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TAF8 (TATA-box binding protein associated factor 8)

Identity

Alias_namesTBN
TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa
taube nuss homolog (mouse)
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
Alias_symbol (synonym)FLJ32821
TAF(II)43
Other aliasII
TAF
TAFII-43
TAFII43
HGNC (Hugo) TAF8
LocusID (NCBI) 129685
Atlas_Id 54683
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 42050513 and ends at 42080906 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BAG6 (6p21.33) / TAF8 (6p21.1)C1orf146 (1p22.1) / TAF8 (6p21.1)DIP2B (12q13.12) / TAF8 (6p21.1)
TAF8 (6p21.1) / CRISP1 (6p12.3)TAF8 (6p21.1) / CRK (17p13.3)TAF8 (6p21.1) / TAF8 (6p21.1)
TAF8 (6p21.1) / ZMYND8 (20q13.12)USP49 (6p21.1) / TAF8 (6p21.1)BAG6 6p21.33 / TAF8 6p21.1
DIP2B 12q13.12 / TAF8 6p21.1TAF8 6p21.1 / CRISP1 6p12.3USP49 6p21.1 / TAF8 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;6)(q25;p21) LEF1/TAF8


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(6;6)(p12;p21) TAF8/CRISP1
BAG6/TAF8 (6p21)
USP49/TAF8 (6p21)
t(6;12)(p21;q13) DIP2B/TAF8


External links

Nomenclature
HGNC (Hugo)TAF8   17300
Cards
Entrez_Gene (NCBI)TAF8  129685  TATA-box binding protein associated factor 8
AliasesII; TAF; TAF(II)43; TAFII-43; 
TAFII43; TBN
GeneCards (Weizmann)TAF8
Ensembl hg19 (Hinxton)ENSG00000137413 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137413 [Gene_View]  ENSG00000137413 [Sequence]  chr6:42050513-42080906 [Contig_View]  TAF8 [Vega]
ICGC DataPortalENSG00000137413
TCGA cBioPortalTAF8
AceView (NCBI)TAF8
Genatlas (Paris)TAF8
WikiGenes129685
SOURCE (Princeton)TAF8
Genetics Home Reference (NIH)TAF8
Genomic and cartography
GoldenPath hg38 (UCSC)TAF8  -     chr6:42050513-42080906 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAF8  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblTAF8 - 6p21.1 [CytoView hg19]  TAF8 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBITAF8 [Mapview hg19]  TAF8 [Mapview hg38]
OMIM609514   
Gene and transcription
Genbank (Entrez)AF086309 AF465841 AK057383 AK303097 AL833401
RefSeq transcript (Entrez)NM_138572
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAF8
Cluster EST : UnigeneHs.520122 [ NCBI ]
CGAP (NCI)Hs.520122
Alternative Splicing GalleryENSG00000137413
Gene ExpressionTAF8 [ NCBI-GEO ]   TAF8 [ EBI - ARRAY_EXPRESS ]   TAF8 [ SEEK ]   TAF8 [ MEM ]
Gene Expression Viewer (FireBrowse)TAF8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)129685
GTEX Portal (Tissue expression)TAF8
Human Protein AtlasENSG00000137413-TAF8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z7C8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z7C8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z7C8
Splice isoforms : SwissVarQ7Z7C8
PhosPhoSitePlusQ7Z7C8
Domains : Interpro (EBI)BTP    Histone-fold    TAF8    TFIID_su8_C   
Domain families : Pfam (Sanger)Bromo_TP (PF07524)    TAF8_C (PF10406)   
Domain families : Pfam (NCBI)pfam07524    pfam10406   
Domain families : Smart (EMBL)BTP (SM00576)  
Conserved Domain (NCBI)TAF8
DMDM Disease mutations129685
Blocks (Seattle)TAF8
PDB (SRS)4WV4    4WV6    5FUR   
PDB (PDBSum)4WV4    4WV6    5FUR   
PDB (IMB)4WV4    4WV6    5FUR   
PDB (RSDB)4WV4    4WV6    5FUR   
Structural Biology KnowledgeBase4WV4    4WV6    5FUR   
SCOP (Structural Classification of Proteins)4WV4    4WV6    5FUR   
CATH (Classification of proteins structures)4WV4    4WV6    5FUR   
SuperfamilyQ7Z7C8
Human Protein Atlas [tissue]ENSG00000137413-TAF8 [tissue]
Peptide AtlasQ7Z7C8
HPRD18167
IPIIPI00878968   IPI00065313   IPI00879798   IPI00384290   IPI00946673   IPI00946323   IPI00946852   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z7C8
IntAct (EBI)Q7Z7C8
FunCoupENSG00000137413
BioGRIDTAF8
STRING (EMBL)TAF8
ZODIACTAF8
Ontologies - Pathways
QuickGOQ7Z7C8
Ontology : AmiGOinner cell mass cell proliferation  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor TFIID complex  cell differentiation  snRNA transcription by RNA polymerase II  regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  protein heterodimerization activity  perinuclear region of cytoplasm  maintenance of protein location in nucleus  
Ontology : EGO-EBIinner cell mass cell proliferation  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor TFIID complex  cell differentiation  snRNA transcription by RNA polymerase II  regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  protein heterodimerization activity  perinuclear region of cytoplasm  maintenance of protein location in nucleus  
Pathways : KEGGBasal transcription factors   
NDEx NetworkTAF8
Atlas of Cancer Signalling NetworkTAF8
Wikipedia pathwaysTAF8
Orthology - Evolution
OrthoDB129685
GeneTree (enSembl)ENSG00000137413
Phylogenetic Trees/Animal Genes : TreeFamTAF8
HOVERGENQ7Z7C8
HOGENOMQ7Z7C8
Homologs : HomoloGeneTAF8
Homology/Alignments : Family Browser (UCSC)TAF8
Gene fusions - Rearrangements
Fusion : MitelmanBAG6/TAF8 [6p21.33/6p21.1]  [t(6;6)(p21;p21)]  
Fusion : MitelmanDIP2B/TAF8 [12q13.12/6p21.1]  [t(6;12)(p21;q13)]  
Fusion : MitelmanTAF8/CRISP1 [6p21.1/6p12.3]  [t(6;6)(p12;p21)]  
Fusion : MitelmanUSP49/TAF8 [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion PortalBAG6 6p21.33 TAF8 6p21.1 LUSC
Fusion PortalDIP2B 12q13.12 TAF8 6p21.1 GBM
Fusion PortalTAF8 6p21.1 CRISP1 6p12.3 LUAD
Fusion PortalUSP49 6p21.1 TAF8 6p21.1 KIRC
Fusion : QuiverTAF8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAF8
dbVarTAF8
ClinVarTAF8
1000_GenomesTAF8 
Exome Variant ServerTAF8
ExAC (Exome Aggregation Consortium)ENSG00000137413
GNOMAD BrowserENSG00000137413
Varsome BrowserTAF8
Genetic variants : HAPMAP129685
Genomic Variants (DGV)TAF8 [DGVbeta]
DECIPHERTAF8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAF8 
Mutations
ICGC Data PortalTAF8 
TCGA Data PortalTAF8 
Broad Tumor PortalTAF8
OASIS PortalTAF8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAF8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAF8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAF8
DgiDB (Drug Gene Interaction Database)TAF8
DoCM (Curated mutations)TAF8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAF8 (select a term)
intoGenTAF8
Cancer3DTAF8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609514   
Orphanet
DisGeNETTAF8
MedgenTAF8
Genetic Testing Registry TAF8
NextProtQ7Z7C8 [Medical]
TSGene129685
GENETestsTAF8
Target ValidationTAF8
Huge Navigator TAF8 [HugePedia]
snp3D : Map Gene to Disease129685
BioCentury BCIQTAF8
ClinGenTAF8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD129685
Chemical/Pharm GKB GenePA162405144
Clinical trialTAF8
Miscellaneous
canSAR (ICR)TAF8 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAF8
EVEXTAF8
GoPubMedTAF8
iHOPTAF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:43:33 CET 2018

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