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TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2)

Identity

Alias (NCBI)IDDALDS
ROLSA
rols
HGNC (Hugo) TANC2
HGNC Alias symbDKFZP564D166
FLJ10215
FLJ11824
KIAA1148
KIAA1636
rols
ROLSA
HGNC Alias namerolling pebbles homolog B (Drosophila)
LocusID (NCBI) 26115
Atlas_Id 53914
Location 17q23.2  [Link to chromosome band 17q23]
Location_base_pair Starts at 62966235 and ends at 63427701 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRIP1 (17q23.2) / TANC2 (17q23.2)MED13 (17q23.2) / TANC2 (17q23.2)MPDU1 (17p13.1) / TANC2 (17q23.2)
RUNX1T1 (8q21.3) / TANC2 (17q23.2)SEPT9 (17q25.2) / TANC2 (17q23.2)TANC2 (17q23.2) / ANKFN1 (17q22)
TANC2 (17q23.2) / CA4 (17q23.1)TANC2 (17q23.2) / CHD6 (20q12)TANC2 (17q23.2) / CRB3 (19p13.3)
TANC2 (17q23.2) / EFCAB3 (17q23.2)TANC2 (17q23.2) / FAM222B (17q11.2)TANC2 (17q23.2) / GOSR1 (17q11.2)
TANC2 (17q23.2) / KRT10 (17q21.2)TANC2 (17q23.2) / LRRC37B (17q11.2)TANC2 (17q23.2) / PHB (17q21.33)
TANC2 (17q23.2) / PRKCA (17q24.2)TANC2 (17q23.2) / SPAG9 (17q21.33)TANC2 (17q23.2) / SSH2 (17q11.2)
TANC2 (17q23.2) / STRADA (17q23.3)TANC2 (17q23.2) / TANC2 (17q23.2)MED13 17q23.2 / TANC2 17q23.2
SEPT9 17q25.2 / TANC2 17q23.2TANC2 17q23.2 / ANKFN1 17q22TANC2 17q23.2 C17orf63
TANC2 17q23.2 / CHD6 20q12TANC2 17q23.2 / CRB3 19p13.3TANC2 17q23.2 / EFCAB3 17q23.2
TANC2 17q23.2 / GOSR1 17q11.2TANC2 17q23.2 / KRT10 17q21.2TANC2 17q23.2 / LRRC37B 17q11.2
TANC2 17q23.2 / PHB 17q21.33TANC2 17q23.2 / PRKCA 17q24.2TANC2 17q23.2 / SPAG9 17q21.33
TANC2 17q23.2 / SSH2 17q11.2TANC2 17q23.2 / STRADA 17q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TANC2   30212
Cards
Entrez_Gene (NCBI)TANC2    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
AliasesIDDALDS; ROLSA; rols
GeneCards (Weizmann)TANC2
Ensembl hg19 (Hinxton)ENSG00000170921 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170921 [Gene_View]  ENSG00000170921 [Sequence]  chr17:62966235-63427701 [Contig_View]  TANC2 [Vega]
ICGC DataPortalENSG00000170921
TCGA cBioPortalTANC2
AceView (NCBI)TANC2
Genatlas (Paris)TANC2
SOURCE (Princeton)TANC2
Genetics Home Reference (NIH)TANC2
Genomic and cartography
GoldenPath hg38 (UCSC)TANC2  -     chr17:62966235-63427701 +  17q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TANC2  -     17q23.2   [Description]    (hg19-Feb_2009)
GoldenPathTANC2 - 17q23.2 [CytoView hg19]  TANC2 - 17q23.2 [CytoView hg38]
ImmunoBaseENSG00000170921
Genome Data Viewer NCBITANC2 [Mapview hg19]  
OMIM615047   618906   
Gene and transcription
Genbank (Entrez)AB032974 AB046856 AJ278120 AK001077 AK021886
RefSeq transcript (Entrez)NM_001394998 NM_015623 NM_025185 NM_030658
Consensus coding sequences : CCDS (NCBI)TANC2
Gene ExpressionTANC2 [ NCBI-GEO ]   TANC2 [ EBI - ARRAY_EXPRESS ]   TANC2 [ SEEK ]   TANC2 [ MEM ]
Gene Expression Viewer (FireBrowse)TANC2 [ Firebrowse - Broad ]
GenevisibleExpression of TANC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26115
GTEX Portal (Tissue expression)TANC2
Human Protein AtlasENSG00000170921-TANC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCD6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCD6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCD6
PhosPhoSitePlusQ9HCD6
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    P-loop_NTPase    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam00023    pfam12796    pfam13181   
Domain families : Smart (EMBL)ANK (SM00248)  TPR (SM00028)  
Conserved Domain (NCBI)TANC2
SuperfamilyQ9HCD6
AlphaFold pdb e-kbQ9HCD6   
Human Protein Atlas [tissue]ENSG00000170921-TANC2 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q9HCD6
IntAct (EBI)Q9HCD6
BioGRIDTANC2
STRING (EMBL)TANC2
ZODIACTANC2
Ontologies - Pathways
QuickGOQ9HCD6
Ontology : AmiGOin utero embryonic development  axon  dendritic spine  regulation of dendritic spine development  regulation of dendritic spine morphogenesis  dense core granule cytoskeletal transport  
Ontology : EGO-EBIin utero embryonic development  axon  dendritic spine  regulation of dendritic spine development  regulation of dendritic spine morphogenesis  dense core granule cytoskeletal transport  
NDEx NetworkTANC2
Atlas of Cancer Signalling NetworkTANC2
Wikipedia pathwaysTANC2
Orthology - Evolution
OrthoDB26115
GeneTree (enSembl)ENSG00000170921
Phylogenetic Trees/Animal Genes : TreeFamTANC2
Homologs : HomoloGeneTANC2
Homology/Alignments : Family Browser (UCSC)TANC2
Gene fusions - Rearrangements
Fusion : MitelmanMED13/TANC2 [17q23.2/17q23.2]  
Fusion : MitelmanSEPT9/TANC2 [17q25.2/17q23.2]  
Fusion : MitelmanTANC2/ANKFN1 [17q23.2/17q22]  
Fusion : MitelmanTANC2/CHD6 [17q23.2/20q12]  
Fusion : MitelmanTANC2/CRB3 [17q23.2/19p13.3]  
Fusion : MitelmanTANC2/EFCAB3 [17q23.2/17q23.2]  
Fusion : MitelmanTANC2/FAM222B [17q23.2/17q11.2]  
Fusion : MitelmanTANC2/GOSR1 [17q23.2/17q11.2]  
Fusion : MitelmanTANC2/KRT10 [17q23.2/17q21.2]  
Fusion : MitelmanTANC2/LRRC37B [17q23.2/17q11.2]  
Fusion : MitelmanTANC2/PHB [17q23.2/17q21.33]  
Fusion : MitelmanTANC2/PRKCA [17q23.2/17q24.2]  
Fusion : MitelmanTANC2/SPAG9 [17q23.2/17q21.33]  
Fusion : MitelmanTANC2/SSH2 [17q23.2/17q11.2]  
Fusion : MitelmanTANC2/STRADA [17q23.2/17q23.3]  
Fusion : QuiverTANC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTANC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TANC2
dbVarTANC2
ClinVarTANC2
MonarchTANC2
1000_GenomesTANC2 
Exome Variant ServerTANC2
GNOMAD BrowserENSG00000170921
Varsome BrowserTANC2
ACMGTANC2 variants
VarityQ9HCD6
Genomic Variants (DGV)TANC2 [DGVbeta]
DECIPHERTANC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTANC2 
Mutations
ICGC Data PortalTANC2 
TCGA Data PortalTANC2 
Broad Tumor PortalTANC2
OASIS PortalTANC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTANC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTANC2
Mutations and Diseases : HGMDTANC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTANC2
DgiDB (Drug Gene Interaction Database)TANC2
DoCM (Curated mutations)TANC2
CIViC (Clinical Interpretations of Variants in Cancer)TANC2
Cancer3DTANC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615047    618906   
Orphanet
DisGeNETTANC2
MedgenTANC2
Genetic Testing Registry TANC2
NextProtQ9HCD6 [Medical]
GENETestsTANC2
Target ValidationTANC2
Huge Navigator TANC2 [HugePedia]
ClinGenTANC2
Clinical trials, drugs, therapy
MyCancerGenomeTANC2
Protein Interactions : CTDTANC2
Pharm GKB GenePA142670837
PharosQ9HCD6
Clinical trialTANC2
Miscellaneous
canSAR (ICR)TANC2
HarmonizomeTANC2
DataMed IndexTANC2
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTANC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:13 CEST 2021

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