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TAOK1 (TAO kinase 1)

Identity

Alias (NCBI)KFC-B
MAP3K16
MARKK
PSK-2
PSK2
TAO1
hKFC-B
hTAOK1
HGNC (Hugo) TAOK1
HGNC Alias symbKIAA1361
MARKK
PSK2
MAP3K16
FLJ14314
TAO1
hTAOK1
hKFC-B
HGNC Alias nameprostate-derived sterile 20-like kinase 2
 MARK kinase
 thousand and one amino acid protein kinase 1
LocusID (NCBI) 57551
Atlas_Id 43525
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 29390925 and ends at 29551903 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC7 (10p11.22) / TAOK1 (17q11.2)ETV6 (12p13.2) / TAOK1 (17q11.2)PAX5 (9p13.2) / TAOK1 (17q11.2)
PKP2 (12p11.21) / TAOK1 (17q11.2)SETD5 (3p25.3) / TAOK1 (17q11.2)SPOP (17q21.33) / TAOK1 (17q11.2)
TAOK1 (17q11.2) / ACER3 (11q13.5)TAOK1 (17q11.2) / BCAS3 (17q23.2)TAOK1 (17q11.2) / CCDC144A (17p11.2)
TAOK1 (17q11.2) / CCL2 (17q12)TAOK1 (17q11.2) / FAM222B (17q11.2)TAOK1 (17q11.2) / FLOT2 (17q11.2)
TAOK1 (17q11.2) / IDS (Xq28)TAOK1 (17q11.2) / PARP10 (8q24.3)TAOK1 (17q11.2) / PCGF2 (17q12)
TAOK1 (17q11.2) / PIPOX (17q11.2)TAOK1 (17q11.2) / RARA (17q21.2)TAOK1 (17q11.2) / RB1CC1 (8q11.23)
TAOK1 (17q11.2) / ZNF385C (17q21.2)ZNF217 (20q13.2) / TAOK1 (17q11.2)SPOP 17q21.33 / TAOK1 17q11.2
TAOK1 17q11.2 / ACER3 11q13.5TAOK1 17q11.2 / BCAS3 17q23.2TAOK1 17q11.2 C17orf63
TAOK1 17q11.2 / CCL2 17q12TAOK1 17q11.2 / FLOT2 17q11.2TAOK1 17q11.2 / PARP10 8q24.3
TAOK1 17q11.2 / PIPOX 17q11.2TAOK1 17q11.2 / RARA 17q21.2TAOK1 17q11.2 / RB1CC1 8q11.23
TAOK1 17q11.2 / ZNF385C 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

 

Nomenclature
HGNC (Hugo)TAOK1   29259
Cards
Entrez_Gene (NCBI)TAOK1    TAO kinase 1
AliasesKFC-B; MAP3K16; MARKK; PSK-2; 
PSK2; TAO1; hKFC-B; hTAOK1
GeneCards (Weizmann)TAOK1
Ensembl hg19 (Hinxton)ENSG00000160551 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160551 [Gene_View]  ENSG00000160551 [Sequence]  chr17:29390925-29551903 [Contig_View]  TAOK1 [Vega]
ICGC DataPortalENSG00000160551
TCGA cBioPortalTAOK1
AceView (NCBI)TAOK1
Genatlas (Paris)TAOK1
SOURCE (Princeton)TAOK1
Genetics Home Reference (NIH)TAOK1
Genomic and cartography
GoldenPath hg38 (UCSC)TAOK1  -     chr17:29390925-29551903 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAOK1  -     17q11.2   [Description]    (hg19-Feb_2009)
GoldenPathTAOK1 - 17q11.2 [CytoView hg19]  TAOK1 - 17q11.2 [CytoView hg38]
ImmunoBaseENSG00000160551
Genome Data Viewer NCBITAOK1 [Mapview hg19]  
OMIM610266   
Gene and transcription
Genbank (Entrez)AB037782 AF263312 AK024376 AK025902 AL110163
RefSeq transcript (Entrez)NM_020791 NM_025142
Consensus coding sequences : CCDS (NCBI)TAOK1
Gene ExpressionTAOK1 [ NCBI-GEO ]   TAOK1 [ EBI - ARRAY_EXPRESS ]   TAOK1 [ SEEK ]   TAOK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TAOK1 [ Firebrowse - Broad ]
GenevisibleExpression of TAOK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57551
GTEX Portal (Tissue expression)TAOK1
Human Protein AtlasENSG00000160551-TAOK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L7X3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L7X3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L7X3
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ7L7X3
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TAOK1
SuperfamilyQ7L7X3
AlphaFold pdb e-kbQ7L7X3   
Human Protein Atlas [tissue]ENSG00000160551-TAOK1 [tissue]
HPRD15467
Protein Interaction databases
DIP (DOE-UCLA)Q7L7X3
IntAct (EBI)Q7L7X3
BioGRIDTAOK1
STRING (EMBL)TAOK1
ZODIACTAOK1
Ontologies - Pathways
QuickGOQ7L7X3
Ontology : AmiGOMAPK cascade  activation of MAPK activity  microtubule cytoskeleton organization  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  DNA repair  protein phosphorylation  protein phosphorylation  cellular response to DNA damage stimulus  negative regulation of microtubule depolymerization  mitotic spindle organization  mitotic G2 DNA damage checkpoint signaling  activation of JUN kinase activity  microtubule cytoskeleton  kinase activity  kinase activity  phosphorylation  transferase activity  activation of protein kinase activity  positive regulation of stress-activated MAPK cascade  regulation of actin cytoskeleton organization  intracellular signal transduction  alpha-tubulin binding  regulation of MAPK cascade  protein serine/threonine kinase activator activity  positive regulation of JNK cascade  protein autophosphorylation  tau protein binding  perinuclear region of cytoplasm  beta-tubulin binding  neuron projection morphogenesis  tau-protein kinase activity  regulation of cytoskeleton organization  neuron cellular homeostasis  extracellular exosome  regulation of microtubule cytoskeleton organization  execution phase of apoptosis  execution phase of apoptosis  protein serine kinase activity  protein threonine kinase activity  positive regulation of protein acetylation  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  microtubule cytoskeleton organization  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  DNA repair  protein phosphorylation  protein phosphorylation  cellular response to DNA damage stimulus  negative regulation of microtubule depolymerization  mitotic spindle organization  mitotic G2 DNA damage checkpoint signaling  activation of JUN kinase activity  microtubule cytoskeleton  kinase activity  kinase activity  phosphorylation  transferase activity  activation of protein kinase activity  positive regulation of stress-activated MAPK cascade  regulation of actin cytoskeleton organization  intracellular signal transduction  alpha-tubulin binding  regulation of MAPK cascade  protein serine/threonine kinase activator activity  positive regulation of JNK cascade  protein autophosphorylation  tau protein binding  perinuclear region of cytoplasm  beta-tubulin binding  neuron projection morphogenesis  tau-protein kinase activity  regulation of cytoskeleton organization  neuron cellular homeostasis  extracellular exosome  regulation of microtubule cytoskeleton organization  execution phase of apoptosis  execution phase of apoptosis  protein serine kinase activity  protein threonine kinase activity  positive regulation of protein acetylation  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkTAOK1
Atlas of Cancer Signalling NetworkTAOK1
Wikipedia pathwaysTAOK1
Orthology - Evolution
OrthoDB57551
GeneTree (enSembl)ENSG00000160551
Phylogenetic Trees/Animal Genes : TreeFamTAOK1
Homologs : HomoloGeneTAOK1
Homology/Alignments : Family Browser (UCSC)TAOK1
Gene fusions - Rearrangements
Fusion : MitelmanPAX5/TAOK1 [9p13.2/17q11.2]  
Fusion : MitelmanSPOP/TAOK1 [17q21.33/17q11.2]  
Fusion : MitelmanTAOK1/ACER3 [17q11.2/11q13.5]  
Fusion : MitelmanTAOK1/BCAS3 [17q11.2/17q23.2]  
Fusion : MitelmanTAOK1/CCL2 [17q11.2/17q12]  
Fusion : MitelmanTAOK1/FAM222B [17q11.2/17q11.2]  
Fusion : MitelmanTAOK1/FLOT2 [17q11.2/17q11.2]  
Fusion : MitelmanTAOK1/PARP10 [17q11.2/8q24.3]  
Fusion : MitelmanTAOK1/PCGF2 [17q11.2/17q12]  
Fusion : MitelmanTAOK1/PIPOX [17q11.2/17q11.2]  
Fusion : MitelmanTAOK1/RARA [17q11.2/17q21.2]  
Fusion : MitelmanTAOK1/RB1CC1 [17q11.2/8q11.23]  
Fusion : MitelmanTAOK1/ZNF385C [17q11.2/17q21.2]  
Fusion : QuiverTAOK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAOK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAOK1
dbVarTAOK1
ClinVarTAOK1
MonarchTAOK1
1000_GenomesTAOK1 
Exome Variant ServerTAOK1
GNOMAD BrowserENSG00000160551
Varsome BrowserTAOK1
ACMGTAOK1 variants
VarityQ7L7X3
Genomic Variants (DGV)TAOK1 [DGVbeta]
DECIPHERTAOK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAOK1 
Mutations
ICGC Data PortalTAOK1 
TCGA Data PortalTAOK1 
Broad Tumor PortalTAOK1
OASIS PortalTAOK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAOK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTAOK1
Mutations and Diseases : HGMDTAOK1
intOGen PortalTAOK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTAOK1
DgiDB (Drug Gene Interaction Database)TAOK1
DoCM (Curated mutations)TAOK1
CIViC (Clinical Interpretations of Variants in Cancer)TAOK1
Cancer3DTAOK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610266   
Orphanet
DisGeNETTAOK1
MedgenTAOK1
Genetic Testing Registry TAOK1
NextProtQ7L7X3 [Medical]
GENETestsTAOK1
Target ValidationTAOK1
Huge Navigator TAOK1 [HugePedia]
ClinGenTAOK1
Clinical trials, drugs, therapy
MyCancerGenomeTAOK1
Protein Interactions : CTDTAOK1
Pharm GKB GenePA134872946
PharosQ7L7X3
Clinical trialTAOK1
Miscellaneous
canSAR (ICR)TAOK1
HarmonizomeTAOK1
DataMed IndexTAOK1
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTAOK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:13 CEST 2021

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