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TACR2 (tachykinin receptor 2)

Identity

Alias_namesTAC2R
NKNAR
Alias_symbol (synonym)SKR
NK2R
Other alias
HGNC (Hugo) TACR2
LocusID (NCBI) 6865
Atlas_Id 53237
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 69404202 and ends at 69416918 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TACR2   11527
Cards
Entrez_Gene (NCBI)TACR2  6865  tachykinin receptor 2
AliasesNK2R; NKNAR; SKR; TAC2R
GeneCards (Weizmann)TACR2
Ensembl hg19 (Hinxton)ENSG00000075073 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075073 [Gene_View]  chr10:69404202-69416918 [Contig_View]  TACR2 [Vega]
ICGC DataPortalENSG00000075073
TCGA cBioPortalTACR2
AceView (NCBI)TACR2
Genatlas (Paris)TACR2
WikiGenes6865
SOURCE (Princeton)TACR2
Genetics Home Reference (NIH)TACR2
Genomic and cartography
GoldenPath hg38 (UCSC)TACR2  -     chr10:69404202-69416918 -  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TACR2  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblTACR2 - 10q22.1 [CytoView hg19]  TACR2 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBITACR2 [Mapview hg19]  TACR2 [Mapview hg38]
OMIM162321   
Gene and transcription
Genbank (Entrez)AK096906 AK291996 AK300649 AY322545 BC033742
RefSeq transcript (Entrez)NM_001057
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TACR2
Cluster EST : UnigeneHs.88372 [ NCBI ]
CGAP (NCI)Hs.88372
Alternative Splicing GalleryENSG00000075073
Gene ExpressionTACR2 [ NCBI-GEO ]   TACR2 [ EBI - ARRAY_EXPRESS ]   TACR2 [ SEEK ]   TACR2 [ MEM ]
Gene Expression Viewer (FireBrowse)TACR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6865
GTEX Portal (Tissue expression)TACR2
Human Protein AtlasENSG00000075073-TACR2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21452   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21452  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21452
Splice isoforms : SwissVarP21452
PhosPhoSitePlusP21452
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    Neurokn_rcpt    NK2_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)TACR2
DMDM Disease mutations6865
Blocks (Seattle)TACR2
SuperfamilyP21452
Human Protein Atlas [tissue]ENSG00000075073-TACR2 [tissue]
Peptide AtlasP21452
HPRD01207
IPIIPI00412405   IPI00641348   IPI00979309   
Protein Interaction databases
DIP (DOE-UCLA)P21452
IntAct (EBI)P21452
FunCoupENSG00000075073
BioGRIDTACR2
STRING (EMBL)TACR2
ZODIACTACR2
Ontologies - Pathways
QuickGOP21452
Ontology : AmiGOtachykinin receptor activity  protein binding  plasma membrane  integral component of plasma membrane  muscle contraction  tachykinin receptor signaling pathway  chemical synaptic transmission  excretion  positive regulation of acetylcholine secretion, neurotransmission  intestine smooth muscle contraction  substance K receptor activity  negative regulation of luteinizing hormone secretion  operant conditioning  positive regulation of vascular permeability  positive regulation of smooth muscle contraction  response to electrical stimulus  prolactin secretion  positive regulation of uterine smooth muscle contraction  
Ontology : EGO-EBItachykinin receptor activity  protein binding  plasma membrane  integral component of plasma membrane  muscle contraction  tachykinin receptor signaling pathway  chemical synaptic transmission  excretion  positive regulation of acetylcholine secretion, neurotransmission  intestine smooth muscle contraction  substance K receptor activity  negative regulation of luteinizing hormone secretion  operant conditioning  positive regulation of vascular permeability  positive regulation of smooth muscle contraction  response to electrical stimulus  prolactin secretion  positive regulation of uterine smooth muscle contraction  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkTACR2
Atlas of Cancer Signalling NetworkTACR2
Wikipedia pathwaysTACR2
Orthology - Evolution
OrthoDB6865
GeneTree (enSembl)ENSG00000075073
Phylogenetic Trees/Animal Genes : TreeFamTACR2
HOVERGENP21452
HOGENOMP21452
Homologs : HomoloGeneTACR2
Homology/Alignments : Family Browser (UCSC)TACR2
Gene fusions - Rearrangements
Fusion: Tumor Portal TACR2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTACR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TACR2
dbVarTACR2
ClinVarTACR2
1000_GenomesTACR2 
Exome Variant ServerTACR2
ExAC (Exome Aggregation Consortium)ENSG00000075073
GNOMAD BrowserENSG00000075073
Genetic variants : HAPMAP6865
Genomic Variants (DGV)TACR2 [DGVbeta]
DECIPHERTACR2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTACR2 
Mutations
ICGC Data PortalTACR2 
TCGA Data PortalTACR2 
Broad Tumor PortalTACR2
OASIS PortalTACR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTACR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTACR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TACR2
DgiDB (Drug Gene Interaction Database)TACR2
DoCM (Curated mutations)TACR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TACR2 (select a term)
intoGenTACR2
Cancer3DTACR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM162321   
Orphanet
MedgenTACR2
Genetic Testing Registry TACR2
NextProtP21452 [Medical]
TSGene6865
GENETestsTACR2
Target ValidationTACR2
Huge Navigator TACR2 [HugePedia]
snp3D : Map Gene to Disease6865
BioCentury BCIQTACR2
ClinGenTACR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6865
Chemical/Pharm GKB GenePA36303
Clinical trialTACR2
Miscellaneous
canSAR (ICR)TACR2 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTACR2
EVEXTACR2
GoPubMedTACR2
iHOPTACR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:13:38 CET 2017

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