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TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2)

Identity

Alias_symbol (synonym)DKFZP564D166
FLJ10215
FLJ11824
KIAA1148
KIAA1636
rols
ROLSA
Other alias
HGNC (Hugo) TANC2
LocusID (NCBI) 26115
Atlas_Id 53914
Location 17q23.2  [Link to chromosome band 17q23]
Location_base_pair Starts at 63009537 and ends at 63427706 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BRIP1 (17q23.2) / TANC2 (17q23.2)MED13 (17q23.2) / TANC2 (17q23.2)MPDU1 (17p13.1) / TANC2 (17q23.2)
RUNX1T1 (8q21.3) / TANC2 (17q23.2)SEPT9 (17q25.2) / TANC2 (17q23.2)TANC2 (17q23.2) / ANKFN1 (17q22)
TANC2 (17q23.2) / CA4 (17q23.1)TANC2 (17q23.2) / CHD6 (20q12)TANC2 (17q23.2) / CRB3 (19p13.3)
TANC2 (17q23.2) / EFCAB3 (17q23.2)TANC2 (17q23.2) / FAM222B (17q11.2)TANC2 (17q23.2) / GOSR1 (17q11.2)
TANC2 (17q23.2) / KRT10 (17q21.2)TANC2 (17q23.2) / LRRC37B (17q11.2)TANC2 (17q23.2) / PHB (17q21.33)
TANC2 (17q23.2) / PRKCA (17q24.2)TANC2 (17q23.2) / SPAG9 (17q21.33)TANC2 (17q23.2) / SSH2 (17q11.2)
TANC2 (17q23.2) / STRADA (17q23.3)TANC2 (17q23.2) / TANC2 (17q23.2)MED13 17q23.2 / TANC2 17q23.2
SEPT9 17q25.2 / TANC2 17q23.2TANC2 17q23.2 / ANKFN1 17q22TANC2 17q23.2 C17orf63
TANC2 17q23.2 / CHD6 20q12TANC2 17q23.2 / CRB3 19p13.3TANC2 17q23.2 / EFCAB3 17q23.2
TANC2 17q23.2 / GOSR1 17q11.2TANC2 17q23.2 / KRT10 17q21.2TANC2 17q23.2 / LRRC37B 17q11.2
TANC2 17q23.2 / PHB 17q21.33TANC2 17q23.2 / PRKCA 17q24.2TANC2 17q23.2 / SPAG9 17q21.33
TANC2 17q23.2 / SSH2 17q11.2TANC2 17q23.2 / STRADA 17q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TANC2   30212
Cards
Entrez_Gene (NCBI)TANC2  26115  tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
AliasesROLSA; rols
GeneCards (Weizmann)TANC2
Ensembl hg19 (Hinxton)ENSG00000170921 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170921 [Gene_View]  chr17:63009537-63427706 [Contig_View]  TANC2 [Vega]
ICGC DataPortalENSG00000170921
TCGA cBioPortalTANC2
AceView (NCBI)TANC2
Genatlas (Paris)TANC2
WikiGenes26115
SOURCE (Princeton)TANC2
Genetics Home Reference (NIH)TANC2
Genomic and cartography
GoldenPath hg38 (UCSC)TANC2  -     chr17:63009537-63427706 +  17q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TANC2  -     17q23.2   [Description]    (hg19-Feb_2009)
EnsemblTANC2 - 17q23.2 [CytoView hg19]  TANC2 - 17q23.2 [CytoView hg38]
Mapping of homologs : NCBITANC2 [Mapview hg19]  TANC2 [Mapview hg38]
OMIM615047   
Gene and transcription
Genbank (Entrez)AB032974 AB046856 AJ278120 AK001077 AK021886
RefSeq transcript (Entrez)NM_015623 NM_025185 NM_030658
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TANC2
Cluster EST : UnigeneHs.410889 [ NCBI ]
CGAP (NCI)Hs.410889
Alternative Splicing GalleryENSG00000170921
Gene ExpressionTANC2 [ NCBI-GEO ]   TANC2 [ EBI - ARRAY_EXPRESS ]   TANC2 [ SEEK ]   TANC2 [ MEM ]
Gene Expression Viewer (FireBrowse)TANC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26115
GTEX Portal (Tissue expression)TANC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCD6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCD6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCD6
Splice isoforms : SwissVarQ9HCD6
PhosPhoSitePlusQ9HCD6
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    P-loop_NTPase    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam00023    pfam12796    pfam13181   
Domain families : Smart (EMBL)ANK (SM00248)  TPR (SM00028)  
Conserved Domain (NCBI)TANC2
DMDM Disease mutations26115
Blocks (Seattle)TANC2
SuperfamilyQ9HCD6
Human Protein AtlasENSG00000170921
Peptide AtlasQ9HCD6
IPIIPI00868787   IPI00894531   IPI00893434   IPI00892805   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCD6
IntAct (EBI)Q9HCD6
FunCoupENSG00000170921
BioGRIDTANC2
STRING (EMBL)TANC2
ZODIACTANC2
Ontologies - Pathways
QuickGOQ9HCD6
Ontology : AmiGOin utero embryonic development  
Ontology : EGO-EBIin utero embryonic development  
NDEx NetworkTANC2
Atlas of Cancer Signalling NetworkTANC2
Wikipedia pathwaysTANC2
Orthology - Evolution
OrthoDB26115
GeneTree (enSembl)ENSG00000170921
Phylogenetic Trees/Animal Genes : TreeFamTANC2
HOVERGENQ9HCD6
HOGENOMQ9HCD6
Homologs : HomoloGeneTANC2
Homology/Alignments : Family Browser (UCSC)TANC2
Gene fusions - Rearrangements
Fusion : MitelmanMED13/TANC2 [17q23.2/17q23.2]  [t(17;17)(q23;q23)]  
Fusion : MitelmanSEPT9/TANC2 [17q25.2/17q23.2]  [t(17;17)(q23;q25)]  
Fusion : MitelmanTANC2/ANKFN1 [17q23.2/17q22]  [t(17;17)(q22;q23)]  
Fusion : MitelmanTANC2/CHD6 [17q23.2/20q12]  [t(17;20)(q23;q12)]  
Fusion : MitelmanTANC2/CRB3 [17q23.2/19p13.3]  [t(17;19)(q23;p13)]  
Fusion : MitelmanTANC2/EFCAB3 [17q23.2/17q23.2]  [t(17;17)(q23;q23)]  
Fusion : MitelmanTANC2/FAM222B [17q23.2/17q11.2]  [t(17;17)(q11;q23)]  
Fusion : MitelmanTANC2/GOSR1 [17q23.2/17q11.2]  [t(17;17)(q11;q23)]  
Fusion : MitelmanTANC2/KRT10 [17q23.2/17q21.2]  [t(17;17)(q21;q23)]  
Fusion : MitelmanTANC2/LRRC37B [17q23.2/17q11.2]  [t(17;17)(q11;q23)]  
Fusion : MitelmanTANC2/PHB [17q23.2/17q21.33]  [t(17;17)(q21;q23)]  
Fusion : MitelmanTANC2/PRKCA [17q23.2/17q24.2]  [t(17;17)(q23;q24)]  
Fusion : MitelmanTANC2/SPAG9 [17q23.2/17q21.33]  [t(17;17)(q21;q23)]  
Fusion : MitelmanTANC2/SSH2 [17q23.2/17q11.2]  [t(17;17)(q11;q23)]  
Fusion : MitelmanTANC2/STRADA [17q23.2/17q23.3]  [t(17;17)(q23;q23)]  
Fusion: TCGAMED13 17q23.2 TANC2 17q23.2 BRCA
Fusion: TCGASEPT9 17q25.2 TANC2 17q23.2 BRCA
Fusion: TCGATANC2 17q23.2 ANKFN1 17q22 BRCA
Fusion: TCGATANC2 17q23.2 C17orf63 BRCA
Fusion: TCGATANC2 17q23.2 CHD6 20q12 BRCA
Fusion: TCGATANC2 17q23.2 CRB3 19p13.3 LUAD
Fusion: TCGATANC2 17q23.2 EFCAB3 17q23.2 BRCA
Fusion: TCGATANC2 17q23.2 GOSR1 17q11.2 BRCA
Fusion: TCGATANC2 17q23.2 KRT10 17q21.2 BRCA
Fusion: TCGATANC2 17q23.2 LRRC37B 17q11.2 BRCA
Fusion: TCGATANC2 17q23.2 PHB 17q21.33 BRCA
Fusion: TCGATANC2 17q23.2 PRKCA 17q24.2 LUSC
Fusion: TCGATANC2 17q23.2 SPAG9 17q21.33 LUAD
Fusion: TCGATANC2 17q23.2 SSH2 17q11.2 BRCA
Fusion: TCGATANC2 17q23.2 STRADA 17q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTANC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TANC2
dbVarTANC2
ClinVarTANC2
1000_GenomesTANC2 
Exome Variant ServerTANC2
ExAC (Exome Aggregation Consortium)TANC2 (select the gene name)
Genetic variants : HAPMAP26115
Genomic Variants (DGV)TANC2 [DGVbeta]
DECIPHERTANC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTANC2 
Mutations
ICGC Data PortalTANC2 
TCGA Data PortalTANC2 
Broad Tumor PortalTANC2
OASIS PortalTANC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTANC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTANC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TANC2
DgiDB (Drug Gene Interaction Database)TANC2
DoCM (Curated mutations)TANC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TANC2 (select a term)
intoGenTANC2
Cancer3DTANC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615047   
Orphanet
MedgenTANC2
Genetic Testing Registry TANC2
NextProtQ9HCD6 [Medical]
TSGene26115
GENETestsTANC2
Target ValidationTANC2
Huge Navigator TANC2 [HugePedia]
snp3D : Map Gene to Disease26115
BioCentury BCIQTANC2
ClinGenTANC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26115
Chemical/Pharm GKB GenePA142670837
Clinical trialTANC2
Miscellaneous
canSAR (ICR)TANC2 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTANC2
EVEXTANC2
GoPubMedTANC2
iHOPTANC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:16:22 CEST 2017

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