Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TAF6 (TATA-box binding protein associated factor 6)

Identity

Alias_namesTAF2E
TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Alias_symbol (synonym)TAFII70
TAFII80
MGC:8964
TAFII85
Other aliasALYUS
TAF(II)70
TAF(II)80
TAFII-70
TAFII-80
HGNC (Hugo) TAF6
LocusID (NCBI) 6878
Atlas_Id 74472
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100107070 and ends at 100119858 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP4M1 (7q22.1) / TAF6 (7q22.1)TRIM4 (7q22.1) / TAF6 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TAF6   11540
Cards
Entrez_Gene (NCBI)TAF6  6878  TATA-box binding protein associated factor 6
AliasesALYUS; MGC:8964; TAF(II)70; TAF(II)80; 
TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85
GeneCards (Weizmann)TAF6
Ensembl hg19 (Hinxton)ENSG00000106290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106290 [Gene_View]  chr7:100107070-100119858 [Contig_View]  TAF6 [Vega]
ICGC DataPortalENSG00000106290
TCGA cBioPortalTAF6
AceView (NCBI)TAF6
Genatlas (Paris)TAF6
WikiGenes6878
SOURCE (Princeton)TAF6
Genetics Home Reference (NIH)TAF6
Genomic and cartography
GoldenPath hg38 (UCSC)TAF6  -     chr7:100107070-100119858 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAF6  -     7q22.1   [Description]    (hg19-Feb_2009)
EnsemblTAF6 - 7q22.1 [CytoView hg19]  TAF6 - 7q22.1 [CytoView hg38]
Mapping of homologs : NCBITAF6 [Mapview hg19]  TAF6 [Mapview hg38]
OMIM602955   617126   
Gene and transcription
Genbank (Entrez)AK097781 AK300005 AK314428 AK315077 AU143362
RefSeq transcript (Entrez)NM_001190415 NM_005641 NM_139122 NM_139123 NM_139315
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAF6
Cluster EST : UnigeneHs.489309 [ NCBI ]
CGAP (NCI)Hs.489309
Alternative Splicing GalleryENSG00000106290
Gene ExpressionTAF6 [ NCBI-GEO ]   TAF6 [ EBI - ARRAY_EXPRESS ]   TAF6 [ SEEK ]   TAF6 [ MEM ]
Gene Expression Viewer (FireBrowse)TAF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6878
GTEX Portal (Tissue expression)TAF6
Human Protein AtlasENSG00000106290-TAF6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49848   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49848  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49848
Splice isoforms : SwissVarP49848
PhosPhoSitePlusP49848
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Histone-fold    TAF6_C    TAF_TATA-bd   
Domain families : Pfam (Sanger)TAF (PF02969)    TAF6_C (PF07571)   
Domain families : Pfam (NCBI)pfam02969    pfam07571   
Domain families : Smart (EMBL)TAF (SM00803)  
Conserved Domain (NCBI)TAF6
DMDM Disease mutations6878
Blocks (Seattle)TAF6
PDB (SRS)5FUR   
PDB (PDBSum)5FUR   
PDB (IMB)5FUR   
PDB (RSDB)5FUR   
Structural Biology KnowledgeBase5FUR   
SCOP (Structural Classification of Proteins)5FUR   
CATH (Classification of proteins structures)5FUR   
SuperfamilyP49848
Human Protein Atlas [tissue]ENSG00000106290-TAF6 [tissue]
Peptide AtlasP49848
HPRD11807
IPIIPI00939352   
Protein Interaction databases
DIP (DOE-UCLA)P49848
IntAct (EBI)P49848
FunCoupENSG00000106290
BioGRIDTAF6
STRING (EMBL)TAF6
ZODIACTAF6
Ontologies - Pathways
QuickGOP49848
Ontology : AmiGODNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription factor TFIID complex  cytosol  DNA-templated transcription, initiation  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  aryl hydrocarbon receptor binding  transcription factor TFTC complex  snRNA transcription from RNA polymerase II promoter  protein complex  negative regulation of cell cycle  protein heterodimerization activity  regulation of sequence-specific DNA binding transcription factor activity  MLL1 complex  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription factor TFIID complex  cytosol  DNA-templated transcription, initiation  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  aryl hydrocarbon receptor binding  transcription factor TFTC complex  snRNA transcription from RNA polymerase II promoter  protein complex  negative regulation of cell cycle  protein heterodimerization activity  regulation of sequence-specific DNA binding transcription factor activity  MLL1 complex  regulation of signal transduction by p53 class mediator  
Pathways : KEGGBasal transcription factors    Herpes simplex infection   
NDEx NetworkTAF6
Atlas of Cancer Signalling NetworkTAF6
Wikipedia pathwaysTAF6
Orthology - Evolution
OrthoDB6878
GeneTree (enSembl)ENSG00000106290
Phylogenetic Trees/Animal Genes : TreeFamTAF6
HOVERGENP49848
HOGENOMP49848
Homologs : HomoloGeneTAF6
Homology/Alignments : Family Browser (UCSC)TAF6
Gene fusions - Rearrangements
Tumor Fusion PortalTAF6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAF6
dbVarTAF6
ClinVarTAF6
1000_GenomesTAF6 
Exome Variant ServerTAF6
ExAC (Exome Aggregation Consortium)ENSG00000106290
GNOMAD BrowserENSG00000106290
Genetic variants : HAPMAP6878
Genomic Variants (DGV)TAF6 [DGVbeta]
DECIPHERTAF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAF6 
Mutations
ICGC Data PortalTAF6 
TCGA Data PortalTAF6 
Broad Tumor PortalTAF6
OASIS PortalTAF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAF6
DgiDB (Drug Gene Interaction Database)TAF6
DoCM (Curated mutations)TAF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAF6 (select a term)
intoGenTAF6
Cancer3DTAF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602955    617126   
Orphanet
DisGeNETTAF6
MedgenTAF6
Genetic Testing Registry TAF6
NextProtP49848 [Medical]
TSGene6878
GENETestsTAF6
Target ValidationTAF6
Huge Navigator TAF6 [HugePedia]
snp3D : Map Gene to Disease6878
BioCentury BCIQTAF6
ClinGenTAF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6878
Chemical/Pharm GKB GenePA36315
Clinical trialTAF6
Miscellaneous
canSAR (ICR)TAF6 (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAF6
EVEXTAF6
GoPubMedTAF6
iHOPTAF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:17:24 CET 2017

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