TAGLN2 (transgelin 2)

2010-03-01  

Identity

HGNC
LOCATION
1q23.2
LOCUSID
ALIAS
HA1756
FUSION GENES

Other Information

Locus ID:

NCBI: 8407
MIM: 604634
HGNC: 11554
Ensembl: ENSG00000158710

Variants:

dbSNP: 8407
ClinVar: 8407
TCGA: ENSG00000158710
COSMIC: TAGLN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158710ENST00000320307P37802
ENSG00000158710ENST00000320307A0A384MTL2
ENSG00000158710ENST00000368096P37802
ENSG00000158710ENST00000368097P37802
ENSG00000158710ENST00000368097A0A384MTL2
ENSG00000158710ENST00000397334X6RJP6

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
387443882024TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.0
387443882024TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.0
362227552023TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis.4
365477682023TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.2
372471322023Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.4
362227552023TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis.4
365477682023TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.2
372471322023Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.4
344985382022Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis.7
345533392022Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.6
356830192022Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients.0
344985382022Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis.7
345533392022Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.6
356830192022Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients.0
350113062021Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?3

Citation

Dessen P

TAGLN2 (transgelin 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51377/tagln2