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TAF4 (TATA-box binding protein associated factor 4)

Identity

Alias_namesTAF4A
TAF2C1
TAF2C
TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
Alias_symbol (synonym)TAFII130
TAFII135
Other alias
HGNC (Hugo) TAF4
LocusID (NCBI) 6874
Atlas_Id 54682
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 60549854 and ends at 60640866 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PLCG1 (20q12) / TAF4 (20q13.33)SS18L1 (20q13.33) / TAF4 (20q13.33)TAF4 (20q13.33) / ALG10B (12q12)
TAF4 (20q13.33) / B4GALT5 (20q13.13)TAF4 (20q13.33) / BRIP1 (17q23.2)TAF4 (20q13.33) / CDH4 (20q13.33)
TAF4 (20q13.33) / FAF1 (1p32.3)TAF4 (20q13.33) / HHLA2 (3q13.13)TAF4 (20q13.33) / LAMA5 (20q13.33)
TAF4 (20q13.33) / LSM14B (20q13.33)TAF4 (20q13.33) / PSMA7 (20q13.33)TAF4 (20q13.33) / TAF4 (20q13.33)
TAF4 (20q13.33) / TCFL5 (20q13.33)TAF4 (20q13.33) / TSHZ2 (20q13.2)VAMP2 (17p13.1) / TAF4 (20q13.33)
PLCG1 20q12 / TAF4 20q13.33TAF4 20q13.33 / B4GALT5 20q13.13TAF4 20q13.33 / CDH4 20q13.33
TAF4 20q13.33 / FAF1 1p32.3TAF4 20q13.33 / LAMA5 20q13.33TAF4 20q13.33 / TCFL5 20q13.33
TAF4 20q13.33 / TSHZ2 20q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TAF4   11537
Cards
Entrez_Gene (NCBI)TAF4  6874  TATA-box binding protein associated factor 4
AliasesTAF2C; TAF2C1; TAF4A; TAFII130; 
TAFII135
GeneCards (Weizmann)TAF4
Ensembl hg19 (Hinxton)ENSG00000130699 [Gene_View]  chr20:60549854-60640866 [Contig_View]  TAF4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000130699 [Gene_View]  chr20:60549854-60640866 [Contig_View]  TAF4 [Vega]
ICGC DataPortalENSG00000130699
TCGA cBioPortalTAF4
AceView (NCBI)TAF4
Genatlas (Paris)TAF4
WikiGenes6874
SOURCE (Princeton)TAF4
Genetics Home Reference (NIH)TAF4
Genomic and cartography
GoldenPath hg19 (UCSC)TAF4  -     chr20:60549854-60640866 -  20q13.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TAF4  -     20q13.33   [Description]    (hg38-Dec_2013)
EnsemblTAF4 - 20q13.33 [CytoView hg19]  TAF4 - 20q13.33 [CytoView hg38]
Mapping of homologs : NCBITAF4 [Mapview hg19]  TAF4 [Mapview hg38]
OMIM601796   
Gene and transcription
Genbank (Entrez)AK097744 AK123937 BC167776 U75308 Y11354
RefSeq transcript (Entrez)NM_003185
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011362 NT_187623 NW_004929418
Consensus coding sequences : CCDS (NCBI)TAF4
Cluster EST : UnigeneHs.18857 [ NCBI ]
CGAP (NCI)Hs.18857
Alternative Splicing GalleryENSG00000130699
Gene ExpressionTAF4 [ NCBI-GEO ]   TAF4 [ EBI - ARRAY_EXPRESS ]   TAF4 [ SEEK ]   TAF4 [ MEM ]
Gene Expression Viewer (FireBrowse)TAF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6874
GTEX Portal (Tissue expression)TAF4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00268   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00268
Splice isoforms : SwissVarO00268
PhosPhoSitePlusO00268
Domaine pattern : Prosite (Expaxy)TAFH (PS51119)   
Domains : Interpro (EBI)Histone-fold    TAF4    TAFH_NHR1   
Domain families : Pfam (Sanger)TAF4 (PF05236)    TAFH (PF07531)   
Domain families : Pfam (NCBI)pfam05236    pfam07531   
Domain families : Smart (EMBL)TAFH (SM00549)  
Conserved Domain (NCBI)TAF4
DMDM Disease mutations6874
Blocks (Seattle)TAF4
PDB (SRS)1H3O    2P6V   
PDB (PDBSum)1H3O    2P6V   
PDB (IMB)1H3O    2P6V   
PDB (RSDB)1H3O    2P6V   
Structural Biology KnowledgeBase1H3O    2P6V   
SCOP (Structural Classification of Proteins)1H3O    2P6V   
CATH (Classification of proteins structures)1H3O    2P6V   
SuperfamilyO00268
Human Protein AtlasENSG00000130699
Peptide AtlasO00268
HPRD11797
IPIIPI00413755   IPI00478296   
Protein Interaction databases
DIP (DOE-UCLA)O00268
IntAct (EBI)O00268
FunCoupENSG00000130699
BioGRIDTAF4
STRING (EMBL)TAF4
ZODIACTAF4
Ontologies - Pathways
QuickGOO00268
Ontology : AmiGOovarian follicle development  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIID complex  cytoplasm  DNA-templated transcription, initiation  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  viral process  transcription factor TFTC complex  positive regulation of transcription, DNA-templated  protein heterodimerization activity  MLL1 complex  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIovarian follicle development  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIID complex  cytoplasm  DNA-templated transcription, initiation  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  viral process  transcription factor TFTC complex  positive regulation of transcription, DNA-templated  protein heterodimerization activity  MLL1 complex  regulation of signal transduction by p53 class mediator  
Pathways : KEGGBasal transcription factors    Huntington's disease    Herpes simplex infection   
NDEx NetworkTAF4
Atlas of Cancer Signalling NetworkTAF4
Wikipedia pathwaysTAF4
Orthology - Evolution
OrthoDB6874
GeneTree (enSembl)ENSG00000130699
Phylogenetic Trees/Animal Genes : TreeFamTAF4
HOVERGENO00268
HOGENOMO00268
Homologs : HomoloGeneTAF4
Homology/Alignments : Family Browser (UCSC)TAF4
Gene fusions - Rearrangements
Fusion : MitelmanPLCG1/TAF4 [20q12/20q13.33]  [t(20;20)(q12;q13)]  
Fusion : MitelmanTAF4/ALG10B [20q13.33/12q12]  [t(12;20)(q12;q13)]  
Fusion : MitelmanTAF4/B4GALT5 [20q13.33/20q13.13]  [t(20;20)(q13;q13)]  
Fusion : MitelmanTAF4/BRIP1 [20q13.33/17q23.2]  [t(17;20)(q23;q13)]  
Fusion : MitelmanTAF4/CDH4 [20q13.33/20q13.33]  [t(20;20)(q13;q13)]  
Fusion : MitelmanTAF4/FAF1 [20q13.33/1p32.3]  [t(1;20)(p32;q13)]  
Fusion : MitelmanTAF4/LAMA5 [20q13.33/20q13.33]  [t(20;20)(q13;q13)]  
Fusion : MitelmanTAF4/TCFL5 [20q13.33/20q13.33]  [t(20;20)(q13;q13)]  
Fusion : MitelmanTAF4/TSHZ2 [20q13.33/20q13.2]  [t(20;20)(q13;q13)]  
Fusion: TCGAPLCG1 20q12 TAF4 20q13.33 BRCA
Fusion: TCGATAF4 20q13.33 B4GALT5 20q13.13 BRCA
Fusion: TCGATAF4 20q13.33 CDH4 20q13.33 BRCA
Fusion: TCGATAF4 20q13.33 FAF1 1p32.3 BRCA
Fusion: TCGATAF4 20q13.33 LAMA5 20q13.33 BLCA
Fusion: TCGATAF4 20q13.33 TCFL5 20q13.33 BRCA
Fusion: TCGATAF4 20q13.33 TSHZ2 20q13.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAF4
dbVarTAF4
ClinVarTAF4
1000_GenomesTAF4 
Exome Variant ServerTAF4
ExAC (Exome Aggregation Consortium)TAF4 (select the gene name)
Genetic variants : HAPMAP6874
Genomic Variants (DGV)TAF4 [DGVbeta]
DECIPHER (Syndromes)20:60549854-60640866  ENSG00000130699
CONAN: Copy Number AnalysisTAF4 
Mutations
ICGC Data PortalTAF4 
TCGA Data PortalTAF4 
Broad Tumor PortalTAF4
OASIS PortalTAF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAF4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAF4
DgiDB (Drug Gene Interaction Database)TAF4
DoCM (Curated mutations)TAF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAF4 (select a term)
intoGenTAF4
Cancer3DTAF4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601796   
Orphanet
MedgenTAF4
Genetic Testing Registry TAF4
NextProtO00268 [Medical]
TSGene6874
GENETestsTAF4
Huge Navigator TAF4 [HugePedia]
snp3D : Map Gene to Disease6874
BioCentury BCIQTAF4
ClinGenTAF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6874
Chemical/Pharm GKB GenePA36312
Clinical trialTAF4
Miscellaneous
canSAR (ICR)TAF4 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAF4
EVEXTAF4
GoPubMedTAF4
iHOPTAF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:21:44 CEST 2017

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