Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TAX1BP3 (Tax1 binding protein 3)

Identity

Alias_namesTax1 (human T-cell leukemia virus type I) binding protein 3
Alias_symbol (synonym)TIP-1
Other aliasTIP1
HGNC (Hugo) TAX1BP3
LocusID (NCBI) 30851
Atlas_Id 42918
Location 17p13.2  [Link to chromosome band 17p13]
Location_base_pair Starts at 3662893 and ends at 3668679 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SHPK (17p13.2) / TAX1BP3 (17p13.2)TAX1BP3 (17p13.2) / INO80D (2q33.3)TAX1BP3 (17p13.2) / NCBP3 (17p13.2)
TAX1BP3 (17p13.2) / PMP22 (17p12)TAX1BP3 (17p13.2) / UBE2G2 (21q22.3)USF3 (3q13.2) / TAX1BP3 (17p13.2)
TAX1BP3 17p13.2 / C17orf85 17p13.2TAX1BP3 17p13.2 / PMP22 17p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;17)(p12;p13) TAX1BP3/PMP22

External links

Nomenclature
HGNC (Hugo)TAX1BP3   30684
Cards
Entrez_Gene (NCBI)TAX1BP3  30851  Tax1 binding protein 3
AliasesTIP-1; TIP1
GeneCards (Weizmann)TAX1BP3
Ensembl hg19 (Hinxton)ENSG00000213977 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213977 [Gene_View]  ENSG00000213977 [Sequence]  chr17:3662893-3668679 [Contig_View]  TAX1BP3 [Vega]
ICGC DataPortalENSG00000213977
TCGA cBioPortalTAX1BP3
AceView (NCBI)TAX1BP3
Genatlas (Paris)TAX1BP3
WikiGenes30851
SOURCE (Princeton)TAX1BP3
Genetics Home Reference (NIH)TAX1BP3
Genomic and cartography
GoldenPath hg38 (UCSC)TAX1BP3  -     chr17:3662893-3668679 -  17p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAX1BP3  -     17p13.2   [Description]    (hg19-Feb_2009)
GoldenPathTAX1BP3 - 17p13.2 [CytoView hg19]  TAX1BP3 - 17p13.2 [CytoView hg38]
ImmunoBaseENSG00000213977
Mapping of homologs : NCBITAX1BP3 [Mapview hg19]  TAX1BP3 [Mapview hg38]
OMIM616484   
Gene and transcription
Genbank (Entrez)AF028823 AF234997 AF277318 AK001327 AK315408
RefSeq transcript (Entrez)NM_001204698 NM_014604
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAX1BP3
Cluster EST : UnigeneHs.731607 [ NCBI ]
CGAP (NCI)Hs.731607
Alternative Splicing GalleryENSG00000213977
Gene ExpressionTAX1BP3 [ NCBI-GEO ]   TAX1BP3 [ EBI - ARRAY_EXPRESS ]   TAX1BP3 [ SEEK ]   TAX1BP3 [ MEM ]
Gene Expression Viewer (FireBrowse)TAX1BP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)30851
GTEX Portal (Tissue expression)TAX1BP3
Human Protein AtlasENSG00000213977-TAX1BP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14907   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14907  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14907
Splice isoforms : SwissVarO14907
PhosPhoSitePlusO14907
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)   
Domains : Interpro (EBI)PDZ    PDZ_sf    Tax1-binding_p3   
Domain families : Pfam (Sanger)PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)TAX1BP3
DMDM Disease mutations30851
Blocks (Seattle)TAX1BP3
PDB (RSDB)2KG2    2L4S    2L4T    2VZ5    3GJ9    3SFJ    4E3B    4NNL    4NNM   
PDB Europe2KG2    2L4S    2L4T    2VZ5    3GJ9    3SFJ    4E3B    4NNL    4NNM   
PDB (PDBSum)2KG2    2L4S    2L4T    2VZ5    3GJ9    3SFJ    4E3B    4NNL    4NNM   
PDB (IMB)2KG2    2L4S    2L4T    2VZ5    3GJ9    3SFJ    4E3B    4NNL    4NNM   
Structural Biology KnowledgeBase2KG2    2L4S    2L4T    2VZ5    3GJ9    3SFJ    4E3B    4NNL    4NNM   
SCOP (Structural Classification of Proteins)2KG2    2L4S    2L4T    2VZ5    3GJ9    3SFJ    4E3B    4NNL    4NNM   
CATH (Classification of proteins structures)2KG2    2L4S    2L4T    2VZ5    3GJ9    3SFJ    4E3B    4NNL    4NNM   
SuperfamilyO14907
Human Protein Atlas [tissue]ENSG00000213977-TAX1BP3 [tissue]
Peptide AtlasO14907
HPRD18160
IPIIPI00005585   IPI01008856   
Protein Interaction databases
DIP (DOE-UCLA)O14907
IntAct (EBI)O14907
FunCoupENSG00000213977
BioGRIDTAX1BP3
STRING (EMBL)TAX1BP3
ZODIACTAX1BP3
Ontologies - Pathways
QuickGOO14907
Ontology : AmiGOfibrillar center  protein binding  cytoplasm  cytosol  plasma membrane  Rho protein signal transduction  Rho protein signal transduction  beta-catenin binding  protein C-terminus binding  negative regulation of cell proliferation  actin cytoskeleton  Wnt signaling pathway  negative regulation of Wnt signaling pathway  intracellular membrane-bounded organelle  extracellular exosome  activation of GTPase activity  activation of GTPase activity  negative regulation of protein localization to cell surface  negative regulation of protein localization to cell surface  
Ontology : EGO-EBIfibrillar center  protein binding  cytoplasm  cytosol  plasma membrane  Rho protein signal transduction  Rho protein signal transduction  beta-catenin binding  protein C-terminus binding  negative regulation of cell proliferation  actin cytoskeleton  Wnt signaling pathway  negative regulation of Wnt signaling pathway  intracellular membrane-bounded organelle  extracellular exosome  activation of GTPase activity  activation of GTPase activity  negative regulation of protein localization to cell surface  negative regulation of protein localization to cell surface  
NDEx NetworkTAX1BP3
Atlas of Cancer Signalling NetworkTAX1BP3
Wikipedia pathwaysTAX1BP3
Orthology - Evolution
OrthoDB30851
GeneTree (enSembl)ENSG00000213977
Phylogenetic Trees/Animal Genes : TreeFamTAX1BP3
HOGENOMO14907
Homologs : HomoloGeneTAX1BP3
Homology/Alignments : Family Browser (UCSC)TAX1BP3
Gene fusions - Rearrangements
Fusion : MitelmanTAX1BP3/C17orf85 [17p13.2/17p13.2]  
Fusion : MitelmanTAX1BP3/PMP22 [17p13.2/17p12]  [t(17;17)(p12;p13)]  
Fusion PortalTAX1BP3 17p13.2 C17orf85 17p13.2 LUSC
Fusion PortalTAX1BP3 17p13.2 PMP22 17p12 OV
Fusion : QuiverTAX1BP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAX1BP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAX1BP3
dbVarTAX1BP3
ClinVarTAX1BP3
1000_GenomesTAX1BP3 
Exome Variant ServerTAX1BP3
ExAC (Exome Aggregation Consortium)ENSG00000213977
GNOMAD BrowserENSG00000213977
Varsome BrowserTAX1BP3
Genetic variants : HAPMAP30851
Genomic Variants (DGV)TAX1BP3 [DGVbeta]
DECIPHERTAX1BP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAX1BP3 
Mutations
ICGC Data PortalTAX1BP3 
TCGA Data PortalTAX1BP3 
Broad Tumor PortalTAX1BP3
OASIS PortalTAX1BP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAX1BP3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTAX1BP3
Mutations and Diseases : HGMDTAX1BP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAX1BP3
DgiDB (Drug Gene Interaction Database)TAX1BP3
DoCM (Curated mutations)TAX1BP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAX1BP3 (select a term)
intoGenTAX1BP3
Cancer3DTAX1BP3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616484   
Orphanet
DisGeNETTAX1BP3
MedgenTAX1BP3
Genetic Testing Registry TAX1BP3
NextProtO14907 [Medical]
TSGene30851
GENETestsTAX1BP3
Target ValidationTAX1BP3
Huge Navigator TAX1BP3 [HugePedia]
snp3D : Map Gene to Disease30851
BioCentury BCIQTAX1BP3
ClinGenTAX1BP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD30851
Chemical/Pharm GKB GenePA134950693
Clinical trialTAX1BP3
Miscellaneous
canSAR (ICR)TAX1BP3 (select the gene name)
DataMed IndexTAX1BP3
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAX1BP3
EVEXTAX1BP3
GoPubMedTAX1BP3
iHOPTAX1BP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:10:52 CET 2019
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