Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TAX1BP1 (Tax1 binding protein 1)

Identity

Alias_namesTax1 (human T-cell leukemia virus type I) binding protein 1
Alias_symbol (synonym)TXBP151
CALCOCO3
Other aliasT6BP
HGNC (Hugo) TAX1BP1
LocusID (NCBI) 8887
Atlas_Id 42473
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 27740095 and ends at 27829767 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK13 (7p14.1) / TAX1BP1 (7p15.2)LDB2 (4p15.32) / TAX1BP1 (7p15.2)SH3GL1 (19p13.3) / TAX1BP1 (7p15.2)
TAX1BP1 (7p15.2) / AHCY (20q11.22)TAX1BP1 (7p15.2) / BRAF (7q34)TAX1BP1 (7p15.2) / JAZF1 (7p15.2)
TAX1BP1 (7p15.2) / MALAT1 (11q13.1)TAX1BP1 (7p15.2) / MRTO4 (1p36.13)TAX1BP1 (7p15.2) / TAX1BP1 (7p15.2)
CDK13 7p14.1 / TAX1BP1 7p15.2SH3GL1 19p13.3 / TAX1BP1 7p15.2TAX1BP1 7p15.2 / JAZF1 7p15.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(7;7)(p14;p15) CDK13/TAX1BP1
TAX1BP1/JAZF1 (7p15)
t(7;7)(p15;q34) TAX1BP1/BRAF
t(7;11)(p15;q13) TAX1BP1/MALAT1
t(7;19)(p15;p13) SH3GL1/TAX1BP1
t(7;20)(p15;q11) TAX1BP1/AHCY


External links

Nomenclature
HGNC (Hugo)TAX1BP1   11575
Cards
Entrez_Gene (NCBI)TAX1BP1  8887  Tax1 binding protein 1
AliasesCALCOCO3; T6BP; TXBP151
GeneCards (Weizmann)TAX1BP1
Ensembl hg19 (Hinxton)ENSG00000106052 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106052 [Gene_View]  ENSG00000106052 [Sequence]  chr7:27740095-27829767 [Contig_View]  TAX1BP1 [Vega]
ICGC DataPortalENSG00000106052
TCGA cBioPortalTAX1BP1
AceView (NCBI)TAX1BP1
Genatlas (Paris)TAX1BP1
WikiGenes8887
SOURCE (Princeton)TAX1BP1
Genetics Home Reference (NIH)TAX1BP1
Genomic and cartography
GoldenPath hg38 (UCSC)TAX1BP1  -     chr7:27740095-27829767 +  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAX1BP1  -     7p15.2   [Description]    (hg19-Feb_2009)
EnsemblTAX1BP1 - 7p15.2 [CytoView hg19]  TAX1BP1 - 7p15.2 [CytoView hg38]
Mapping of homologs : NCBITAX1BP1 [Mapview hg19]  TAX1BP1 [Mapview hg38]
OMIM605326   
Gene and transcription
Genbank (Entrez)AA100874 AA481381 AF090891 AF268075 AI580161
RefSeq transcript (Entrez)NM_001079864 NM_001206901 NM_001206902 NM_001362794 NM_001362795 NM_006024
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAX1BP1
Cluster EST : UnigeneHs.34576 [ NCBI ]
CGAP (NCI)Hs.34576
Alternative Splicing GalleryENSG00000106052
Gene ExpressionTAX1BP1 [ NCBI-GEO ]   TAX1BP1 [ EBI - ARRAY_EXPRESS ]   TAX1BP1 [ SEEK ]   TAX1BP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TAX1BP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8887
GTEX Portal (Tissue expression)TAX1BP1
Human Protein AtlasENSG00000106052-TAX1BP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VP1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VP1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VP1
Splice isoforms : SwissVarQ86VP1
PhosPhoSitePlusQ86VP1
Domains : Interpro (EBI)CALCOCO1-like   
Domain families : Pfam (Sanger)CALCOCO1 (PF07888)   
Domain families : Pfam (NCBI)pfam07888   
Conserved Domain (NCBI)TAX1BP1
DMDM Disease mutations8887
Blocks (Seattle)TAX1BP1
PDB (SRS)2M7Q    4BMJ    4NLH    4Z4K    4Z4M    5AAS   
PDB (PDBSum)2M7Q    4BMJ    4NLH    4Z4K    4Z4M    5AAS   
PDB (IMB)2M7Q    4BMJ    4NLH    4Z4K    4Z4M    5AAS   
PDB (RSDB)2M7Q    4BMJ    4NLH    4Z4K    4Z4M    5AAS   
Structural Biology KnowledgeBase2M7Q    4BMJ    4NLH    4Z4K    4Z4M    5AAS   
SCOP (Structural Classification of Proteins)2M7Q    4BMJ    4NLH    4Z4K    4Z4M    5AAS   
CATH (Classification of proteins structures)2M7Q    4BMJ    4NLH    4Z4K    4Z4M    5AAS   
SuperfamilyQ86VP1
Human Protein Atlas [tissue]ENSG00000106052-TAX1BP1 [tissue]
Peptide AtlasQ86VP1
HPRD05618
IPIIPI00657950   IPI00106559   IPI00908592   IPI00747530   IPI01012775   IPI00916180   IPI00916038   IPI00915925   
Protein Interaction databases
DIP (DOE-UCLA)Q86VP1
IntAct (EBI)Q86VP1
FunCoupENSG00000106052
BioGRIDTAX1BP1
STRING (EMBL)TAX1BP1
ZODIACTAX1BP1
Ontologies - Pathways
QuickGOQ86VP1
Ontology : AmiGOprotein binding  cytosol  apoptotic process  regulation of tumor necrosis factor-mediated signaling pathway  kinase binding  negative regulation of NF-kappaB transcription factor activity  negative regulation of type I interferon production  negative regulation of apoptotic process  metal ion binding  extracellular exosome  
Ontology : EGO-EBIprotein binding  cytosol  apoptotic process  regulation of tumor necrosis factor-mediated signaling pathway  kinase binding  negative regulation of NF-kappaB transcription factor activity  negative regulation of type I interferon production  negative regulation of apoptotic process  metal ion binding  extracellular exosome  
NDEx NetworkTAX1BP1
Atlas of Cancer Signalling NetworkTAX1BP1
Wikipedia pathwaysTAX1BP1
Orthology - Evolution
OrthoDB8887
GeneTree (enSembl)ENSG00000106052
Phylogenetic Trees/Animal Genes : TreeFamTAX1BP1
HOVERGENQ86VP1
HOGENOMQ86VP1
Homologs : HomoloGeneTAX1BP1
Homology/Alignments : Family Browser (UCSC)TAX1BP1
Gene fusions - Rearrangements
Fusion : MitelmanCDK13/TAX1BP1 [7p14.1/7p15.2]  [t(7;7)(p14;p15)]  
Fusion : MitelmanSH3GL1/TAX1BP1 [19p13.3/7p15.2]  [t(7;19)(p15;p13)]  
Fusion : MitelmanTAX1BP1/AHCY [7p15.2/20q11.22]  [t(7;20)(p15;q11)]  
Fusion : MitelmanTAX1BP1/BRAF [7p15.2/7q34]  [t(7;7)(p15;q34)]  
Fusion : MitelmanTAX1BP1/JAZF1 [7p15.2/7p15.2]  [t(7;7)(p15;p15)]  
Fusion : MitelmanTAX1BP1/MALAT1 [7p15.2/11q13.1]  [t(7;11)(p15;q13)]  
Fusion PortalCDK13 7p14.1 TAX1BP1 7p15.2 BRCA
Fusion PortalSH3GL1 19p13.3 TAX1BP1 7p15.2 BRCA
Fusion PortalTAX1BP1 7p15.2 JAZF1 7p15.2 OV
Fusion : QuiverTAX1BP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAX1BP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAX1BP1
dbVarTAX1BP1
ClinVarTAX1BP1
1000_GenomesTAX1BP1 
Exome Variant ServerTAX1BP1
ExAC (Exome Aggregation Consortium)ENSG00000106052
GNOMAD BrowserENSG00000106052
Varsome BrowserTAX1BP1
Genetic variants : HAPMAP8887
Genomic Variants (DGV)TAX1BP1 [DGVbeta]
DECIPHERTAX1BP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAX1BP1 
Mutations
ICGC Data PortalTAX1BP1 
TCGA Data PortalTAX1BP1 
Broad Tumor PortalTAX1BP1
OASIS PortalTAX1BP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAX1BP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAX1BP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAX1BP1
DgiDB (Drug Gene Interaction Database)TAX1BP1
DoCM (Curated mutations)TAX1BP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAX1BP1 (select a term)
intoGenTAX1BP1
Cancer3DTAX1BP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605326   
Orphanet
DisGeNETTAX1BP1
MedgenTAX1BP1
Genetic Testing Registry TAX1BP1
NextProtQ86VP1 [Medical]
TSGene8887
GENETestsTAX1BP1
Target ValidationTAX1BP1
Huge Navigator TAX1BP1 [HugePedia]
snp3D : Map Gene to Disease8887
BioCentury BCIQTAX1BP1
ClinGenTAX1BP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8887
Chemical/Pharm GKB GenePA36339
Clinical trialTAX1BP1
Miscellaneous
canSAR (ICR)TAX1BP1 (select the gene name)
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAX1BP1
EVEXTAX1BP1
GoPubMedTAX1BP1
iHOPTAX1BP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:43:43 CET 2018

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