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TANK (TRAF family member associated NFKB activator)

Identity

Alias (NCBI)I-TRAF
ITRAF
TRAF2
HGNC (Hugo) TANK
HGNC Alias symbI-TRAF
HGNC Previous nameTRAF2
HGNC Previous nameTRAF family member-associated NFKB activator
LocusID (NCBI) 10010
Atlas_Id 42468
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 161136955 and ends at 161204979 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ITGB6 (2q24.2) / TANK (2q24.2)NBEAL1 (2q33.2) / TANK (2q24.2)TANK (2q24.2) / MNAT1 (14q23.1)
TANK (2q24.2) / SLC38A6 (14q23.1)ZNF800 (7q31.33) / TANK (2q24.2)NBEAL1 2q33.2 / TANK 2q24.2
TANK 2q24.2 / MNAT1 14q23.1TANK 2q24.2 / SLC38A6 14q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TANK   11562
Cards
Entrez_Gene (NCBI)TANK    TRAF family member associated NFKB activator
AliasesI-TRAF; ITRAF; TRAF2
GeneCards (Weizmann)TANK
Ensembl hg19 (Hinxton)ENSG00000136560 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136560 [Gene_View]  ENSG00000136560 [Sequence]  chr2:161136955-161204979 [Contig_View]  TANK [Vega]
ICGC DataPortalENSG00000136560
TCGA cBioPortalTANK
AceView (NCBI)TANK
Genatlas (Paris)TANK
SOURCE (Princeton)TANK
Genetics Home Reference (NIH)TANK
Genomic and cartography
GoldenPath hg38 (UCSC)TANK  -     chr2:161136955-161204979 +  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TANK  -     2q24.2   [Description]    (hg19-Feb_2009)
GoldenPathTANK - 2q24.2 [CytoView hg19]  TANK - 2q24.2 [CytoView hg38]
ImmunoBaseENSG00000136560
Genome Data Viewer NCBITANK [Mapview hg19]  
OMIM603893   
Gene and transcription
Genbank (Entrez)AK313096 BC003388 BC067779 BT009855 U59863
RefSeq transcript (Entrez)NM_001199135 NM_004180 NM_133484
Consensus coding sequences : CCDS (NCBI)TANK
Gene ExpressionTANK [ NCBI-GEO ]   TANK [ EBI - ARRAY_EXPRESS ]   TANK [ SEEK ]   TANK [ MEM ]
Gene Expression Viewer (FireBrowse)TANK [ Firebrowse - Broad ]
GenevisibleExpression of TANK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10010
GTEX Portal (Tissue expression)TANK
Human Protein AtlasENSG00000136560-TANK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92844   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92844  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92844
PhosPhoSitePlusQ92844
Domaine pattern : Prosite (Expaxy)ZF_UBZ1 (PS51905)   
Domains : Interpro (EBI)CALCOCO1/2_Zn_UBZ1    TANK    TBD   
Domain families : Pfam (Sanger)TBD (PF12845)   
Domain families : Pfam (NCBI)pfam12845   
Conserved Domain (NCBI)TANK
PDB (RSDB)1KZZ    1L0A    5H10   
PDB Europe1KZZ    1L0A    5H10   
PDB (PDBSum)1KZZ    1L0A    5H10   
PDB (IMB)1KZZ    1L0A    5H10   
Structural Biology KnowledgeBase1KZZ    1L0A    5H10   
SCOP (Structural Classification of Proteins)1KZZ    1L0A    5H10   
CATH (Classification of proteins structures)1KZZ    1L0A    5H10   
SuperfamilyQ92844
AlphaFold pdb e-kbQ92844   
Human Protein Atlas [tissue]ENSG00000136560-TANK [tissue]
HPRD04870
Protein Interaction databases
DIP (DOE-UCLA)Q92844
IntAct (EBI)Q92844
BioGRIDTANK
STRING (EMBL)TANK
ZODIACTANK
Ontologies - Pathways
QuickGOQ92844
Ontology : AmiGOthiol-dependent deubiquitinase  protein binding  cytosol  cytosol  proteolysis  cellular response to DNA damage stimulus  signal transduction  I-kappaB kinase/NF-kappaB signaling  ubiquitin protein ligase binding  protein-containing complex  TRIF-dependent toll-like receptor signaling pathway  deubiquitinase activator activity  negative regulation of I-kappaB kinase/NF-kappaB signaling  metal ion binding  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to ionizing radiation  positive regulation of protein deubiquitination  positive regulation of ubiquitin-specific protease activity  
Ontology : EGO-EBIthiol-dependent deubiquitinase  protein binding  cytosol  cytosol  proteolysis  cellular response to DNA damage stimulus  signal transduction  I-kappaB kinase/NF-kappaB signaling  ubiquitin protein ligase binding  protein-containing complex  TRIF-dependent toll-like receptor signaling pathway  deubiquitinase activator activity  negative regulation of I-kappaB kinase/NF-kappaB signaling  metal ion binding  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to ionizing radiation  positive regulation of protein deubiquitination  positive regulation of ubiquitin-specific protease activity  
Pathways : BIOCARTATNFR2 Signaling Pathway [Genes]    TNF/Stress Related Signaling [Genes]   
Pathways : KEGGRIG-I-like receptor signaling pathway   
NDEx NetworkTANK
Atlas of Cancer Signalling NetworkTANK
Wikipedia pathwaysTANK
Orthology - Evolution
OrthoDB10010
GeneTree (enSembl)ENSG00000136560
Phylogenetic Trees/Animal Genes : TreeFamTANK
Homologs : HomoloGeneTANK
Homology/Alignments : Family Browser (UCSC)TANK
Gene fusions - Rearrangements
Fusion : MitelmanNBEAL1/TANK [2q33.2/2q24.2]  
Fusion : MitelmanTANK/MNAT1 [2q24.2/14q23.1]  
Fusion : MitelmanTANK/SLC38A6 [2q24.2/14q23.1]  
Fusion Cancer (Beijing)ITGB6 [2q24.2]  -  TANK [2q24.2]  [FUSC000290]
Fusion : QuiverTANK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTANK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TANK
dbVarTANK
ClinVarTANK
MonarchTANK
1000_GenomesTANK 
Exome Variant ServerTANK
GNOMAD BrowserENSG00000136560
Varsome BrowserTANK
ACMGTANK variants
VarityQ92844
Genomic Variants (DGV)TANK [DGVbeta]
DECIPHERTANK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTANK 
Mutations
ICGC Data PortalTANK 
TCGA Data PortalTANK 
Broad Tumor PortalTANK
OASIS PortalTANK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTANK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTANK
Mutations and Diseases : HGMDTANK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTANK
DgiDB (Drug Gene Interaction Database)TANK
DoCM (Curated mutations)TANK
CIViC (Clinical Interpretations of Variants in Cancer)TANK
Cancer3DTANK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603893   
Orphanet
DisGeNETTANK
MedgenTANK
Genetic Testing Registry TANK
NextProtQ92844 [Medical]
GENETestsTANK
Target ValidationTANK
Huge Navigator TANK [HugePedia]
ClinGenTANK
Clinical trials, drugs, therapy
MyCancerGenomeTANK
Protein Interactions : CTDTANK
Pharm GKB GenePA36330
PharosQ92844
Clinical trialTANK
Miscellaneous
canSAR (ICR)TANK
HarmonizomeTANK
DataMed IndexTANK
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTANK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:13 CEST 2021

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