TARBP2 (TARBP2 subunit of RISC loading complex)

2007-02-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
LOQS,TRBP,TRBP1,TRBP2

Other Information

Locus ID:

NCBI: 6895
MIM: 605053
HGNC: 11569
Ensembl: ENSG00000139546

Variants:

dbSNP: 6895
ClinVar: 6895
TCGA: ENSG00000139546
COSMIC: TARBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139546ENST00000266987Q15633
ENSG00000139546ENST00000394357Q15633
ENSG00000139546ENST00000456234Q15633
ENSG00000139546ENST00000547064F8VSA1
ENSG00000139546ENST00000548971F8VTT7
ENSG00000139546ENST00000549572F8VYK3
ENSG00000139546ENST00000549679F8VYK6
ENSG00000139546ENST00000550147F8VP94
ENSG00000139546ENST00000550407F8VZ57
ENSG00000139546ENST00000551741F8VZZ7
ENSG00000139546ENST00000552817H3BV98
ENSG00000139546ENST00000552857F8VW32

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927
Small interfering RNA (siRNA) biogenesisREACTOMER-HSA-426486

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386369482024Caspase-mediated processing of TRBP regulates apoptosis during viral infection.0
386369482024Caspase-mediated processing of TRBP regulates apoptosis during viral infection.0
334593402021Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling.7
334842092021TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs.7
350086342021TARBP2 Suppresses Ubiquitin-Proteasomal Degradation of HIF-1α in Breast Cancer.4
334593402021Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling.7
334842092021TARBP2 promotes tumor angiogenesis and metastasis by destabilizing antiangiogenic factor mRNAs.7
350086342021TARBP2 Suppresses Ubiquitin-Proteasomal Degradation of HIF-1α in Breast Cancer.4
317996262020LGP2 virus sensor enhances apoptosis by upregulating apoptosis regulatory genes through TRBP-bound miRNAs during viral infection.14
323059602020Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway.14
317996262020LGP2 virus sensor enhances apoptosis by upregulating apoptosis regulatory genes through TRBP-bound miRNAs during viral infection.14
323059602020Hypoxia-induced let-7f-5p/TARBP2 feedback loop regulates osteosarcoma cell proliferation and invasion by inhibiting the Wnt signaling pathway.14
306572542019TARBP2-mediated destabilization of Nanog overcomes sorafenib resistance in hepatocellular carcinoma.17
309276222019TARBP2 inhibits IRF7 activation by suppressing TRAF6-mediated K63-linked ubiquitination of IRF7.9
313002742019Nuclear TARBP2 Drives Oncogenic Dysregulation of RNA Splicing and Decay.35

Citation

Dessen P

TARBP2 (TARBP2 subunit of RISC loading complex)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45570/tarbp2