Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TAF6 (TATA-box binding protein associated factor 6)

Identity

Alias (NCBI)ALYUS
MGC:8964
TAF(II)70
TAF(II)80
TAF2E
TAFII-70
TAFII-80
TAFII70
TAFII80
TAFII85
HGNC (Hugo) TAF6
HGNC Alias symbTAFII70
TAFII80
MGC:8964
TAFII85
HGNC Alias nameTAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80 kD
 transcription initiation factor TFIID 70 kD subunit
HGNC Previous nameTAF2E
HGNC Previous nameTATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
LocusID (NCBI) 6878
Atlas_Id 74472
Location 7q22.1  [Link to chromosome band 7q22]
Location_base_pair Starts at 100107070 and ends at 100119358 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AP4M1 (7q22.1) / TAF6 (7q22.1)TRIM4 (7q22.1) / TAF6 (7q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TAF6   11540
Cards
Entrez_Gene (NCBI)TAF6    TATA-box binding protein associated factor 6
AliasesALYUS; MGC:8964; TAF(II)70; TAF(II)80; 
TAF2E; TAFII-70; TAFII-80; TAFII70; TAFII80; TAFII85
GeneCards (Weizmann)TAF6
Ensembl hg19 (Hinxton)ENSG00000106290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106290 [Gene_View]  ENSG00000106290 [Sequence]  chr7:100107070-100119358 [Contig_View]  TAF6 [Vega]
ICGC DataPortalENSG00000106290
TCGA cBioPortalTAF6
AceView (NCBI)TAF6
Genatlas (Paris)TAF6
SOURCE (Princeton)TAF6
Genetics Home Reference (NIH)TAF6
Genomic and cartography
GoldenPath hg38 (UCSC)TAF6  -     chr7:100107070-100119358 -  7q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAF6  -     7q22.1   [Description]    (hg19-Feb_2009)
GoldenPathTAF6 - 7q22.1 [CytoView hg19]  TAF6 - 7q22.1 [CytoView hg38]
ImmunoBaseENSG00000106290
Genome Data Viewer NCBITAF6 [Mapview hg19]  
OMIM602955   617126   
Gene and transcription
Genbank (Entrez)AK097781 AK300005 AK314428 AK315077 AU143362
RefSeq transcript (Entrez)NM_001190415 NM_001364998 NM_001364999 NM_001365000 NM_001365001 NM_001365002 NM_001365003 NM_001365004 NM_005641 NM_139122 NM_139123 NM_139315
Consensus coding sequences : CCDS (NCBI)TAF6
Gene ExpressionTAF6 [ NCBI-GEO ]   TAF6 [ EBI - ARRAY_EXPRESS ]   TAF6 [ SEEK ]   TAF6 [ MEM ]
Gene Expression Viewer (FireBrowse)TAF6 [ Firebrowse - Broad ]
GenevisibleExpression of TAF6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6878
GTEX Portal (Tissue expression)TAF6
Human Protein AtlasENSG00000106290-TAF6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49848   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49848  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49848
PhosPhoSitePlusP49848
Domains : Interpro (EBI)ARM-type_fold    Histone-fold    TAF6    TAF6_C    TAF_TATA-bd   
Domain families : Pfam (Sanger)TAF (PF02969)    TAF6_C (PF07571)   
Domain families : Pfam (NCBI)pfam02969    pfam07571   
Domain families : Smart (EMBL)TAF (SM00803)  
Conserved Domain (NCBI)TAF6
PDB (RSDB)5FUR    6F3T    6MZC    6MZD    6MZL    6MZM   
PDB Europe5FUR    6F3T    6MZC    6MZD    6MZL    6MZM   
PDB (PDBSum)5FUR    6F3T    6MZC    6MZD    6MZL    6MZM   
PDB (IMB)5FUR    6F3T    6MZC    6MZD    6MZL    6MZM   
Structural Biology KnowledgeBase5FUR    6F3T    6MZC    6MZD    6MZL    6MZM   
SCOP (Structural Classification of Proteins)5FUR    6F3T    6MZC    6MZD    6MZL    6MZM   
CATH (Classification of proteins structures)5FUR    6F3T    6MZC    6MZD    6MZL    6MZM   
SuperfamilyP49848
AlphaFold pdb e-kbP49848   
Human Protein Atlas [tissue]ENSG00000106290-TAF6 [tissue]
HPRD11807
Protein Interaction databases
DIP (DOE-UCLA)P49848
IntAct (EBI)P49848
BioGRIDTAF6
STRING (EMBL)TAF6
ZODIACTAF6
Ontologies - Pathways
QuickGOP49848
Ontology : AmiGOSAGA complex  DNA binding  transcription coactivator activity  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIID complex  transcription factor TFIID complex  cytosol  DNA-templated transcription, initiation  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  apoptotic process  RNA polymerase II general transcription initiation factor activity  RNA polymerase II general transcription initiation factor activity  RNA polymerase II general transcription initiation factor activity  histone acetylation  aryl hydrocarbon receptor binding  protein-containing complex  transcription factor TFTC complex  snRNA transcription by RNA polymerase II  negative regulation of cell cycle  positive regulation of transcription by RNA polymerase II  SLIK (SAGA-like) complex  protein heterodimerization activity  MLL1 complex  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBISAGA complex  DNA binding  transcription coactivator activity  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIID complex  transcription factor TFIID complex  cytosol  DNA-templated transcription, initiation  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  apoptotic process  RNA polymerase II general transcription initiation factor activity  RNA polymerase II general transcription initiation factor activity  RNA polymerase II general transcription initiation factor activity  histone acetylation  aryl hydrocarbon receptor binding  protein-containing complex  transcription factor TFTC complex  snRNA transcription by RNA polymerase II  negative regulation of cell cycle  positive regulation of transcription by RNA polymerase II  SLIK (SAGA-like) complex  protein heterodimerization activity  MLL1 complex  regulation of signal transduction by p53 class mediator  
Pathways : KEGGBasal transcription factors   
NDEx NetworkTAF6
Atlas of Cancer Signalling NetworkTAF6
Wikipedia pathwaysTAF6
Orthology - Evolution
OrthoDB6878
GeneTree (enSembl)ENSG00000106290
Phylogenetic Trees/Animal Genes : TreeFamTAF6
Homologs : HomoloGeneTAF6
Homology/Alignments : Family Browser (UCSC)TAF6
Gene fusions - Rearrangements
Fusion : QuiverTAF6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAF6
dbVarTAF6
ClinVarTAF6
MonarchTAF6
1000_GenomesTAF6 
Exome Variant ServerTAF6
GNOMAD BrowserENSG00000106290
Varsome BrowserTAF6
ACMGTAF6 variants
VarityP49848
Genomic Variants (DGV)TAF6 [DGVbeta]
DECIPHERTAF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAF6 
Mutations
ICGC Data PortalTAF6 
TCGA Data PortalTAF6 
Broad Tumor PortalTAF6
OASIS PortalTAF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAF6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTAF6
Mutations and Diseases : HGMDTAF6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTAF6
DgiDB (Drug Gene Interaction Database)TAF6
DoCM (Curated mutations)TAF6
CIViC (Clinical Interpretations of Variants in Cancer)TAF6
Cancer3DTAF6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602955    617126   
Orphanet
DisGeNETTAF6
MedgenTAF6
Genetic Testing Registry TAF6
NextProtP49848 [Medical]
GENETestsTAF6
Target ValidationTAF6
Huge Navigator TAF6 [HugePedia]
ClinGenTAF6
Clinical trials, drugs, therapy
MyCancerGenomeTAF6
Protein Interactions : CTDTAF6
Pharm GKB GenePA36315
PharosP49848
Clinical trialTAF6
Miscellaneous
canSAR (ICR)TAF6
HarmonizomeTAF6
DataMed IndexTAF6
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTAF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:24:48 CEST 2021

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