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TAF15 (TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)

Written2000-09Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)TAFIIN
TAF2N (TATA box binding protein (TBP)-associated factor, RNA polymerase II, N)
RBP56 (RNA binding protein 56)
TAFII68
HGNC (Hugo) TAF15
HGNC Alias symbhTAFII68
RBP56
Npl3
HGNC Previous nameTAF2N
HGNC Previous nameTATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)
 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
LocusID (NCBI) 8148
Atlas_Id 256
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 35809484 and ends at 35847242 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TAF15.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHN1 (2q31.1)::TAF15 (17q12)NR4A3 (9q22.33)::TAF15 (17q12)NR4A3 (9q31.1)::TAF15 (17q12)
OSCP1 (1p34.3)::TAF15 (17q12)PLA2G2A (1p36.13)::TAF15 (17q12)ST8SIA6 (10p12.33)::TAF15 (17q12)
TAF15 (17q12)::ADGRL1 (19p13.12)TAF15 (17q12)::AP2B1 (17q12)TAF15 (17q12)::CHN1 (2q31.1)
TAF15 (17q12)::CNBP (3q21.3)TAF15 (17q12)::DCAF8 (1q23.2)TAF15 (17q12)::MAN1A2 (1p12)
TAF15 (17q12)::NR4A3 (9q22.33)TAF15 (17q12)::NR4A3 (9q31.1)TAF15 (17q12)::OSCP1 (1p34.3)
TAF15 (17q12)::PARM1 (4q13.3)TAF15 (17q12)::ZNF384 (12p13.31)ZNF384 (12p13.31)::TAF15 (17q12)

DNA/RNA

Description spans 37kb; 16 exons
Transcription 2.2 bp mRNA; alternative splicing: two isoforms of cDNAs consisting of 2144 and 2153 bp; coding sequence 1778 bp

Protein

Description 589 and 592 amino acid, 62 kDa ; comprises a N-term ser, tyr, gln, gly -rich region, followed by a an RNA binding domain and a Cys2/Cys2 finger motif, and repeats in C-term
Expression wide; in the fetus and in the adult
Localisation nuclear
Function single strand DNA/RNA binding protein; part of theTFIID and RNA polymerase II complex of proteins which assemble on the promoter to form a pre-initiation complex (PIC); TFIID is composed of a TATA-box-binding protein (TBP) and a number of TBP-associated factors (TAFIIS); contribute to the activation of transcription
Homology with EWSR1 and FUS

Mutations

Somatic overexpression of TAF2N- FLI-1 chimeras in NIH3T3 cells leads to oncogenic transformation

Implicated in

Note
  
Entity --> 5 prime TAF15 3 prime TEC
Disease a rare tumour: 2.3% of soft tissue sarcomas often localized in deep soft tissues of the lower extremities
  

Breakpoints

 

Bibliography

The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties.
Bertolotti A, Bell B, Tora L
Oncogene. 1999 ; 18 (56) : 8000-8010.
PMID 10637511
 
TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes.
Green MR
Trends in biochemical sciences. 2000 ; 25 (2) : 59-63.
PMID 10664584
 
Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M
Gene. 1998 ; 221 (2) : 191-198.
PMID 9795213
 
Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11).
Panagopoulos I, Mencinger M, Dietrich CU, Bjerkehagen B, Saeter G, Mertens F, Mandahl N, Heim S
Oncogene. 1999 ; 18 (52) : 7594-7598.
PMID 10602519
 
Yeast TAFIIS in a multisubunit complex required for activated transcription.
Reese JC, Apone L, Walker SS, Griffin LA, Green MR
Nature. 1994 ; 371 (6497) : 523-527.
PMID 7935765
 
Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
Sjögren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G
Cancer research. 1999 ; 59 (20) : 5064-5067.
PMID 10537274
 

Citation

This paper should be referenced as such :
Huret, JL
TAF15 (TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):190-191.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;17)(p13;q11) TAF15::ZNF384


External links

 

Nomenclature
HGNC (Hugo)TAF15   11547
Cards
AtlasTAF2NID256
Entrez_Gene (NCBI)TAF15    TATA-box binding protein associated factor 15
AliasesNpl3; RBP56; TAF2N; TAFII68
GeneCards (Weizmann)TAF15
Ensembl hg19 (Hinxton)ENSG00000270647 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000270647 [Gene_View]  ENSG00000270647 [Sequence]  chr17:35809484-35847242 [Contig_View]  TAF15 [Vega]
ICGC DataPortalENSG00000270647
TCGA cBioPortalTAF15
AceView (NCBI)TAF15
Genatlas (Paris)TAF15
SOURCE (Princeton)TAF15
Genetics Home Reference (NIH)TAF15
Genomic and cartography
GoldenPath hg38 (UCSC)TAF15  -     chr17:35809484-35847242 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAF15  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathTAF15 - 17q12 [CytoView hg19]  TAF15 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000270647
Genome Data Viewer NCBITAF15 [Mapview hg19]  
OMIM601574   612237   
Gene and transcription
Genbank (Entrez)AI351964 AK304520 AK307637 AK313223 AK314194
RefSeq transcript (Entrez)NM_003487 NM_139215
Consensus coding sequences : CCDS (NCBI)TAF15
Gene ExpressionTAF15 [ NCBI-GEO ]   TAF15 [ EBI - ARRAY_EXPRESS ]   TAF15 [ SEEK ]   TAF15 [ MEM ]
Gene Expression Viewer (FireBrowse)TAF15 [ Firebrowse - Broad ]
GenevisibleExpression of TAF15 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8148
GTEX Portal (Tissue expression)TAF15
Human Protein AtlasENSG00000270647-TAF15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92804   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92804  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92804
PhosPhoSitePlusQ92804
Domaine pattern : Prosite (Expaxy)RRM (PS50102)    ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    TAF15    TET_fam    Znf_RanBP2    Znf_RanBP2_sf   
Domain families : Pfam (Sanger)RRM_1 (PF00076)    zf-RanBP (PF00641)   
Domain families : Pfam (NCBI)pfam00076    pfam00641   
Domain families : Smart (EMBL)RRM (SM00360)  ZnF_RBZ (SM00547)  
Conserved Domain (NCBI)TAF15
PDB (RSDB)2MMY   
PDB Europe2MMY   
PDB (PDBSum)2MMY   
PDB (IMB)2MMY   
Structural Biology KnowledgeBase2MMY   
SCOP (Structural Classification of Proteins)2MMY   
CATH (Classification of proteins structures)2MMY   
SuperfamilyQ92804
AlphaFold pdb e-kbQ92804   
Human Protein Atlas [tissue]ENSG00000270647-TAF15 [tissue]
HPRD09031
Protein Interaction databases
DIP (DOE-UCLA)Q92804
IntAct (EBI)Q92804
BioGRIDTAF15
STRING (EMBL)TAF15
ZODIACTAF15
Ontologies - Pathways
QuickGOQ92804
Ontology : AmiGODNA binding  transcription coregulator activity  RNA binding  RNA binding  RNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  positive regulation of transcription, DNA-templated  metal ion binding  mRNA stabilization  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA binding  transcription coregulator activity  RNA binding  RNA binding  RNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  positive regulation of transcription, DNA-templated  metal ion binding  mRNA stabilization  regulation of signal transduction by p53 class mediator  
Pathways : KEGGBasal transcription factors    Transcriptional misregulation in cancer   
REACTOMEQ92804 [protein]
REACTOME PathwaysR-HSA-76042 [pathway]   
NDEx NetworkTAF15
Atlas of Cancer Signalling NetworkTAF15
Wikipedia pathwaysTAF15
Orthology - Evolution
OrthoDB8148
GeneTree (enSembl)ENSG00000270647
Phylogenetic Trees/Animal Genes : TreeFamTAF15
Homologs : HomoloGeneTAF15
Homology/Alignments : Family Browser (UCSC)TAF15
Gene fusions - Rearrangements
Fusion : MitelmanPLA2G2A::TAF15 [1p36.13/17q12]  
Fusion : MitelmanTAF15::ZNF384 [17q12/12p13.31]  
Fusion : COSMICTAF15 [17q12]  -  NR4A3 [9q31.1]  [fusion_589]  [fusion_657]  [fusion_957]  [fusion_958]  [fusion_959]  
Fusion Cancer (Beijing)TAF15 [17q12]  -  CNBP [3q21.3]  [FUSC003802]
Fusion : QuiverTAF15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAF15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAF15
dbVarTAF15
ClinVarTAF15
MonarchTAF15
1000_GenomesTAF15 
Exome Variant ServerTAF15
GNOMAD BrowserENSG00000270647
Varsome BrowserTAF15
ACMGTAF15 variants
VarityQ92804
Genomic Variants (DGV)TAF15 [DGVbeta]
DECIPHERTAF15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAF15 
Mutations
ICGC Data PortalTAF15 
TCGA Data PortalTAF15 
Broad Tumor PortalTAF15
OASIS PortalTAF15 [ Somatic mutations - Copy number]
Cancer Gene: CensusTAF15 
Mutations and Diseases : HGMDTAF15
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTAF15
DgiDB (Drug Gene Interaction Database)TAF15
DoCM (Curated mutations)TAF15
CIViC (Clinical Interpretations of Variants in Cancer)TAF15
OncoKBTAF15
NCG (London)TAF15
Cancer3DTAF15
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601574    612237   
Orphanet18668   
DisGeNETTAF15
MedgenTAF15
Genetic Testing Registry TAF15
NextProtQ92804 [Medical]
GENETestsTAF15
Target ValidationTAF15
Huge Navigator TAF15 [HugePedia]
ClinGenTAF15
Clinical trials, drugs, therapy
MyCancerGenomeTAF15
Protein Interactions : CTDTAF15
Pharm GKB GenePA36322
PharosQ92804
Clinical trialTAF15
Miscellaneous
canSAR (ICR)TAF15
HarmonizomeTAF15
DataMed IndexTAF15
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTAF15
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 8 21:29:04 CEST 2021

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.