TAGLN2 (transgelin 2)

2010-03-01  

Identity

HGNC
LOCATION
1q23.2
LOCUSID
ALIAS
HA1756
FUSION GENES

Other Information

Locus ID:

NCBI: 8407
MIM: 604634
HGNC: 11554
Ensembl: ENSG00000158710

Variants:

dbSNP: 8407
ClinVar: 8407
TCGA: ENSG00000158710
COSMIC: TAGLN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158710ENST00000320307P37802
ENSG00000158710ENST00000320307A0A384MTL2
ENSG00000158710ENST00000368096P37802
ENSG00000158710ENST00000368097P37802
ENSG00000158710ENST00000368097A0A384MTL2
ENSG00000158710ENST00000397334X6RJP6

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213784092011miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma.79
198484162009Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma.32
244763572014Transgelins, cytoskeletal proteins implicated in different aspects of cancer development.28
264147252016The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma.23
215772062011A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility.18
261767342015Salvianolic acid A reverses the paclitaxel resistance and inhibits the migration and invasion abilities of human breast cancer cells by inactivating transgelin 2.14
254214102015miR-133a mediates the hypoxia-induced apoptosis by inhibiting TAGLN2 expression in cardiac myocytes.13
260818362015Comparative Tissue Proteomics of Microdissected Specimens Reveals Novel Candidate Biomarkers of Bladder Cancer.13
291106822017TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas.11
268914542016Functional significance of transgelin-2 in uterine cervical squamous cell carcinoma.10

Citation

Dessen P

TAGLN2 (transgelin 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51377/tagln2