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TANK (TRAF family member associated NFKB activator)

Identity

Alias_namesTRAF2
TRAF family member-associated NFKB activator
Alias_symbol (synonym)I-TRAF
Other aliasITRAF
HGNC (Hugo) TANK
LocusID (NCBI) 10010
Atlas_Id 42468
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 161160428 and ends at 161236172 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGB6 (2q24.2) / TANK (2q24.2)NBEAL1 (2q33.2) / TANK (2q24.2)TANK (2q24.2) / MNAT1 (14q23.1)
TANK (2q24.2) / SLC38A6 (14q23.1)ZNF800 (7q31.33) / TANK (2q24.2)NBEAL1 2q33.2 / TANK 2q24.2
TANK 2q24.2 / MNAT1 14q23.1TANK 2q24.2 / SLC38A6 14q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TANK   11562
Cards
Entrez_Gene (NCBI)TANK  10010  TRAF family member associated NFKB activator
AliasesI-TRAF; ITRAF; TRAF2
GeneCards (Weizmann)TANK
Ensembl hg19 (Hinxton)ENSG00000136560 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136560 [Gene_View]  chr2:161160428-161236172 [Contig_View]  TANK [Vega]
ICGC DataPortalENSG00000136560
TCGA cBioPortalTANK
AceView (NCBI)TANK
Genatlas (Paris)TANK
WikiGenes10010
SOURCE (Princeton)TANK
Genetics Home Reference (NIH)TANK
Genomic and cartography
GoldenPath hg38 (UCSC)TANK  -     chr2:161160428-161236172 +  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TANK  -     2q24.2   [Description]    (hg19-Feb_2009)
EnsemblTANK - 2q24.2 [CytoView hg19]  TANK - 2q24.2 [CytoView hg38]
Mapping of homologs : NCBITANK [Mapview hg19]  TANK [Mapview hg38]
OMIM603893   
Gene and transcription
Genbank (Entrez)AK313096 BC003388 BC067779 BT009855 U59863
RefSeq transcript (Entrez)NM_001199135 NM_004180 NM_133484
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TANK
Cluster EST : UnigeneHs.132257 [ NCBI ]
CGAP (NCI)Hs.132257
Alternative Splicing GalleryENSG00000136560
Gene ExpressionTANK [ NCBI-GEO ]   TANK [ EBI - ARRAY_EXPRESS ]   TANK [ SEEK ]   TANK [ MEM ]
Gene Expression Viewer (FireBrowse)TANK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10010
GTEX Portal (Tissue expression)TANK
Human Protein AtlasENSG00000136560-TANK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92844   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92844  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92844
Splice isoforms : SwissVarQ92844
PhosPhoSitePlusQ92844
Domains : Interpro (EBI)TBD   
Domain families : Pfam (Sanger)TBD (PF12845)   
Domain families : Pfam (NCBI)pfam12845   
Conserved Domain (NCBI)TANK
DMDM Disease mutations10010
Blocks (Seattle)TANK
PDB (SRS)1KZZ    1L0A   
PDB (PDBSum)1KZZ    1L0A   
PDB (IMB)1KZZ    1L0A   
PDB (RSDB)1KZZ    1L0A   
Structural Biology KnowledgeBase1KZZ    1L0A   
SCOP (Structural Classification of Proteins)1KZZ    1L0A   
CATH (Classification of proteins structures)1KZZ    1L0A   
SuperfamilyQ92844
Human Protein Atlas [tissue]ENSG00000136560-TANK [tissue]
Peptide AtlasQ92844
HPRD04870
IPIIPI00299166   IPI00375988   IPI00894040   IPI00893904   IPI00893789   IPI00893594   IPI00893511   IPI00893370   IPI00893243   IPI00893173   IPI00893061   IPI00892936   IPI00892829   IPI00917956   
Protein Interaction databases
DIP (DOE-UCLA)Q92844
IntAct (EBI)Q92844
FunCoupENSG00000136560
BioGRIDTANK
STRING (EMBL)TANK
ZODIACTANK
Ontologies - Pathways
QuickGOQ92844
Ontology : AmiGOthiol-dependent ubiquitin-specific protease activity  protein binding  cytosol  cytosol  proteolysis  cellular response to DNA damage stimulus  signal transduction  I-kappaB kinase/NF-kappaB signaling  viral process  ubiquitin protein ligase binding  TRIF-dependent toll-like receptor signaling pathway  deubiquitinase activator activity  negative regulation of I-kappaB kinase/NF-kappaB signaling  protein complex  metal ion binding  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to ionizing radiation  positive regulation of protein deubiquitination  positive regulation of ubiquitin-specific protease activity  
Ontology : EGO-EBIthiol-dependent ubiquitin-specific protease activity  protein binding  cytosol  cytosol  proteolysis  cellular response to DNA damage stimulus  signal transduction  I-kappaB kinase/NF-kappaB signaling  viral process  ubiquitin protein ligase binding  TRIF-dependent toll-like receptor signaling pathway  deubiquitinase activator activity  negative regulation of I-kappaB kinase/NF-kappaB signaling  protein complex  metal ion binding  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to ionizing radiation  positive regulation of protein deubiquitination  positive regulation of ubiquitin-specific protease activity  
Pathways : BIOCARTATNFR2 Signaling Pathway [Genes]    TNF/Stress Related Signaling [Genes]   
Pathways : KEGGRIG-I-like receptor signaling pathway   
NDEx NetworkTANK
Atlas of Cancer Signalling NetworkTANK
Wikipedia pathwaysTANK
Orthology - Evolution
OrthoDB10010
GeneTree (enSembl)ENSG00000136560
Phylogenetic Trees/Animal Genes : TreeFamTANK
HOVERGENQ92844
HOGENOMQ92844
Homologs : HomoloGeneTANK
Homology/Alignments : Family Browser (UCSC)TANK
Gene fusions - Rearrangements
Fusion : MitelmanNBEAL1/TANK [2q33.2/2q24.2]  [t(2;2)(q24;q33)]  
Fusion : MitelmanTANK/MNAT1 [2q24.2/14q23.1]  [t(2;14)(q24;q23)]  
Fusion : MitelmanTANK/SLC38A6 [2q24.2/14q23.1]  [t(2;14)(q24;q23)]  
Fusion: TCGANBEAL1 2q33.2 TANK 2q24.2 BRCA
Fusion: TCGATANK 2q24.2 MNAT1 14q23.1 LUSC
Fusion: TCGATANK 2q24.2 SLC38A6 14q23.1 LUSC
Fusion: Tumor Portal TANK
Fusion Cancer (Beijing)ITGB6 [2q24.2]  -  TANK [2q24.2]  [FUSC000290]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTANK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TANK
dbVarTANK
ClinVarTANK
1000_GenomesTANK 
Exome Variant ServerTANK
ExAC (Exome Aggregation Consortium)ENSG00000136560
GNOMAD BrowserENSG00000136560
Genetic variants : HAPMAP10010
Genomic Variants (DGV)TANK [DGVbeta]
DECIPHERTANK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTANK 
Mutations
ICGC Data PortalTANK 
TCGA Data PortalTANK 
Broad Tumor PortalTANK
OASIS PortalTANK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTANK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTANK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TANK
DgiDB (Drug Gene Interaction Database)TANK
DoCM (Curated mutations)TANK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TANK (select a term)
intoGenTANK
Cancer3DTANK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603893   
Orphanet
MedgenTANK
Genetic Testing Registry TANK
NextProtQ92844 [Medical]
TSGene10010
GENETestsTANK
Target ValidationTANK
Huge Navigator TANK [HugePedia]
snp3D : Map Gene to Disease10010
BioCentury BCIQTANK
ClinGenTANK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10010
Chemical/Pharm GKB GenePA36330
Clinical trialTANK
Miscellaneous
canSAR (ICR)TANK (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTANK
EVEXTANK
GoPubMedTANK
iHOPTANK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:13:42 CET 2017

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