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TBC1D15 (TBC1 domain family member 15)

Identity

Alias (NCBI)RAB7-GAP
HGNC (Hugo) TBC1D15
HGNC Alias symbFLJ12085
DKFZp761D0223
HGNC Previous nameTBC1 domain family, member 15
LocusID (NCBI) 64786
Atlas_Id 54689
Location 12q21.1  [Link to chromosome band 12q21]
Location_base_pair Starts at 71839759 and ends at 71927250 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DIP2B (12q13.12) / TBC1D15 (12q21.1)RAB21 (12q21.1) / TBC1D15 (12q21.1)TBC1D15 (12q21.1) / ATF7IP (12p13.1)
TBC1D15 (12q21.1) / BMPER (7p14.3)TBC1D15 (12q21.1) / METTL25 (12q21.31)TBC1D15 (12q21.1) / RP11-419C5.2 ()
TBC1D15 (12q21.1) / TBC1D15 (12q21.1)DIP2B 12q13.12 / TBC1D15 12q21.1TBC1D15 12q21.1 / BMPER 7p14.3
TBC1D15 12q21.1 RP11-419C5.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dup(12)(q21q21) RAB21/TBC1D15


External links

 

Nomenclature
HGNC (Hugo)TBC1D15   25694
Cards
Entrez_Gene (NCBI)TBC1D15    TBC1 domain family member 15
AliasesRAB7-GAP
GeneCards (Weizmann)TBC1D15
Ensembl hg19 (Hinxton)ENSG00000121749 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000121749 [Gene_View]  ENSG00000121749 [Sequence]  chr12:71839759-71927250 [Contig_View]  TBC1D15 [Vega]
ICGC DataPortalENSG00000121749
TCGA cBioPortalTBC1D15
AceView (NCBI)TBC1D15
Genatlas (Paris)TBC1D15
SOURCE (Princeton)TBC1D15
Genetics Home Reference (NIH)TBC1D15
Genomic and cartography
GoldenPath hg38 (UCSC)TBC1D15  -     chr12:71839759-71927250 +  12q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBC1D15  -     12q21.1   [Description]    (hg19-Feb_2009)
GoldenPathTBC1D15 - 12q21.1 [CytoView hg19]  TBC1D15 - 12q21.1 [CytoView hg38]
ImmunoBaseENSG00000121749
Genome Data Viewer NCBITBC1D15 [Mapview hg19]  
OMIM612662   
Gene and transcription
Genbank (Entrez)AB449901 AI590346 AK022147 AK090510 AK225221
RefSeq transcript (Entrez)NM_001146213 NM_001146214 NM_001385848 NM_001385849 NM_001385850 NM_001385851 NM_001385852 NM_001385853 NM_001385854 NM_022771
Consensus coding sequences : CCDS (NCBI)TBC1D15
Gene ExpressionTBC1D15 [ NCBI-GEO ]   TBC1D15 [ EBI - ARRAY_EXPRESS ]   TBC1D15 [ SEEK ]   TBC1D15 [ MEM ]
Gene Expression Viewer (FireBrowse)TBC1D15 [ Firebrowse - Broad ]
GenevisibleExpression of TBC1D15 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64786
GTEX Portal (Tissue expression)TBC1D15
Human Protein AtlasENSG00000121749-TBC1D15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TC07   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TC07  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TC07
PhosPhoSitePlusQ8TC07
Domaine pattern : Prosite (Expaxy)TBC_RABGAP (PS50086)   
Domains : Interpro (EBI)Rab-GTPase-TBC_dom    Rab-GTPase_TBC_sf    SGSM1/2_RBD   
Domain families : Pfam (Sanger)PH_RBD (PF12068)    RabGAP-TBC (PF00566)   
Domain families : Pfam (NCBI)pfam12068    pfam00566   
Domain families : Smart (EMBL)TBC (SM00164)  
Conserved Domain (NCBI)TBC1D15
SuperfamilyQ8TC07
AlphaFold pdb e-kbQ8TC07   
Human Protein Atlas [tissue]ENSG00000121749-TBC1D15 [tissue]
HPRD15470
Protein Interaction databases
DIP (DOE-UCLA)Q8TC07
IntAct (EBI)Q8TC07
BioGRIDTBC1D15
STRING (EMBL)TBC1D15
ZODIACTBC1D15
Ontologies - Pathways
QuickGOQ8TC07
Ontology : AmiGOGTPase activator activity  GTPase activator activity  protein binding  extracellular region  cytoplasm  intracellular protein transport  regulation of GTPase activity  activation of GTPase activity  regulation of cilium assembly  
Ontology : EGO-EBIGTPase activator activity  GTPase activator activity  protein binding  extracellular region  cytoplasm  intracellular protein transport  regulation of GTPase activity  activation of GTPase activity  regulation of cilium assembly  
NDEx NetworkTBC1D15
Atlas of Cancer Signalling NetworkTBC1D15
Wikipedia pathwaysTBC1D15
Orthology - Evolution
OrthoDB64786
GeneTree (enSembl)ENSG00000121749
Phylogenetic Trees/Animal Genes : TreeFamTBC1D15
Homologs : HomoloGeneTBC1D15
Homology/Alignments : Family Browser (UCSC)TBC1D15
Gene fusions - Rearrangements
Fusion : MitelmanDIP2B/TBC1D15 [12q13.12/12q21.1]  
Fusion : MitelmanRAB21/TBC1D15 [12q21.1/12q21.1]  
Fusion : MitelmanTBC1D15/BMPER [12q21.1/7p14.3]  
Fusion : MitelmanTBC1D15/C12orf26 [12q21.1/t(12;12)(q21;q21)]  
Fusion : QuiverTBC1D15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBC1D15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBC1D15
dbVarTBC1D15
ClinVarTBC1D15
MonarchTBC1D15
1000_GenomesTBC1D15 
Exome Variant ServerTBC1D15
GNOMAD BrowserENSG00000121749
Varsome BrowserTBC1D15
ACMGTBC1D15 variants
VarityQ8TC07
Genomic Variants (DGV)TBC1D15 [DGVbeta]
DECIPHERTBC1D15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBC1D15 
Mutations
ICGC Data PortalTBC1D15 
TCGA Data PortalTBC1D15 
Broad Tumor PortalTBC1D15
OASIS PortalTBC1D15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBC1D15  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTBC1D15
Mutations and Diseases : HGMDTBC1D15
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTBC1D15
DgiDB (Drug Gene Interaction Database)TBC1D15
DoCM (Curated mutations)TBC1D15
CIViC (Clinical Interpretations of Variants in Cancer)TBC1D15
Cancer3DTBC1D15
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612662   
Orphanet
DisGeNETTBC1D15
MedgenTBC1D15
Genetic Testing Registry TBC1D15
NextProtQ8TC07 [Medical]
GENETestsTBC1D15
Target ValidationTBC1D15
Huge Navigator TBC1D15 [HugePedia]
ClinGenTBC1D15
Clinical trials, drugs, therapy
MyCancerGenomeTBC1D15
Protein Interactions : CTDTBC1D15
Pharm GKB GenePA134946839
PharosQ8TC07
Clinical trialTBC1D15
Miscellaneous
canSAR (ICR)TBC1D15
HarmonizomeTBC1D15
DataMed IndexTBC1D15
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTBC1D15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:34:20 CEST 2021

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