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TAP2 (transporter 2, ATP binding cassette subfamily B member)

Identity

Alias_namesABCB3
transporter 2
Alias_symbol (synonym)PSF2
RING11
D6S217E
Other aliasABC18
APT2
PSF-2
HGNC (Hugo) TAP2
LocusID (NCBI) 6891
Atlas_Id 43829
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32825410 and ends at 32838770 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TAP2 (6p21.32) / VARS (6p21.33)TAP2 6p21.32 / VARS 6p21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TAP2   44
LRG (Locus Reference Genomic)LRG_167
Cards
Entrez_Gene (NCBI)TAP2  6891  transporter 2, ATP binding cassette subfamily B member
AliasesABC18; ABCB3; APT2; D6S217E; 
PSF-2; PSF2; RING11
GeneCards (Weizmann)TAP2
Ensembl hg19 (Hinxton)ENSG00000204267 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204267 [Gene_View]  chr6:32825410-32838770 [Contig_View]  TAP2 [Vega]
ICGC DataPortalENSG00000204267
TCGA cBioPortalTAP2
AceView (NCBI)TAP2
Genatlas (Paris)TAP2
WikiGenes6891
SOURCE (Princeton)TAP2
Genetics Home Reference (NIH)TAP2
Genomic and cartography
GoldenPath hg38 (UCSC)TAP2  -     chr6:32825410-32838770 -  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAP2  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblTAP2 - 6p21.32 [CytoView hg19]  TAP2 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBITAP2 [Mapview hg19]  TAP2 [Mapview hg38]
OMIM170261   604571   
Gene and transcription
Genbank (Entrez)AB073779 AB208953 AF078671 AF105151 AF152583
RefSeq transcript (Entrez)NM_000544 NM_001290043 NM_018833
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_009793 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)TAP2
Cluster EST : UnigeneHs.502 [ NCBI ]
CGAP (NCI)Hs.502
Alternative Splicing GalleryENSG00000204267
Gene ExpressionTAP2 [ NCBI-GEO ]   TAP2 [ EBI - ARRAY_EXPRESS ]   TAP2 [ SEEK ]   TAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)TAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6891
GTEX Portal (Tissue expression)TAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03519   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03519  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03519
Splice isoforms : SwissVarQ03519
PhosPhoSitePlusQ03519
Domaine pattern : Prosite (Expaxy)ABC_TM1F (PS50929)    ABC_TRANSPORTER_1 (PS00211)    ABC_TRANSPORTER_2 (PS50893)   
Domains : Interpro (EBI)AAA+_ATPase    ABC1_TM_dom    ABC_Tap-like    ABC_transporter-like    ABC_transporter_CS    P-loop_NTPase    Tap2/ABCB3   
Domain families : Pfam (Sanger)ABC_membrane (PF00664)    ABC_tran (PF00005)   
Domain families : Pfam (NCBI)pfam00664    pfam00005   
Domain families : Smart (EMBL)AAA (SM00382)  
Conserved Domain (NCBI)TAP2
DMDM Disease mutations6891
Blocks (Seattle)TAP2
PDB (SRS)5U1D   
PDB (PDBSum)5U1D   
PDB (IMB)5U1D   
PDB (RSDB)5U1D   
Structural Biology KnowledgeBase5U1D   
SCOP (Structural Classification of Proteins)5U1D   
CATH (Classification of proteins structures)5U1D   
SuperfamilyQ03519
Human Protein AtlasENSG00000204267
Peptide AtlasQ03519
HPRD01360
IPIIPI00328112   IPI00001382   IPI01022602   IPI00816634   IPI00892682   IPI00894511   IPI00893353   IPI00796611   
Protein Interaction databases
DIP (DOE-UCLA)Q03519
IntAct (EBI)Q03519
FunCoupENSG00000204267
BioGRIDTAP2
STRING (EMBL)TAP2
ZODIACTAP2
Ontologies - Pathways
QuickGOQ03519
Ontology : AmiGOadaptive immune response  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent  transporter activity  protein binding  ATP binding  ATP binding  endoplasmic reticulum  endoplasmic reticulum membrane  peptide transporter activity  peptide antigen-transporting ATPase activity  membrane  integral component of membrane  nuclear speck  intracellular transport of viral protein in host cell  antigen processing and presentation of endogenous peptide antigen via MHC class I  antigen processing and presentation of endogenous peptide antigen via MHC class I  MHC class Ib protein binding  integral component of endoplasmic reticulum membrane  phagocytic vesicle membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  TAP complex  host cell  cytosol to ER transport  peptide antigen transport  peptide antigen transport  TAP1 binding  tapasin binding  transmembrane transport  vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  
Ontology : EGO-EBIadaptive immune response  antigen processing and presentation of peptide antigen via MHC class I  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent  antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent  transporter activity  protein binding  ATP binding  ATP binding  endoplasmic reticulum  endoplasmic reticulum membrane  peptide transporter activity  peptide antigen-transporting ATPase activity  membrane  integral component of membrane  nuclear speck  intracellular transport of viral protein in host cell  antigen processing and presentation of endogenous peptide antigen via MHC class I  antigen processing and presentation of endogenous peptide antigen via MHC class I  MHC class Ib protein binding  integral component of endoplasmic reticulum membrane  phagocytic vesicle membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  TAP complex  host cell  cytosol to ER transport  peptide antigen transport  peptide antigen transport  TAP1 binding  tapasin binding  transmembrane transport  vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  
Pathways : BIOCARTAAntigen Processing and Presentation [Genes]   
Pathways : KEGGABC transporters    Phagosome    Antigen processing and presentation    Herpes simplex infection    Primary immunodeficiency   
NDEx NetworkTAP2
Atlas of Cancer Signalling NetworkTAP2
Wikipedia pathwaysTAP2
Orthology - Evolution
OrthoDB6891
GeneTree (enSembl)ENSG00000204267
Phylogenetic Trees/Animal Genes : TreeFamTAP2
HOVERGENQ03519
HOGENOMQ03519
Homologs : HomoloGeneTAP2
Homology/Alignments : Family Browser (UCSC)TAP2
Gene fusions - Rearrangements
Fusion : MitelmanTAP2/VARS [6p21.32/6p21.33]  
Fusion: TCGATAP2 6p21.32 VARS 6p21.33 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAP2
dbVarTAP2
ClinVarTAP2
1000_GenomesTAP2 
Exome Variant ServerTAP2
ExAC (Exome Aggregation Consortium)TAP2 (select the gene name)
Genetic variants : HAPMAP6891
Genomic Variants (DGV)TAP2 [DGVbeta]
DECIPHERTAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAP2 
Mutations
ICGC Data PortalTAP2 
TCGA Data PortalTAP2 
Broad Tumor PortalTAP2
OASIS PortalTAP2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch TAP2
DgiDB (Drug Gene Interaction Database)TAP2
DoCM (Curated mutations)TAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAP2 (select a term)
intoGenTAP2
Cancer3DTAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM170261    604571   
Orphanet10349   
MedgenTAP2
Genetic Testing Registry TAP2
NextProtQ03519 [Medical]
TSGene6891
GENETestsTAP2
Target ValidationTAP2
Huge Navigator TAP2 [HugePedia]
snp3D : Map Gene to Disease6891
BioCentury BCIQTAP2
ClinGenTAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6891
Chemical/Pharm GKB GenePA35022
Clinical trialTAP2
Miscellaneous
canSAR (ICR)TAP2 (select the gene name)
Probes
Litterature
PubMed188 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAP2
EVEXTAP2
GoPubMedTAP2
iHOPTAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:34:10 CEST 2017

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