Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TAOK2 (TAO kinase 2)

Identity

Alias_symbol (synonym)TAO1
KIAA0881
PSK
PSK1
TAO2
MAP3K17
Other aliasPSK1-BETA
HGNC (Hugo) TAOK2
LocusID (NCBI) 9344
Atlas_Id 47560
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 29973867 and ends at 29988405 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TMEM219 (16p11.2) / TAOK2 (16p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

Nomenclature
HGNC (Hugo)TAOK2   16835
Cards
Entrez_Gene (NCBI)TAOK2  9344  TAO kinase 2
AliasesMAP3K17; PSK; PSK1; PSK1-BETA; 
TAO1; TAO2
GeneCards (Weizmann)TAOK2
Ensembl hg19 (Hinxton)ENSG00000149930 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149930 [Gene_View]  chr16:29973867-29988405 [Contig_View]  TAOK2 [Vega]
ICGC DataPortalENSG00000149930
TCGA cBioPortalTAOK2
AceView (NCBI)TAOK2
Genatlas (Paris)TAOK2
WikiGenes9344
SOURCE (Princeton)TAOK2
Genetics Home Reference (NIH)TAOK2
Genomic and cartography
GoldenPath hg38 (UCSC)TAOK2  -     chr16:29973867-29988405 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAOK2  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblTAOK2 - 16p11.2 [CytoView hg19]  TAOK2 - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBITAOK2 [Mapview hg19]  TAOK2 [Mapview hg38]
OMIM613199   
Gene and transcription
Genbank (Entrez)AB020688 AF061943 AF263313 AI805725 AK057589
RefSeq transcript (Entrez)NM_001252043 NM_004783 NM_016151
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAOK2
Cluster EST : UnigeneHs.291623 [ NCBI ]
CGAP (NCI)Hs.291623
Alternative Splicing GalleryENSG00000149930
Gene ExpressionTAOK2 [ NCBI-GEO ]   TAOK2 [ EBI - ARRAY_EXPRESS ]   TAOK2 [ SEEK ]   TAOK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TAOK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9344
GTEX Portal (Tissue expression)TAOK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UL54   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UL54  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UL54
Splice isoforms : SwissVarQ9UL54
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9UL54
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TAOK2
DMDM Disease mutations9344
Blocks (Seattle)TAOK2
SuperfamilyQ9UL54
Human Protein AtlasENSG00000149930
Peptide AtlasQ9UL54
HPRD18147
IPIIPI00465168   IPI00006283   IPI00641071   IPI00922624   IPI00640515   IPI00448764   IPI00979403   
Protein Interaction databases
DIP (DOE-UCLA)Q9UL54
IntAct (EBI)Q9UL54
FunCoupENSG00000149930
BioGRIDTAOK2
STRING (EMBL)TAOK2
ZODIACTAOK2
Ontologies - Pathways
QuickGOQ9UL54
Ontology : AmiGOactivation of MAPKK activity  regulation of cell growth  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  ATP binding  nucleus  nucleolus  cytosol  cytoskeleton  protein targeting to membrane  apoptotic process  response to stress  cellular response to DNA damage stimulus  regulation of cell shape  integral component of membrane  cell migration  actin cytoskeleton organization  dendrite  cytoplasmic vesicle membrane  cytoplasmic vesicle  mitogen-activated protein kinase kinase binding  G2 DNA damage checkpoint  positive regulation of stress-activated MAPK cascade  receptor complex  positive regulation of JNK cascade  focal adhesion assembly  stress-activated MAPK cascade  
Ontology : EGO-EBIactivation of MAPKK activity  regulation of cell growth  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  ATP binding  nucleus  nucleolus  cytosol  cytoskeleton  protein targeting to membrane  apoptotic process  response to stress  cellular response to DNA damage stimulus  regulation of cell shape  integral component of membrane  cell migration  actin cytoskeleton organization  dendrite  cytoplasmic vesicle membrane  cytoplasmic vesicle  mitogen-activated protein kinase kinase binding  G2 DNA damage checkpoint  positive regulation of stress-activated MAPK cascade  receptor complex  positive regulation of JNK cascade  focal adhesion assembly  stress-activated MAPK cascade  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkTAOK2
Atlas of Cancer Signalling NetworkTAOK2
Wikipedia pathwaysTAOK2
Orthology - Evolution
OrthoDB9344
GeneTree (enSembl)ENSG00000149930
Phylogenetic Trees/Animal Genes : TreeFamTAOK2
HOVERGENQ9UL54
HOGENOMQ9UL54
Homologs : HomoloGeneTAOK2
Homology/Alignments : Family Browser (UCSC)TAOK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAOK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAOK2
dbVarTAOK2
ClinVarTAOK2
1000_GenomesTAOK2 
Exome Variant ServerTAOK2
ExAC (Exome Aggregation Consortium)TAOK2 (select the gene name)
Genetic variants : HAPMAP9344
Genomic Variants (DGV)TAOK2 [DGVbeta]
DECIPHERTAOK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAOK2 
Mutations
ICGC Data PortalTAOK2 
TCGA Data PortalTAOK2 
Broad Tumor PortalTAOK2
OASIS PortalTAOK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAOK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAOK2
intOGen PortalTAOK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAOK2
DgiDB (Drug Gene Interaction Database)TAOK2
DoCM (Curated mutations)TAOK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAOK2 (select a term)
intoGenTAOK2
Cancer3DTAOK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613199   
Orphanet
MedgenTAOK2
Genetic Testing Registry TAOK2
NextProtQ9UL54 [Medical]
TSGene9344
GENETestsTAOK2
Huge Navigator TAOK2 [HugePedia]
snp3D : Map Gene to Disease9344
BioCentury BCIQTAOK2
ClinGenTAOK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9344
Chemical/Pharm GKB GenePA134907964
Clinical trialTAOK2
Miscellaneous
canSAR (ICR)TAOK2 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAOK2
EVEXTAOK2
GoPubMedTAOK2
iHOPTAOK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:40:11 CEST 2017

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