Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TACR1 (tachykinin receptor 1)

Identity

Alias_namesTAC1R
Alias_symbol (synonym)SPR
NK1R
NKIR
Other alias
HGNC (Hugo) TACR1
LocusID (NCBI) 6869
Atlas_Id 47535
Location 2p12  [Link to chromosome band 2p12]
Location_base_pair Starts at 75051036 and ends at 75199519 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRIM1 (2p22.3) / TACR1 (2p12)TACR1 (2p12) / TACR1 (2p12)CRIM1 2p22.3 / TACR1 2p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(p12;p22) CRIM1/TACR1


External links

Nomenclature
HGNC (Hugo)TACR1   11526
Cards
Entrez_Gene (NCBI)TACR1  6869  tachykinin receptor 1
AliasesNK1R; NKIR; SPR; TAC1R
GeneCards (Weizmann)TACR1
Ensembl hg19 (Hinxton)ENSG00000115353 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115353 [Gene_View]  ENSG00000115353 [Sequence]  chr2:75051036-75199519 [Contig_View]  TACR1 [Vega]
ICGC DataPortalENSG00000115353
TCGA cBioPortalTACR1
AceView (NCBI)TACR1
Genatlas (Paris)TACR1
WikiGenes6869
SOURCE (Princeton)TACR1
Genetics Home Reference (NIH)TACR1
Genomic and cartography
GoldenPath hg38 (UCSC)TACR1  -     chr2:75051036-75199519 -  2p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TACR1  -     2p12   [Description]    (hg19-Feb_2009)
EnsemblTACR1 - 2p12 [CytoView hg19]  TACR1 - 2p12 [CytoView hg38]
Mapping of homologs : NCBITACR1 [Mapview hg19]  TACR1 [Mapview hg38]
OMIM162323   
Gene and transcription
Genbank (Entrez)AK289765 AW206679 AY462098 BC074911 BC074912
RefSeq transcript (Entrez)NM_001058 NM_015727
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TACR1
Cluster EST : UnigeneHs.633301 [ NCBI ]
CGAP (NCI)Hs.633301
Alternative Splicing GalleryENSG00000115353
Gene ExpressionTACR1 [ NCBI-GEO ]   TACR1 [ EBI - ARRAY_EXPRESS ]   TACR1 [ SEEK ]   TACR1 [ MEM ]
Gene Expression Viewer (FireBrowse)TACR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6869
GTEX Portal (Tissue expression)TACR1
Human Protein AtlasENSG00000115353-TACR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25103   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25103  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25103
Splice isoforms : SwissVarP25103
PhosPhoSitePlusP25103
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Neurokn_rcpt    NK1_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)TACR1
DMDM Disease mutations6869
Blocks (Seattle)TACR1
PDB (SRS)2KS9    2KSA    2KSB   
PDB (PDBSum)2KS9    2KSA    2KSB   
PDB (IMB)2KS9    2KSA    2KSB   
PDB (RSDB)2KS9    2KSA    2KSB   
Structural Biology KnowledgeBase2KS9    2KSA    2KSB   
SCOP (Structural Classification of Proteins)2KS9    2KSA    2KSB   
CATH (Classification of proteins structures)2KS9    2KSA    2KSB   
SuperfamilyP25103
Human Protein Atlas [tissue]ENSG00000115353-TACR1 [tissue]
Peptide AtlasP25103
HPRD01208
IPIIPI00012729   IPI00220633   
Protein Interaction databases
DIP (DOE-UCLA)P25103
IntAct (EBI)P25103
FunCoupENSG00000115353
BioGRIDTACR1
STRING (EMBL)TACR1
ZODIACTACR1
Ontologies - Pathways
QuickGOP25103
Ontology : AmiGOtachykinin receptor activity  protein binding  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  inflammatory response  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  tachykinin receptor signaling pathway  tachykinin receptor signaling pathway  detection of abiotic stimulus  substance P receptor activity  substance P receptor activity  sperm flagellum  response to pain  sperm head  regulation of uterine smooth muscle contraction  sperm midpiece  sperm midpiece  positive regulation of flagellated sperm motility  positive regulation of flagellated sperm motility  
Ontology : EGO-EBItachykinin receptor activity  protein binding  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  inflammatory response  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  tachykinin receptor signaling pathway  tachykinin receptor signaling pathway  detection of abiotic stimulus  substance P receptor activity  substance P receptor activity  sperm flagellum  response to pain  sperm head  regulation of uterine smooth muscle contraction  sperm midpiece  sperm midpiece  positive regulation of flagellated sperm motility  positive regulation of flagellated sperm motility  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Measles   
NDEx NetworkTACR1
Atlas of Cancer Signalling NetworkTACR1
Wikipedia pathwaysTACR1
Orthology - Evolution
OrthoDB6869
GeneTree (enSembl)ENSG00000115353
Phylogenetic Trees/Animal Genes : TreeFamTACR1
HOVERGENP25103
HOGENOMP25103
Homologs : HomoloGeneTACR1
Homology/Alignments : Family Browser (UCSC)TACR1
Gene fusions - Rearrangements
Fusion : MitelmanCRIM1/TACR1 [2p22.3/2p12]  [t(2;2)(p12;p22)]  
Fusion PortalCRIM1 2p22.3 TACR1 2p12 KIRC
Fusion : QuiverTACR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTACR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TACR1
dbVarTACR1
ClinVarTACR1
1000_GenomesTACR1 
Exome Variant ServerTACR1
ExAC (Exome Aggregation Consortium)ENSG00000115353
GNOMAD BrowserENSG00000115353
Varsome BrowserTACR1
Genetic variants : HAPMAP6869
Genomic Variants (DGV)TACR1 [DGVbeta]
DECIPHERTACR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTACR1 
Mutations
ICGC Data PortalTACR1 
TCGA Data PortalTACR1 
Broad Tumor PortalTACR1
OASIS PortalTACR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTACR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTACR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TACR1
DgiDB (Drug Gene Interaction Database)TACR1
DoCM (Curated mutations)TACR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TACR1 (select a term)
intoGenTACR1
Cancer3DTACR1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM162323   
Orphanet
DisGeNETTACR1
MedgenTACR1
Genetic Testing Registry TACR1
NextProtP25103 [Medical]
TSGene6869
GENETestsTACR1
Target ValidationTACR1
Huge Navigator TACR1 [HugePedia]
snp3D : Map Gene to Disease6869
BioCentury BCIQTACR1
ClinGenTACR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6869
Chemical/Pharm GKB GenePA36302
Clinical trialTACR1
Miscellaneous
canSAR (ICR)TACR1 (select the gene name)
Probes
Litterature
PubMed182 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTACR1
EVEXTACR1
GoPubMedTACR1
iHOPTACR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:43:28 CET 2018

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