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TARS1 (threonyl-tRNA synthetase 1)

Identity

Alias (NCBI)TARS
TTD7
ThrRS
HGNC (Hugo) TARS1
HGNC Alias namethreonine tRNA ligase 1, cytoplasmic
HGNC Previous nameTARS
HGNC Previous namethreonyl-tRNA synthetase
LocusID (NCBI) 6897
Atlas_Id 55224
Location 5p13.3  [Link to chromosome band 5p13]
Location_base_pair Starts at 33440776 and ends at 33468091 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZFR 5p13.3 / TARS 5p13.3
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute



External links

 

Nomenclature
HGNC (Hugo)TARS1   11572
Cards
Entrez_Gene (NCBI)TARS1    threonyl-tRNA synthetase 1
AliasesTARS; TTD7; ThrRS
GeneCards (Weizmann)TARS1
Ensembl hg19 (Hinxton)ENSG00000113407 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113407 [Gene_View]  ENSG00000113407 [Sequence]  chr5:33440776-33468091 [Contig_View]  TARS1 [Vega]
ICGC DataPortalENSG00000113407
TCGA cBioPortalTARS1
AceView (NCBI)TARS1
Genatlas (Paris)TARS1
SOURCE (Princeton)TARS1
Genetics Home Reference (NIH)TARS1
Genomic and cartography
GoldenPath hg38 (UCSC)TARS1  -     chr5:33440776-33468091 +  5p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TARS1  -     5p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTARS1 - 5p13.3 [CytoView hg19]  TARS1 - 5p13.3 [CytoView hg38]
ImmunoBaseENSG00000113407
Genome Data Viewer NCBITARS1 [Mapview hg19]  
OMIM187790   618546   
Gene and transcription
Genbank (Entrez)AK095852 AK222804 AK292346 AK293620 AK296783
RefSeq transcript (Entrez)NM_001258437 NM_001258438 NM_152295
Consensus coding sequences : CCDS (NCBI)TARS1
Gene ExpressionTARS1 [ NCBI-GEO ]   TARS1 [ EBI - ARRAY_EXPRESS ]   TARS1 [ SEEK ]   TARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)TARS1 [ Firebrowse - Broad ]
GenevisibleExpression of TARS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6897
GTEX Portal (Tissue expression)TARS1
Human Protein AtlasENSG00000113407-TARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26639
PhosPhoSitePlusP26639
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)    TGS (PS51880)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb    aa-tRNA-synth_II    Anticodon-bd    Anticodon-bd_dom_sf    Beta-grasp_dom_sf    TGS    TGS-like    Thr-tRNA-ligase_IIa    Thr/Ala-tRNA-synth_IIc_edit    ThrRS_core    tRNA_SAD   
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)    TGS (PF02824)    tRNA-synt_2b (PF00587)    tRNA_SAD (PF07973)   
Domain families : Pfam (NCBI)pfam03129    pfam02824    pfam00587    pfam07973   
Domain families : Smart (EMBL)tRNA_SAD (SM00863)  
Conserved Domain (NCBI)TARS1
PDB (RSDB)1WWT    4HWT    4P3N    4TTV    5XLN   
PDB Europe1WWT    4HWT    4P3N    4TTV    5XLN   
PDB (PDBSum)1WWT    4HWT    4P3N    4TTV    5XLN   
PDB (IMB)1WWT    4HWT    4P3N    4TTV    5XLN   
Structural Biology KnowledgeBase1WWT    4HWT    4P3N    4TTV    5XLN   
SCOP (Structural Classification of Proteins)1WWT    4HWT    4P3N    4TTV    5XLN   
CATH (Classification of proteins structures)1WWT    4HWT    4P3N    4TTV    5XLN   
SuperfamilyP26639
AlphaFold pdb e-kbP26639   
Human Protein Atlas [tissue]ENSG00000113407-TARS1 [tissue]
HPRD01762
Protein Interaction databases
DIP (DOE-UCLA)P26639
IntAct (EBI)P26639
BioGRIDTARS1
STRING (EMBL)TARS1
ZODIACTARS1
Ontologies - Pathways
QuickGOP26639
Ontology : AmiGOtRNA binding  threonine-tRNA ligase activity  threonine-tRNA ligase activity  threonine-tRNA ligase activity  protein binding  ATP binding  cytosol  tRNA aminoacylation for protein translation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  zinc ion binding  identical protein binding  extracellular exosome  
Ontology : EGO-EBItRNA binding  threonine-tRNA ligase activity  threonine-tRNA ligase activity  threonine-tRNA ligase activity  protein binding  ATP binding  cytosol  tRNA aminoacylation for protein translation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  zinc ion binding  identical protein binding  extracellular exosome  
NDEx NetworkTARS1
Atlas of Cancer Signalling NetworkTARS1
Wikipedia pathwaysTARS1
Orthology - Evolution
OrthoDB6897
GeneTree (enSembl)ENSG00000113407
Phylogenetic Trees/Animal Genes : TreeFamTARS1
Homologs : HomoloGeneTARS1
Homology/Alignments : Family Browser (UCSC)TARS1
Gene fusions - Rearrangements
Fusion : MitelmanZFR/TARS [5p13.3/5p13.3]  
Fusion : QuiverTARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TARS1
dbVarTARS1
ClinVarTARS1
MonarchTARS1
1000_GenomesTARS1 
Exome Variant ServerTARS1
GNOMAD BrowserENSG00000113407
Varsome BrowserTARS1
ACMGTARS1 variants
VarityP26639
Genomic Variants (DGV)TARS1 [DGVbeta]
DECIPHERTARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTARS1 
Mutations
ICGC Data PortalTARS1 
TCGA Data PortalTARS1 
Broad Tumor PortalTARS1
OASIS PortalTARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTARS1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTARS1
DgiDB (Drug Gene Interaction Database)TARS1
DoCM (Curated mutations)TARS1
CIViC (Clinical Interpretations of Variants in Cancer)TARS1
Cancer3DTARS1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187790    618546   
Orphanet
DisGeNETTARS1
MedgenTARS1
Genetic Testing Registry TARS1
NextProtP26639 [Medical]
GENETestsTARS1
Target ValidationTARS1
Huge Navigator TARS1 [HugePedia]
ClinGenTARS1
Clinical trials, drugs, therapy
MyCancerGenomeTARS1
Protein Interactions : CTDTARS1
PharosP26639
Clinical trialTARS1
Miscellaneous
canSAR (ICR)TARS1
HarmonizomeTARS1
DataMed IndexTARS1
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:16 CEST 2021

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