TAS2R16 (taste 2 receptor member 16)

2018-07-01  

Identity

HGNC
LOCATION
7q31.32
LOCUSID
ALIAS
BGLPT,T2R16

Other Information

Locus ID:

NCBI: 50833
MIM: 604867
HGNC: 14921
Ensembl: ENSG00000128519

Variants:

dbSNP: 50833
ClinVar: 50833
TCGA: ENSG00000128519
COSMIC: TAS2R16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128519ENST00000249284Q9NYV7

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD
PA448073ethanolChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
123798552002The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.98
163854532006Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.49
172506112007Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.44
172506112007Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.44
185248362008Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans.31
206057882010Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.25
241771852014Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.15
231335892012Bitter taste receptor polymorphisms and human aging.14
217401532011Selection on the human bitter taste gene, TAS2R16, in Eurasian populations.11
209651512010The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides.7

Citation

Dessen P

TAS2R16 (taste 2 receptor member 16)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57422/tas2r16