TAS2R4 (taste 2 receptor member 4)

2021-06-01  

Identity

HGNC
TAS2R4
LOCATION
7q34
LOCUSID
50832
ALIAS
T2R4

Other Information

Locus ID:

NCBI: 50832
MIM: 604869
HGNC: 14911
Ensembl: ENSG00000127364

Variants:

dbSNP: 50832
ClinVar: 50832
TCGA: ENSG00000127364
COSMIC: TAS2R4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127364ENST00000247881Q9NYW5

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
250596682014Amino acid derivatives as bitter taste receptor (T2R) blockers.12
272888922016Cholesterol modulates bitter taste receptor function.7
258447972015Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4.6
231596092013Role of rhodopsin N-terminus in structure and function of rhodopsin-bitter taste receptor chimeras.3
258581112015The structure-function role of C-terminus in human bitter taste receptor T2R4 signaling.2
303019232018Genetic variations in TAS2R3 and TAS2R4 bitterness receptors modify papillary carcinoma risk and thyroid function in Korean females.2
318945292020Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells.2
227941072012Behavioral analysis of Drosophila transformants expressing human taste receptor genes in the gustatory receptor neurons.1
278731432017Regulation of Rac1 GTPase activity by quinine through G-protein and bitter taste receptor T2R4.1

Citation

Dessen P

TAS2R4 (taste 2 receptor member 4)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58179/tas2r4