TAF4B (TATA-box binding protein associated factor 4b)

2010-08-01  

Identity

HGNC
LOCATION
18q11.2
LOCUSID
ALIAS
SPGF13,TAF2C2,TAFII105
FUSION GENES

Other Information

Locus ID:

NCBI: 6875
MIM: 601689
HGNC: 11538
Ensembl: ENSG00000141384

Variants:

dbSNP: 6875
ClinVar: 6875
TCGA: ENSG00000141384
COSMIC: TAF4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141384ENST00000269142Q92750
ENSG00000141384ENST00000418698Q92750
ENSG00000141384ENST00000578121J3KTH2

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Basal transcription factorsKEGGko03022
Huntington's diseaseKEGGko05016
Basal transcription factorsKEGGhsa03022
Huntington's diseaseKEGGhsa05016
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription InitiationREACTOMER-HSA-167161
RNA Polymerase II HIV Promoter EscapeREACTOMER-HSA-167162
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningREACTOMER-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter ClearanceREACTOMER-HSA-76042
RNA Polymerase II Transcription InitiationREACTOMER-HSA-75953
RNA Polymerase II Promoter EscapeREACTOMER-HSA-73776
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182069712008Structural changes in TAF4b-TFIID correlate with promoter selectivity.36
156018432005Core promoter binding by histone-like TAF complexes.33
244313302014Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia.24
195089982009Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.23
196357972009TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.16
160889612005Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line.8
203539962010TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties.7
273415082016TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis.7
190207612008Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC.3
303365302018Association Study Between MTRR, TAF4B, PIWIL1 Variants and Non-Obstructive Azoospermia in Northeast Chinese Han Population.2

Citation

Dessen P

TAF4B (TATA-box binding protein associated factor 4b)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51581/taf4b