TAF4 (TATA-box binding protein associated factor 4)

2014-08-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
TAF(II)130,TAF(II)135,TAF2C,TAF2C1,TAF4A,TAFII-130,TAFII-135,TAFII130,TAFII135
FUSION GENES

Other Information

Locus ID:

NCBI: 6874
MIM: 601796
HGNC: 11537
Ensembl: ENSG00000130699

Variants:

dbSNP: 6874
ClinVar: 6874
TCGA: ENSG00000130699
COSMIC: TAF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130699ENST00000252996O00268
ENSG00000130699ENST00000474089V9GY03
ENSG00000130699ENST00000488539V9GY14

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Basal transcription factorsKEGGko03022
Huntington's diseaseKEGGko05016
Basal transcription factorsKEGGhsa03022
Huntington's diseaseKEGGhsa05016
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription InitiationREACTOMER-HSA-167161
RNA Polymerase II HIV Promoter EscapeREACTOMER-HSA-167162
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningREACTOMER-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter ClearanceREACTOMER-HSA-76042
RNA Polymerase II Transcription InitiationREACTOMER-HSA-75953
RNA Polymerase II Promoter EscapeREACTOMER-HSA-73776
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119885362002Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease.204
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182069712008Structural changes in TAF4b-TFIID correlate with promoter selectivity.36
122373042002Crystal structure of a subcomplex of human transcription factor TFIID formed by TATA binding protein-associated factors hTAF4 (hTAF(II)135) and hTAF12 (hTAF(II)20).29
196357972009TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.16
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
240983482013Alternative splicing targeting the hTAF4-TAFH domain of TAF4 represses proliferation and accelerates chondrogenic differentiation of human mesenchymal stem cells.10
233265742013Role of TAF4 in transcriptional activation by Rta of Epstein-Barr Virus.7
285393592017A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.4
128108842003A role of the TATA box and the general co-activator hTAF(II)130/135 in promoter-specific trans-activation by simian virus 40 small t antigen.3

Citation

Dessen P

TAF4 (TATA-box binding protein associated factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54682/taf4