1A can interact with BARD1 in vitro, and is phosphorylated on serine residue 44 in response to DNA damage (Matsuoka et al., 2007).
    Amino acid residues involved in binding or subject to phosphorylation are quoted for TACC1A, but residues, if present in other isoforms, may also be subject to the same interactions or modifications.
    Homology Founding member of the TACC family, based on the presence of the conserved approximately 200 amino acid carboxy terminal coiled coil domain (TACC domain) (Still et al., 1999; Still et al., 2004).


    Note To date, no mutation of TACC1 gene have been described.

    Implicated in

    Entity Breast cancer
    Prognosis Expression associated with resistance to tamoxifen and fulvestrant and shorter relapse-free survival (Ghayad et al., 2008).
    Oncogenesis TACC1 protein downregulated in breast cancer (Conte et al., 2002). Expression retained in tamoxifen and fulvestrant resistant tumors (Ghayad et al., 2008).
    Entity Ovarian Cancer
    Prognosis Retention of expression in Stage III tumors associated with favorable prognosis (Partheen et al., 2006).
    Oncogenesis Total cellular expression or nuclear localization lost in ovarian cancer (Lauffart et al., 2005).
    Entity Wilms' Tumor
    Prognosis Expression associated with more favorable prognosis (Li et al., 2005)
    Oncogenesis Expressed at lower levels in anaplastic versus tumors with favorable histology (Li et al., 2005).
    Entity Gastric Cancer
    Prognosis Increased expression of TACC1D and TACC1F variants associated with gastric cancer (Line et al., 2002).
    Oncogenesis Change in splicing pattern in gastric cancer (Line et al., 2002).
    Entity Prostate Cancer
    Prognosis Increased expression of TACC1 detected in advanced stages (pT3 and/or N1/M1) and associated with androgen-independent prostate carcinoma (Devilard et al., 2006).
    Oncogenesis TACC1 protein expression in prostate cancer noted in cytoplasm (Devilard et al., 2006), compared to nucleus in normal prostate epithelium (Lauffart et al., 2006).


    Note Potential deletion as a result of translocation event associated with 8p11 myeloproliferative disorder (Etienne et al., 2007).

    To be noted

    The gene name TACC1, for Transforming Acidic Coiled coil containing was derived based on the initial finding that this gene could transform murine fibroblasts and is found in a chromosomal region amplified in breast cancer (Still et al., 1999). Studies in transgenic mice have demonstrated that constitutive overexpression of the TACC1A variant in the mammary gland predisposes to the development of breast cancer (Cully et al., 2005). This may be mediated by the aberrant activation of the ras-MAPK and PI-3K pathways. The former may be due in part to TACC1A mediated retention of pERK in the cytoplasm (Lauffart et al., 2007b). However, other studies have suggested that TACC1 protein is lost or mislocalised in breast cancer (Conte et al., 2002) and ovarian cancer (Lauffart et al., 2005).

    The molecular function of this protein is still unclear. The protein is implicated in centrosomal dynamics during mitosis through confirmed interactions with ch-TOG/XMAP215 and Aurora kinase family members (Peset and Vernos, 2008 for review). TACC1 is also implicated in cytokinesis (Delaval et al., 2004). siRNA knockdown results in multipolar spindles but fails to impede the cell cycle (Gergely et al., 2003). TACC1A is involved in intracellular signaling pathways as a substrate (Rush et al., 2005; Olsen et al., 2006), and can interfere with ras-MAPK and PI-3K pathways (Cully et al., 2005; Lauffart et al., 2007b). TACC1A is highly phosphorylated cells (S50,S52,S54,S55,S57,S275, Y533 of TACC1A) (Rush et al., 2005; Olsen et al., 2006), in part accounting for aberrant migration of protein in SDS-polyacrylamide gel electrophoresis (Lauffart et al., 2002). TACC1A is phosphorylated in response to DNA damage on S44 (Matsuoka et al., 2007). Role in DNA damage response is unknown, although TACC3 has been shown to have some protective affects against adriamycin mediated DNA damage in ovarian cancer cells (Lauffart et al., 2007a). Alternative functions have been ascribed in transcription through interaction with FHL proteins (Lauffart et al., 2007b), YEATS4 (GAS41) and the (SWI/SNF) chromatin remodeling complex (Lauffart et al., 2002), KAT2A (hGCN5L2) (Gangisetty et al., 2004), retinoid-X receptor (Vettaikkorumakankauv et al., 2008) and RNA processing through SmG and LSm-7 (Conte et al., 2002).


    Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators.
    Conte N, Charafe-Jauffret E, Delaval B, Adelaide J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D.
    Oncogene. 2002 Aug 15;21(36):5619-30.
    PMID 12165861
    TACC1-chTOG-Aurora A protein complex in breast cancer.
    Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Seraphin B, Jacquemier J, Birnbaum D.
    Oncogene. 2003 Nov 6;22(50):8102-16.
    PMID 14603251
    Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis.
    Cully M, Shiu J, Piekorz RP, Muller WJ, Done SJ, Mak TW.
    Cancer Res. 2005 Nov 15;65(22):10363-70.
    PMID 16288026
    Aurora B -TACC1 protein complex in cytokinesis.
    Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D.
    Oncogene. 2004 Jun 3;23(26):4516-22.
    PMID 15064709
    FGFR1 and WT1 are markers of human prostate cancer progression.
    Devilard E, Bladou F, Ramuz O, Karsenty G, Dales JP, Gravis G, Nguyen C, Bertucci F, Xerri L, Birnbaum D.
    BMC Cancer. 2006 Nov 30;6:272.
    PMID 17137506
    Combined translocation with ZNF198-FGFR1 gene fusion and deletion of potential tumor suppressors in a myeloproliferative disorder.
    Etienne A, Gelsi-Boyer V, Carbuccia N, Adelaide J, Barba G, La Starza R, Murati A, Eclache V, Birg F, Birnbaum D, Mozziconacci MJ, Mecucci C, Chaffanet M.
    Cancer Genet Cytogenet. 2007 Mar;173(2):154-8.
    PMID 17321332
    The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases.
    Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH.
    Oncogene. 2004 Apr 1;23(14):2559-63.
    PMID 14767476
    The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells.
    Gergely F, Draviam VM, Raff JW.
    Genes Dev. 2003 Feb 1;17(3):336-41.
    PMID 12569123
    The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.
    Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW.
    Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14352-7.
    PMID 11121038
    Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer.
    Ghayad SE, Vendrell JA, Bieche I, Spyratos F, Dumontet C, Treilleux I, Lidereau R, Cohen PA.
    J Mol Endocrinol. 2009 Feb;42(2):87-103. Epub 2008 Nov 4.
    PMID 18984771
    Diversification of Transcriptional Modulation: Large-scale Identification and Characterization of Putative Alternative Promoters of Human Genes.
    Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S.
    Genome Res. 2006 Jan;16(1):55-65. Epub 2005 Dec 12.
    PMID 16344560
    Interaction of TACC proteins with the FHL family: implications for ERK signaling.
    Lauffart B, Sondarva GV, Gangisetty O, Cincotta M, Still IH.
    J Cell Commun Signal. 2007b Jun;1(1):5-15. Epub 2007 Mar 28.
    PMID 18481206
    Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia.
    Li W, Kessler P, Williams BR.
    Oncogene. 2005 Jan 13;24(3):457-68.
    PMID 15531917
    Altered splicing pattern of TACC1 mRNA in gastric cancer.
    Line A, Slucka Z, Stengrevics A, Li G, Rees RC.
    Cancer Genet Cytogenet. 2002 Nov;139(1):78-83.
    PMID 12547166
    ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
    Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ.
    Science. 2007 May 25;316(5828):1160-6.
    PMID 17525332
    Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
    Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M.
    Cell. 2006 Nov 3;127(3):635-48.
    PMID 17081983
    Expression analysis of stage III serous ovarian adenocarcinoma distinguishes a sub-group of survivors.
    Partheen K, Levan K, Osterberg L, Horvath G.
    Eur J Cancer. 2006 Nov;42(16):2846-54. Epub 2006 Sep 22.
    PMID 16996261
    The TACC proteins: TACC-ling microtubule dynamics and centrosome function.
    Peset I, Vernos I.
    Trends Cell Biol. 2008 Aug;18(8):379-88. Epub 2008 Jul 23.
    PMID 18656360
    Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
    Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ.
    Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12.
    PMID 15592455
    Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon.
    Still IH, Hamilton M, Vince P, Wolfman A, Cowell JK.
    Oncogene. 1999 Jul 8;18(27):4032-8.
    PMID 10435627
    Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms.
    Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P.
    BMC Evol Biol. 2004 Jun 18;4:16.
    PMID 15207008
    The TACC proteins are coregulators of the Retinoid X Receptor beta.
    Vettaikkorumakankauv AK, Lauffart B, Gangisetty O, Cincotta MA, Hawthorne LA, Cowell JK, Still IH.
    Cancer Therapy. 2008 Dec; 6 (2): 805-816.


    This paper should be referenced as such :
    Still, I ; Eslinger, MR ; Lauffart, B
    TACC1 (transforming, acidic coiled-coil containing protein 1)
    Atlas Genet Cytogenet Oncol Haematol. 2009;13(11):875-879.
    Free journal version : [ pdf ]   [ DOI ]

    External links

    HGNC (Hugo)TACC1   11522
    Atlas Explorer : (Salamanque)TACC1
    Entrez_Gene (NCBI)TACC1    transforming acidic coiled-coil containing protein 1
    GeneCards (Weizmann)TACC1
    Ensembl hg19 (Hinxton)ENSG00000147526 [Gene_View]
    Ensembl hg38 (Hinxton)ENSG00000147526 [Gene_View]  ENSG00000147526 [Sequence]  chr8:38787236-38853028 [Contig_View]  TACC1 [Vega]
    ICGC DataPortalENSG00000147526
    TCGA cBioPortalTACC1
    AceView (NCBI)TACC1
    Genatlas (Paris)TACC1
    SOURCE (Princeton)TACC1
    Genetics Home Reference (NIH)TACC1
    Genomic and cartography
    GoldenPath hg38 (UCSC)TACC1  -     chr8:38787236-38853028 +  8p11.22   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)TACC1  -     8p11.22   [Description]    (hg19-Feb_2009)
    GoldenPathTACC1 - 8p11.22 [CytoView hg19]  TACC1 - 8p11.22 [CytoView hg38]
    Genome Data Viewer NCBITACC1 [Mapview hg19]  
    Gene and transcription
    Genbank (Entrez)AB029026 AF049910 AF075051 AI129797 AK057659
    RefSeq transcript (Entrez)NM_001122824 NM_001146216 NM_001330521 NM_001352778 NM_001352779 NM_001352780 NM_001352781 NM_001352782 NM_001352783 NM_001352784 NM_001352785 NM_001352786 NM_001352787 NM_001352788 NM_001352789 NM_001352790 NM_001352791 NM_001352792 NM_001352793 NM_001352794 NM_001352795 NM_001352796 NM_001352797 NM_001352798 NM_001352799 NM_001352800 NM_001352801 NM_001352802 NM_001352803 NM_001352804 NM_006283
    Consensus coding sequences : CCDS (NCBI)TACC1
    Gene ExpressionTACC1 [ NCBI-GEO ]   TACC1 [ EBI - ARRAY_EXPRESS ]   TACC1 [ SEEK ]   TACC1 [ MEM ]
    Gene Expression Viewer (FireBrowse)TACC1 [ Firebrowse - Broad ]
    GenevisibleExpression of TACC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)6867
    GTEX Portal (Tissue expression)TACC1
    Human Protein AtlasENSG00000147526-TACC1 [pathology]   [cell]   [tissue]
    Protein : pattern, domain, 3D structure
    Domain families : Pfam (Sanger)
    Domain families : Pfam (NCBI)
    Conserved Domain (NCBI)TACC1
    Human Protein Atlas [tissue]ENSG00000147526-TACC1 [tissue]
    Protein Interaction databases
    Ontologies - Pathways
    PubMed66 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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