Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TAOK1 (TAO kinase 1)

Identity

Alias_symbol (synonym)KIAA1361
MARKK
PSK2
MAP3K16
FLJ14314
TAO1
Other aliasKFC-B
PSK-2
hKFC-B
hTAOK1
HGNC (Hugo) TAOK1
LocusID (NCBI) 57551
Atlas_Id 43525
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 29390925 and ends at 29551903 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCDC7 (10p11.22) / TAOK1 (17q11.2)ETV6 (12p13.2) / TAOK1 (17q11.2)PAX5 (9p13.2) / TAOK1 (17q11.2)
PKP2 (12p11.21) / TAOK1 (17q11.2)SETD5 (3p25.3) / TAOK1 (17q11.2)SPOP (17q21.33) / TAOK1 (17q11.2)
TAOK1 (17q11.2) / ACER3 (11q13.5)TAOK1 (17q11.2) / BCAS3 (17q23.2)TAOK1 (17q11.2) / CCDC144A (17p11.2)
TAOK1 (17q11.2) / CCL2 (17q12)TAOK1 (17q11.2) / FAM222B (17q11.2)TAOK1 (17q11.2) / FLOT2 (17q11.2)
TAOK1 (17q11.2) / IDS (Xq28)TAOK1 (17q11.2) / PARP10 (8q24.3)TAOK1 (17q11.2) / PCGF2 (17q12)
TAOK1 (17q11.2) / PIPOX (17q11.2)TAOK1 (17q11.2) / RARA (17q21.2)TAOK1 (17q11.2) / RB1CC1 (8q11.23)
TAOK1 (17q11.2) / ZNF385C (17q21.2)ZNF217 (20q13.2) / TAOK1 (17q11.2)SPOP 17q21.33 / TAOK1 17q11.2
TAOK1 17q11.2 / ACER3 11q13.5TAOK1 17q11.2 / BCAS3 17q23.2TAOK1 17q11.2 C17orf63
TAOK1 17q11.2 / CCL2 17q12TAOK1 17q11.2 / FLOT2 17q11.2TAOK1 17q11.2 / PARP10 8q24.3
TAOK1 17q11.2 / PIPOX 17q11.2TAOK1 17q11.2 / RARA 17q21.2TAOK1 17q11.2 / RB1CC1 8q11.23
TAOK1 17q11.2 / ZNF385C 17q21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Protein

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

Nomenclature
HGNC (Hugo)TAOK1   29259
Cards
Entrez_Gene (NCBI)TAOK1  57551  TAO kinase 1
AliasesKFC-B; MAP3K16; MARKK; PSK-2; 
PSK2; TAO1; hKFC-B; hTAOK1
GeneCards (Weizmann)TAOK1
Ensembl hg19 (Hinxton)ENSG00000160551 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160551 [Gene_View]  chr17:29390925-29551903 [Contig_View]  TAOK1 [Vega]
ICGC DataPortalENSG00000160551
TCGA cBioPortalTAOK1
AceView (NCBI)TAOK1
Genatlas (Paris)TAOK1
WikiGenes57551
SOURCE (Princeton)TAOK1
Genetics Home Reference (NIH)TAOK1
Genomic and cartography
GoldenPath hg38 (UCSC)TAOK1  -     chr17:29390925-29551903 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAOK1  -     17q11.2   [Description]    (hg19-Feb_2009)
EnsemblTAOK1 - 17q11.2 [CytoView hg19]  TAOK1 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBITAOK1 [Mapview hg19]  TAOK1 [Mapview hg38]
OMIM610266   
Gene and transcription
Genbank (Entrez)AB037782 AF263312 AK024376 AK025902 AL110163
RefSeq transcript (Entrez)NM_020791 NM_025142
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAOK1
Cluster EST : UnigeneHs.735869 [ NCBI ]
CGAP (NCI)Hs.735869
Alternative Splicing GalleryENSG00000160551
Gene ExpressionTAOK1 [ NCBI-GEO ]   TAOK1 [ EBI - ARRAY_EXPRESS ]   TAOK1 [ SEEK ]   TAOK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TAOK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57551
GTEX Portal (Tissue expression)TAOK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L7X3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L7X3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L7X3
Splice isoforms : SwissVarQ7L7X3
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ7L7X3
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TAOK1
DMDM Disease mutations57551
Blocks (Seattle)TAOK1
SuperfamilyQ7L7X3
Human Protein AtlasENSG00000160551
Peptide AtlasQ7L7X3
HPRD15467
IPIIPI00002232   IPI00654673   
Protein Interaction databases
DIP (DOE-UCLA)Q7L7X3
IntAct (EBI)Q7L7X3
FunCoupENSG00000160551
BioGRIDTAOK1
STRING (EMBL)TAOK1
ZODIACTAOK1
Ontologies - Pathways
QuickGOQ7L7X3
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  DNA repair  protein phosphorylation  cellular response to DNA damage stimulus  sister chromatid cohesion  kinase activity  transferase activity  signal transduction by protein phosphorylation  G2 DNA damage checkpoint  spindle checkpoint  positive regulation of stress-activated MAPK cascade  positive regulation of JNK cascade  regulation of cytoskeleton organization  extracellular exosome  execution phase of apoptosis  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  DNA repair  protein phosphorylation  cellular response to DNA damage stimulus  sister chromatid cohesion  kinase activity  transferase activity  signal transduction by protein phosphorylation  G2 DNA damage checkpoint  spindle checkpoint  positive regulation of stress-activated MAPK cascade  positive regulation of JNK cascade  regulation of cytoskeleton organization  extracellular exosome  execution phase of apoptosis  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkTAOK1
Atlas of Cancer Signalling NetworkTAOK1
Wikipedia pathwaysTAOK1
Orthology - Evolution
OrthoDB57551
GeneTree (enSembl)ENSG00000160551
Phylogenetic Trees/Animal Genes : TreeFamTAOK1
HOVERGENQ7L7X3
HOGENOMQ7L7X3
Homologs : HomoloGeneTAOK1
Homology/Alignments : Family Browser (UCSC)TAOK1
Gene fusions - Rearrangements
Fusion : MitelmanPAX5/TAOK1 [9p13.2/17q11.2]  [t(9;17)(p13;q11)]  
Fusion : MitelmanSPOP/TAOK1 [17q21.33/17q11.2]  [t(17;17)(q11;q21)]  
Fusion : MitelmanTAOK1/ACER3 [17q11.2/11q13.5]  [t(11;17)(q13;q11)]  
Fusion : MitelmanTAOK1/BCAS3 [17q11.2/17q23.2]  [t(17;17)(q11;q23)]  
Fusion : MitelmanTAOK1/CCL2 [17q11.2/17q12]  [t(17;17)(q11;q12)]  
Fusion : MitelmanTAOK1/FAM222B [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion : MitelmanTAOK1/FLOT2 [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion : MitelmanTAOK1/PARP10 [17q11.2/8q24.3]  [t(8;17)(q24;q11)]  
Fusion : MitelmanTAOK1/PCGF2 [17q11.2/17q12]  [t(17;17)(q11;q12)]  
Fusion : MitelmanTAOK1/PIPOX [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion : MitelmanTAOK1/RARA [17q11.2/17q21.2]  [t(17;17)(q11;q21)]  
Fusion : MitelmanTAOK1/RB1CC1 [17q11.2/8q11.23]  [t(8;17)(q11;q11)]  
Fusion : MitelmanTAOK1/ZNF385C [17q11.2/17q21.2]  [t(17;17)(q11;q21)]  
Fusion: TCGASPOP 17q21.33 TAOK1 17q11.2 BRCA
Fusion: TCGATAOK1 17q11.2 ACER3 11q13.5 BRCA
Fusion: TCGATAOK1 17q11.2 BCAS3 17q23.2 LUAD
Fusion: TCGATAOK1 17q11.2 C17orf63 BRCA
Fusion: TCGATAOK1 17q11.2 CCL2 17q12 BRCA
Fusion: TCGATAOK1 17q11.2 FLOT2 17q11.2 BRCA
Fusion: TCGATAOK1 17q11.2 PARP10 8q24.3 BRCA
Fusion: TCGATAOK1 17q11.2 PIPOX 17q11.2 BRCA
Fusion: TCGATAOK1 17q11.2 RARA 17q21.2 GBM
Fusion: TCGATAOK1 17q11.2 RB1CC1 8q11.23 BLCA
Fusion: TCGATAOK1 17q11.2 ZNF385C 17q21.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAOK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAOK1
dbVarTAOK1
ClinVarTAOK1
1000_GenomesTAOK1 
Exome Variant ServerTAOK1
ExAC (Exome Aggregation Consortium)TAOK1 (select the gene name)
Genetic variants : HAPMAP57551
Genomic Variants (DGV)TAOK1 [DGVbeta]
DECIPHERTAOK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAOK1 
Mutations
ICGC Data PortalTAOK1 
TCGA Data PortalTAOK1 
Broad Tumor PortalTAOK1
OASIS PortalTAOK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAOK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAOK1
intOGen PortalTAOK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAOK1
DgiDB (Drug Gene Interaction Database)TAOK1
DoCM (Curated mutations)TAOK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAOK1 (select a term)
intoGenTAOK1
Cancer3DTAOK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610266   
Orphanet
MedgenTAOK1
Genetic Testing Registry TAOK1
NextProtQ7L7X3 [Medical]
TSGene57551
GENETestsTAOK1
Huge Navigator TAOK1 [HugePedia]
snp3D : Map Gene to Disease57551
BioCentury BCIQTAOK1
ClinGenTAOK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57551
Chemical/Pharm GKB GenePA134872946
Clinical trialTAOK1
Miscellaneous
canSAR (ICR)TAOK1 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAOK1
EVEXTAOK1
GoPubMedTAOK1
iHOPTAOK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:40:11 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.