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TARS2 (threonyl-tRNA synthetase 2, mitochondrial (putative))

Identity

Alias_namesTARSL1
threonyl-tRNA synthetase-like 1
Alias_symbol (synonym)FLJ12528
Other aliasCOXPD21
thrRS
HGNC (Hugo) TARS2
LocusID (NCBI) 80222
Atlas_Id 74482
Location 1q21.2  [Link to chromosome band 1q21]
Location_base_pair Starts at 150487364 and ends at 150507609 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EMX1 (2p13.2) / TARS2 (1q21.3)TARS2 (1q21.3) / VPS45 (1q21.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TARS2   30740
Cards
Entrez_Gene (NCBI)TARS2  80222  threonyl-tRNA synthetase 2, mitochondrial (putative)
AliasesCOXPD21; TARSL1; thrRS
GeneCards (Weizmann)TARS2
Ensembl hg19 (Hinxton)ENSG00000143374 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143374 [Gene_View]  chr1:150487364-150507609 [Contig_View]  TARS2 [Vega]
ICGC DataPortalENSG00000143374
TCGA cBioPortalTARS2
AceView (NCBI)TARS2
Genatlas (Paris)TARS2
WikiGenes80222
SOURCE (Princeton)TARS2
Genetics Home Reference (NIH)TARS2
Genomic and cartography
GoldenPath hg38 (UCSC)TARS2  -     chr1:150487364-150507609 +  1q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TARS2  -     1q21.2   [Description]    (hg19-Feb_2009)
EnsemblTARS2 - 1q21.2 [CytoView hg19]  TARS2 - 1q21.2 [CytoView hg38]
Mapping of homologs : NCBITARS2 [Mapview hg19]  TARS2 [Mapview hg38]
OMIM612805   615918   
Gene and transcription
Genbank (Entrez)AK022590 AK222814 AK225368 AK298773 AK315507
RefSeq transcript (Entrez)NM_001271895 NM_001271896 NM_025150
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TARS2
Cluster EST : UnigeneHs.288974 [ NCBI ]
CGAP (NCI)Hs.288974
Alternative Splicing GalleryENSG00000143374
Gene ExpressionTARS2 [ NCBI-GEO ]   TARS2 [ EBI - ARRAY_EXPRESS ]   TARS2 [ SEEK ]   TARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)TARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80222
GTEX Portal (Tissue expression)TARS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BW92   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BW92  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BW92
Splice isoforms : SwissVarQ9BW92
PhosPhoSitePlusQ9BW92
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb    aa-tRNA-synth_II    Anticodon-bd    Beta-grasp_dom    TGS    TGS-like    Thr-tRNA-ligase_IIa    Thr/Ala-tRNA-synth_IIc_edit    ThrRS_core    tRNA_SAD   
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)    TGS (PF02824)    tRNA-synt_2b (PF00587)    tRNA_SAD (PF07973)   
Domain families : Pfam (NCBI)pfam03129    pfam02824    pfam00587    pfam07973   
Domain families : Smart (EMBL)tRNA_SAD (SM00863)  
Conserved Domain (NCBI)TARS2
DMDM Disease mutations80222
Blocks (Seattle)TARS2
SuperfamilyQ9BW92
Human Protein AtlasENSG00000143374
Peptide AtlasQ9BW92
HPRD18148
IPIIPI00604527   IPI00910189   IPI00018632   IPI00640970   IPI00514039   
Protein Interaction databases
DIP (DOE-UCLA)Q9BW92
IntAct (EBI)Q9BW92
FunCoupENSG00000143374
BioGRIDTARS2
STRING (EMBL)TARS2
ZODIACTARS2
Ontologies - Pathways
QuickGOQ9BW92
Ontology : AmiGOaminoacyl-tRNA editing activity  molecular_function  threonine-tRNA ligase activity  threonine-tRNA ligase activity  ATP binding  cellular_component  mitochondrion  mitochondrial matrix  regulation of translational fidelity  protein homodimerization activity  mitochondrial threonyl-tRNA aminoacylation  
Ontology : EGO-EBIaminoacyl-tRNA editing activity  molecular_function  threonine-tRNA ligase activity  threonine-tRNA ligase activity  ATP binding  cellular_component  mitochondrion  mitochondrial matrix  regulation of translational fidelity  protein homodimerization activity  mitochondrial threonyl-tRNA aminoacylation  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkTARS2
Atlas of Cancer Signalling NetworkTARS2
Wikipedia pathwaysTARS2
Orthology - Evolution
OrthoDB80222
GeneTree (enSembl)ENSG00000143374
Phylogenetic Trees/Animal Genes : TreeFamTARS2
HOVERGENQ9BW92
HOGENOMQ9BW92
Homologs : HomoloGeneTARS2
Homology/Alignments : Family Browser (UCSC)TARS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TARS2
dbVarTARS2
ClinVarTARS2
1000_GenomesTARS2 
Exome Variant ServerTARS2
ExAC (Exome Aggregation Consortium)TARS2 (select the gene name)
Genetic variants : HAPMAP80222
Genomic Variants (DGV)TARS2 [DGVbeta]
DECIPHERTARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTARS2 
Mutations
ICGC Data PortalTARS2 
TCGA Data PortalTARS2 
Broad Tumor PortalTARS2
OASIS PortalTARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTARS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TARS2
DgiDB (Drug Gene Interaction Database)TARS2
DoCM (Curated mutations)TARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TARS2 (select a term)
intoGenTARS2
Cancer3DTARS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612805    615918   
Orphanet23122   
MedgenTARS2
Genetic Testing Registry TARS2
NextProtQ9BW92 [Medical]
TSGene80222
GENETestsTARS2
Target ValidationTARS2
Huge Navigator TARS2 [HugePedia]
snp3D : Map Gene to Disease80222
BioCentury BCIQTARS2
ClinGenTARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80222
Chemical/Pharm GKB GenePA162405200
Clinical trialTARS2
Miscellaneous
canSAR (ICR)TARS2 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTARS2
EVEXTARS2
GoPubMedTARS2
iHOPTARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:40:57 CEST 2017

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