Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TARS (threonyl-tRNA synthetase)

Identity

Alias_namescytoplasmic
Other aliasThrRS
HGNC (Hugo) TARS
LocusID (NCBI) 6897
Atlas_Id 55224
Location 5p13.3  [Link to chromosome band 5p13]
Location_base_pair Starts at 33440696 and ends at 33468091 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TARS (5p13.3) / FGFR1OP (6q27)ZFR (5p13.3) / TARS (5p13.3)ZFR 5p13.3 / TARS 5p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TARS   11572
Cards
Entrez_Gene (NCBI)TARS  6897  threonyl-tRNA synthetase
AliasesThrRS
GeneCards (Weizmann)TARS
Ensembl hg19 (Hinxton)ENSG00000113407 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113407 [Gene_View]  chr5:33440696-33468091 [Contig_View]  TARS [Vega]
ICGC DataPortalENSG00000113407
TCGA cBioPortalTARS
AceView (NCBI)TARS
Genatlas (Paris)TARS
WikiGenes6897
SOURCE (Princeton)TARS
Genetics Home Reference (NIH)TARS
Genomic and cartography
GoldenPath hg38 (UCSC)TARS  -     chr5:33440696-33468091 +  5p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TARS  -     5p13.3   [Description]    (hg19-Feb_2009)
EnsemblTARS - 5p13.3 [CytoView hg19]  TARS - 5p13.3 [CytoView hg38]
Mapping of homologs : NCBITARS [Mapview hg19]  TARS [Mapview hg38]
OMIM187790   
Gene and transcription
Genbank (Entrez)AK095852 AK222804 AK292346 AK293620 AK296783
RefSeq transcript (Entrez)NM_001258437 NM_001258438 NM_152295
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TARS
Cluster EST : UnigeneHs.481860 [ NCBI ]
CGAP (NCI)Hs.481860
Alternative Splicing GalleryENSG00000113407
Gene ExpressionTARS [ NCBI-GEO ]   TARS [ EBI - ARRAY_EXPRESS ]   TARS [ SEEK ]   TARS [ MEM ]
Gene Expression Viewer (FireBrowse)TARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6897
GTEX Portal (Tissue expression)TARS
Human Protein AtlasENSG00000113407-TARS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26639
Splice isoforms : SwissVarP26639
Catalytic activity : Enzyme6.1.1.3 [ Enzyme-Expasy ]   6.1.1.36.1.1.3 [ IntEnz-EBI ]   6.1.1.3 [ BRENDA ]   6.1.1.3 [ KEGG ]   
PhosPhoSitePlusP26639
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb    aa-tRNA-synth_II    Anticodon-bd    Beta-grasp_dom    TGS    TGS-like    Thr-tRNA-ligase_IIa    Thr/Ala-tRNA-synth_IIc_edit    ThrRS_core    tRNA_SAD   
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)    TGS (PF02824)    tRNA-synt_2b (PF00587)    tRNA_SAD (PF07973)   
Domain families : Pfam (NCBI)pfam03129    pfam02824    pfam00587    pfam07973   
Domain families : Smart (EMBL)tRNA_SAD (SM00863)  
Conserved Domain (NCBI)TARS
DMDM Disease mutations6897
Blocks (Seattle)TARS
PDB (SRS)1WWT    4HWT    4P3N    4TTV   
PDB (PDBSum)1WWT    4HWT    4P3N    4TTV   
PDB (IMB)1WWT    4HWT    4P3N    4TTV   
PDB (RSDB)1WWT    4HWT    4P3N    4TTV   
Structural Biology KnowledgeBase1WWT    4HWT    4P3N    4TTV   
SCOP (Structural Classification of Proteins)1WWT    4HWT    4P3N    4TTV   
CATH (Classification of proteins structures)1WWT    4HWT    4P3N    4TTV   
SuperfamilyP26639
Human Protein Atlas [tissue]ENSG00000113407-TARS [tissue]
Peptide AtlasP26639
HPRD01762
IPIIPI00329633   IPI01012172   IPI00910719   IPI00965896   IPI00908949   IPI00966149   IPI00965598   IPI00967989   IPI00966983   IPI00965253   IPI00966670   
Protein Interaction databases
DIP (DOE-UCLA)P26639
IntAct (EBI)P26639
FunCoupENSG00000113407
BioGRIDTARS
STRING (EMBL)TARS
ZODIACTARS
Ontologies - Pathways
QuickGOP26639
Ontology : AmiGOthreonine-tRNA ligase activity  threonine-tRNA ligase activity  threonine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  actin cytoskeleton  protein homodimerization activity  extracellular exosome  
Ontology : EGO-EBIthreonine-tRNA ligase activity  threonine-tRNA ligase activity  threonine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  actin cytoskeleton  protein homodimerization activity  extracellular exosome  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkTARS
Atlas of Cancer Signalling NetworkTARS
Wikipedia pathwaysTARS
Orthology - Evolution
OrthoDB6897
GeneTree (enSembl)ENSG00000113407
Phylogenetic Trees/Animal Genes : TreeFamTARS
HOVERGENP26639
HOGENOMP26639
Homologs : HomoloGeneTARS
Homology/Alignments : Family Browser (UCSC)TARS
Gene fusions - Rearrangements
Fusion : MitelmanZFR/TARS [5p13.3/5p13.3]  [t(5;5)(p13;p13)]  
Fusion: TCGA_MDACCZFR 5p13.3 TARS 5p13.3 BRCA
Tumor Fusion PortalTARS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TARS
dbVarTARS
ClinVarTARS
1000_GenomesTARS 
Exome Variant ServerTARS
ExAC (Exome Aggregation Consortium)ENSG00000113407
GNOMAD BrowserENSG00000113407
Genetic variants : HAPMAP6897
Genomic Variants (DGV)TARS [DGVbeta]
DECIPHERTARS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTARS 
Mutations
ICGC Data PortalTARS 
TCGA Data PortalTARS 
Broad Tumor PortalTARS
OASIS PortalTARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TARS
DgiDB (Drug Gene Interaction Database)TARS
DoCM (Curated mutations)TARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TARS (select a term)
intoGenTARS
Cancer3DTARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187790   
Orphanet
DisGeNETTARS
MedgenTARS
Genetic Testing Registry TARS
NextProtP26639 [Medical]
TSGene6897
GENETestsTARS
Target ValidationTARS
Huge Navigator TARS [HugePedia]
snp3D : Map Gene to Disease6897
BioCentury BCIQTARS
ClinGenTARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6897
Chemical/Pharm GKB GenePA36337
Clinical trialTARS
Miscellaneous
canSAR (ICR)TARS (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTARS
EVEXTARS
GoPubMedTARS
iHOPTARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:37:39 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.