TASP1 (taspase 1)

2010-08-01  

Identity

HGNC
LOCATION
20p12.1
LOCUSID
ALIAS
C20orf13,SULEHS,dJ585I14.2
FUSION GENES

Other Information

Locus ID:

NCBI: 55617
MIM: 608270
HGNC: 15859
Ensembl: ENSG00000089123

Variants:

dbSNP: 55617
ClinVar: 55617
TCGA: ENSG00000089123
COSMIC: TASP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089123ENST00000337743Q9H6P5
ENSG00000089123ENST00000434275H7BZ38
ENSG00000089123ENST00000455532Q5JWM4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146365572003Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.96
165379152006Uncleaved TFIIA is a substrate for taspase 1 and active in transcription.34
205161192010Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis.15
183950972008EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.14
210843042011Cell-based analysis of structure-function activity of threonine aspartase 1.10
214184512011The importin-alpha/nucleophosmin switch controls taspase1 protease function.8
266571542016Taspase1: a 'misunderstood' protease with translational cancer relevance.7
259965972015Taspase1 processing alters TFIIA cofactor properties in the regulation of TFIID.3
261375842015Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein.1
290977822017Disease-relevant signalling-pathways in head and neck cancer: Taspase1's proteolytic activity fine-tunes TFIIA function.1

Citation

Dessen P

TASP1 (taspase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51633/tasp1