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TBC1D10B (TBC1 domain family member 10B)

Identity

Alias_namesTBC1 domain family
Alias_symbol (synonym)DKFZP434P1750
Rab27A-GAPbeta
FLJ13130
EPI64B
Other aliasFP2461
HGNC (Hugo) TBC1D10B
LocusID (NCBI) 26000
Atlas_Id 56583
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 30357101 and ends at 30370201 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TBC1D10B (16p11.2) / PPIA (7p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TBC1D10B   24510
Cards
Entrez_Gene (NCBI)TBC1D10B  26000  TBC1 domain family member 10B
AliasesEPI64B; FP2461
GeneCards (Weizmann)TBC1D10B
Ensembl hg19 (Hinxton)ENSG00000169221 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169221 [Gene_View]  chr16:30357101-30370201 [Contig_View]  TBC1D10B [Vega]
ICGC DataPortalENSG00000169221
TCGA cBioPortalTBC1D10B
AceView (NCBI)TBC1D10B
Genatlas (Paris)TBC1D10B
WikiGenes26000
SOURCE (Princeton)TBC1D10B
Genetics Home Reference (NIH)TBC1D10B
Genomic and cartography
GoldenPath hg38 (UCSC)TBC1D10B  -     chr16:30357101-30370201 -  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBC1D10B  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblTBC1D10B - 16p11.2 [CytoView hg19]  TBC1D10B - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBITBC1D10B [Mapview hg19]  TBC1D10B [Mapview hg38]
OMIM613620   
Gene and transcription
Genbank (Entrez)AB449895 AF370370 AI672923 AK002101 AK023192
RefSeq transcript (Entrez)NM_015527
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBC1D10B
Cluster EST : UnigeneHs.632182 [ NCBI ]
CGAP (NCI)Hs.632182
Alternative Splicing GalleryENSG00000169221
Gene ExpressionTBC1D10B [ NCBI-GEO ]   TBC1D10B [ EBI - ARRAY_EXPRESS ]   TBC1D10B [ SEEK ]   TBC1D10B [ MEM ]
Gene Expression Viewer (FireBrowse)TBC1D10B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26000
GTEX Portal (Tissue expression)TBC1D10B
Human Protein AtlasENSG00000169221-TBC1D10B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4KMP7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4KMP7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4KMP7
Splice isoforms : SwissVarQ4KMP7
PhosPhoSitePlusQ4KMP7
Domaine pattern : Prosite (Expaxy)TBC_RABGAP (PS50086)   
Domains : Interpro (EBI)PDEase_catalytic_dom    Rab-GTPase-TBC_dom   
Domain families : Pfam (Sanger)RabGAP-TBC (PF00566)   
Domain families : Pfam (NCBI)pfam00566   
Domain families : Smart (EMBL)TBC (SM00164)  
Conserved Domain (NCBI)TBC1D10B
DMDM Disease mutations26000
Blocks (Seattle)TBC1D10B
SuperfamilyQ4KMP7
Human Protein Atlas [tissue]ENSG00000169221-TBC1D10B [tissue]
Peptide AtlasQ4KMP7
HPRD10892
IPIIPI00465071   IPI00878181   
Protein Interaction databases
DIP (DOE-UCLA)Q4KMP7
IntAct (EBI)Q4KMP7
FunCoupENSG00000169221
BioGRIDTBC1D10B
STRING (EMBL)TBC1D10B
ZODIACTBC1D10B
Ontologies - Pathways
QuickGOQ4KMP7
Ontology : AmiGOGTPase activator activity  protein binding  intracellular  cytosol  plasma membrane  intracellular protein transport  endomembrane system  Rab GTPase binding  regulation of vesicle fusion  retrograde transport, endosome to Golgi  regulation of GTPase activity  activation of GTPase activity  regulation of cilium assembly  
Ontology : EGO-EBIGTPase activator activity  protein binding  intracellular  cytosol  plasma membrane  intracellular protein transport  endomembrane system  Rab GTPase binding  regulation of vesicle fusion  retrograde transport, endosome to Golgi  regulation of GTPase activity  activation of GTPase activity  regulation of cilium assembly  
NDEx NetworkTBC1D10B
Atlas of Cancer Signalling NetworkTBC1D10B
Wikipedia pathwaysTBC1D10B
Orthology - Evolution
OrthoDB26000
GeneTree (enSembl)ENSG00000169221
Phylogenetic Trees/Animal Genes : TreeFamTBC1D10B
HOVERGENQ4KMP7
HOGENOMQ4KMP7
Homologs : HomoloGeneTBC1D10B
Homology/Alignments : Family Browser (UCSC)TBC1D10B
Gene fusions - Rearrangements
Fusion: Tumor Portal TBC1D10B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBC1D10B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBC1D10B
dbVarTBC1D10B
ClinVarTBC1D10B
1000_GenomesTBC1D10B 
Exome Variant ServerTBC1D10B
ExAC (Exome Aggregation Consortium)ENSG00000169221
GNOMAD BrowserENSG00000169221
Genetic variants : HAPMAP26000
Genomic Variants (DGV)TBC1D10B [DGVbeta]
DECIPHERTBC1D10B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBC1D10B 
Mutations
ICGC Data PortalTBC1D10B 
TCGA Data PortalTBC1D10B 
Broad Tumor PortalTBC1D10B
OASIS PortalTBC1D10B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBC1D10B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTBC1D10B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBC1D10B
DgiDB (Drug Gene Interaction Database)TBC1D10B
DoCM (Curated mutations)TBC1D10B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBC1D10B (select a term)
intoGenTBC1D10B
Cancer3DTBC1D10B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613620   
Orphanet
MedgenTBC1D10B
Genetic Testing Registry TBC1D10B
NextProtQ4KMP7 [Medical]
TSGene26000
GENETestsTBC1D10B
Target ValidationTBC1D10B
Huge Navigator TBC1D10B [HugePedia]
snp3D : Map Gene to Disease26000
BioCentury BCIQTBC1D10B
ClinGenTBC1D10B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26000
Chemical/Pharm GKB GenePA142670835
Clinical trialTBC1D10B
Miscellaneous
canSAR (ICR)TBC1D10B (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBC1D10B
EVEXTBC1D10B
GoPubMedTBC1D10B
iHOPTBC1D10B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:13:47 CET 2017

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