TAOK1 (TAO kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
KFC-B,MAP3K16,MARKK,PSK-2,PSK2,TAO1,hKFC-B,hTAOK1
FUSION GENES

Other Information

Locus ID:

NCBI: 57551
MIM: 610266
HGNC: 29259
Ensembl: ENSG00000160551

Variants:

dbSNP: 57551
ClinVar: 57551
TCGA: ENSG00000160551
COSMIC: TAOK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160551ENST00000261716Q7L7X3
ENSG00000160551ENST00000261716A0A024QZ70
ENSG00000160551ENST00000536202Q7L7X3
ENSG00000160551ENST00000583121J3QS76

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220751482011The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.81
173961462007TAO kinases mediate activation of p38 in response to DNA damage.70
174176292007A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.46
191102112009A genome-wide association study identifies three loci associated with mean platelet volume.41
199045492010Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.33
182162812008Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton.23
201622902010Re-evaluating the role of Tao1 in the spindle checkpoint.18
164073102006Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1.15
235855622013Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.12
248981392014TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes.12

Citation

Dessen P

TAOK1 (TAO kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43525/taok1