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TAF4B (TATA-box binding protein associated factor 4b)

Identity

Alias_namesTAF2C2
TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Alias_symbol (synonym)TAFII105
Other aliasSPGF13
HGNC (Hugo) TAF4B
LocusID (NCBI) 6875
Atlas_Id 51581
Location 18q11.2  [Link to chromosome band 18q11]
Location_base_pair Starts at 26226883 and ends at 26391686 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RBBP8 (18q11.2) / TAF4B (18q11.2)RIOK3 (18q11.2) / TAF4B (18q11.2)TAF4B (18q11.2) / CHST9 (18q11.2)
RBBP8 18q11.2 / TAF4B 18q11.2RIOK3 18q11.2 / TAF4B 18q11.2TAF4B 18q11.2 / CHST9 18q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TAF4B   11538
Cards
Entrez_Gene (NCBI)TAF4B  6875  TATA-box binding protein associated factor 4b
AliasesSPGF13; TAF2C2; TAFII105
GeneCards (Weizmann)TAF4B
Ensembl hg19 (Hinxton)ENSG00000141384 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141384 [Gene_View]  chr18:26226883-26391686 [Contig_View]  TAF4B [Vega]
ICGC DataPortalENSG00000141384
TCGA cBioPortalTAF4B
AceView (NCBI)TAF4B
Genatlas (Paris)TAF4B
WikiGenes6875
SOURCE (Princeton)TAF4B
Genetics Home Reference (NIH)TAF4B
Genomic and cartography
GoldenPath hg38 (UCSC)TAF4B  -     chr18:26226883-26391686 +  18q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAF4B  -     18q11.2   [Description]    (hg19-Feb_2009)
EnsemblTAF4B - 18q11.2 [CytoView hg19]  TAF4B - 18q11.2 [CytoView hg38]
Mapping of homologs : NCBITAF4B [Mapview hg19]  TAF4B [Mapview hg38]
OMIM601689   615841   
Gene and transcription
Genbank (Entrez)AB234096 AK302593 AY888048 AY888049 BC016360
RefSeq transcript (Entrez)NM_001293725 NM_005640
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAF4B
Cluster EST : UnigeneHs.369519 [ NCBI ]
CGAP (NCI)Hs.369519
Alternative Splicing GalleryENSG00000141384
Gene ExpressionTAF4B [ NCBI-GEO ]   TAF4B [ EBI - ARRAY_EXPRESS ]   TAF4B [ SEEK ]   TAF4B [ MEM ]
Gene Expression Viewer (FireBrowse)TAF4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6875
GTEX Portal (Tissue expression)TAF4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92750   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92750  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92750
Splice isoforms : SwissVarQ92750
PhosPhoSitePlusQ92750
Domaine pattern : Prosite (Expaxy)TAFH (PS51119)   
Domains : Interpro (EBI)Histone-fold    TAF4    TAFH_NHR1   
Domain families : Pfam (Sanger)TAF4 (PF05236)    TAFH (PF07531)   
Domain families : Pfam (NCBI)pfam05236    pfam07531   
Domain families : Smart (EMBL)TAFH (SM00549)  
Conserved Domain (NCBI)TAF4B
DMDM Disease mutations6875
Blocks (Seattle)TAF4B
SuperfamilyQ92750
Human Protein AtlasENSG00000141384
Peptide AtlasQ92750
IPIIPI01010820   IPI00646423   IPI00847648   
Protein Interaction databases
DIP (DOE-UCLA)Q92750
IntAct (EBI)Q92750
FunCoupENSG00000141384
BioGRIDTAF4B
STRING (EMBL)TAF4B
ZODIACTAF4B
Ontologies - Pathways
QuickGOQ92750
Ontology : AmiGOtranscription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly  fibrillar center  DNA binding  transcription coactivator activity  nucleoplasm  nucleoplasm  transcription factor TFIID complex  cytoplasm  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  spermatogenesis  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  oogenesis  NF-kappaB binding  RNA polymerase II transcriptional preinitiation complex assembly  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBItranscription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly  fibrillar center  DNA binding  transcription coactivator activity  nucleoplasm  nucleoplasm  transcription factor TFIID complex  cytoplasm  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  spermatogenesis  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  oogenesis  NF-kappaB binding  RNA polymerase II transcriptional preinitiation complex assembly  regulation of signal transduction by p53 class mediator  
Pathways : KEGGBasal transcription factors    Huntington's disease    Herpes simplex infection   
NDEx NetworkTAF4B
Atlas of Cancer Signalling NetworkTAF4B
Wikipedia pathwaysTAF4B
Orthology - Evolution
OrthoDB6875
GeneTree (enSembl)ENSG00000141384
Phylogenetic Trees/Animal Genes : TreeFamTAF4B
HOVERGENQ92750
HOGENOMQ92750
Homologs : HomoloGeneTAF4B
Homology/Alignments : Family Browser (UCSC)TAF4B
Gene fusions - Rearrangements
Fusion : MitelmanRBBP8/TAF4B [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion : MitelmanRIOK3/TAF4B [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion : MitelmanTAF4B/CHST9 [18q11.2/18q11.2]  [t(18;18)(q11;q11)]  
Fusion: TCGARBBP8 18q11.2 TAF4B 18q11.2 HNSC
Fusion: TCGARIOK3 18q11.2 TAF4B 18q11.2 HNSC
Fusion: TCGATAF4B 18q11.2 CHST9 18q11.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAF4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAF4B
dbVarTAF4B
ClinVarTAF4B
1000_GenomesTAF4B 
Exome Variant ServerTAF4B
ExAC (Exome Aggregation Consortium)TAF4B (select the gene name)
Genetic variants : HAPMAP6875
Genomic Variants (DGV)TAF4B [DGVbeta]
DECIPHERTAF4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAF4B 
Mutations
ICGC Data PortalTAF4B 
TCGA Data PortalTAF4B 
Broad Tumor PortalTAF4B
OASIS PortalTAF4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAF4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAF4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAF4B
DgiDB (Drug Gene Interaction Database)TAF4B
DoCM (Curated mutations)TAF4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAF4B (select a term)
intoGenTAF4B
Cancer3DTAF4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601689    615841   
Orphanet22774   
MedgenTAF4B
Genetic Testing Registry TAF4B
NextProtQ92750 [Medical]
TSGene6875
GENETestsTAF4B
Target ValidationTAF4B
Huge Navigator TAF4B [HugePedia]
snp3D : Map Gene to Disease6875
BioCentury BCIQTAF4B
ClinGenTAF4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6875
Chemical/Pharm GKB GenePA36313
Clinical trialTAF4B
Miscellaneous
canSAR (ICR)TAF4B (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAF4B
EVEXTAF4B
GoPubMedTAF4B
iHOPTAF4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:09:11 CEST 2017

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