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TBC1D21 (TBC1 domain family member 21)

Identity

Alias_namescontaining a RabGAP domain
Alias_symbol (synonym)MGC34741
MgcRabGAP
Other alias
HGNC (Hugo) TBC1D21
LocusID (NCBI) 161514
Atlas_Id 55521
Location 15q24.1  [Link to chromosome band 15q24]
Location_base_pair Starts at 74165927 and ends at 74181556 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
OLFM2 (19p13.2) / TBC1D21 (15q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TBC1D21   28536
Cards
Entrez_Gene (NCBI)TBC1D21  161514  TBC1 domain family member 21
AliasesMgcRabGAP
GeneCards (Weizmann)TBC1D21
Ensembl hg19 (Hinxton)ENSG00000167139 [Gene_View]  chr15:74165927-74181556 [Contig_View]  TBC1D21 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167139 [Gene_View]  chr15:74165927-74181556 [Contig_View]  TBC1D21 [Vega]
ICGC DataPortalENSG00000167139
TCGA cBioPortalTBC1D21
AceView (NCBI)TBC1D21
Genatlas (Paris)TBC1D21
WikiGenes161514
SOURCE (Princeton)TBC1D21
Genetics Home Reference (NIH)TBC1D21
Genomic and cartography
GoldenPath hg19 (UCSC)TBC1D21  -     chr15:74165927-74181556 +  15q24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TBC1D21  -     15q24.1   [Description]    (hg38-Dec_2013)
EnsemblTBC1D21 - 15q24.1 [CytoView hg19]  TBC1D21 - 15q24.1 [CytoView hg38]
Mapping of homologs : NCBITBC1D21 [Mapview hg19]  TBC1D21 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB449907 BC033516 HY018107
RefSeq transcript (Entrez)NM_001286434 NM_153356
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)TBC1D21
Cluster EST : UnigeneHs.124512 [ NCBI ]
CGAP (NCI)Hs.124512
Alternative Splicing GalleryENSG00000167139
Gene ExpressionTBC1D21 [ NCBI-GEO ]   TBC1D21 [ EBI - ARRAY_EXPRESS ]   TBC1D21 [ SEEK ]   TBC1D21 [ MEM ]
Gene Expression Viewer (FireBrowse)TBC1D21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)161514
GTEX Portal (Tissue expression)TBC1D21
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYX1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYX1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYX1
Splice isoforms : SwissVarQ8IYX1
PhosPhoSitePlusQ8IYX1
Domaine pattern : Prosite (Expaxy)TBC_RABGAP (PS50086)   
Domains : Interpro (EBI)Rab-GTPase-TBC_dom   
Domain families : Pfam (Sanger)RabGAP-TBC (PF00566)   
Domain families : Pfam (NCBI)pfam00566   
Domain families : Smart (EMBL)TBC (SM00164)  
Conserved Domain (NCBI)TBC1D21
DMDM Disease mutations161514
Blocks (Seattle)TBC1D21
SuperfamilyQ8IYX1
Human Protein AtlasENSG00000167139
Peptide AtlasQ8IYX1
HPRD15473
IPIIPI00217905   IPI00923545   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYX1
IntAct (EBI)Q8IYX1
FunCoupENSG00000167139
BioGRIDTBC1D21
STRING (EMBL)TBC1D21
ZODIACTBC1D21
Ontologies - Pathways
QuickGOQ8IYX1
Ontology : AmiGOacrosomal vesicle  actin binding  GTPase activator activity  intracellular  intracellular protein transport  endomembrane system  Rab GTPase binding  regulation of vesicle fusion  extracellular exosome  activation of GTPase activity  regulation of cilium assembly  
Ontology : EGO-EBIacrosomal vesicle  actin binding  GTPase activator activity  intracellular  intracellular protein transport  endomembrane system  Rab GTPase binding  regulation of vesicle fusion  extracellular exosome  activation of GTPase activity  regulation of cilium assembly  
NDEx NetworkTBC1D21
Atlas of Cancer Signalling NetworkTBC1D21
Wikipedia pathwaysTBC1D21
Orthology - Evolution
OrthoDB161514
GeneTree (enSembl)ENSG00000167139
Phylogenetic Trees/Animal Genes : TreeFamTBC1D21
HOVERGENQ8IYX1
HOGENOMQ8IYX1
Homologs : HomoloGeneTBC1D21
Homology/Alignments : Family Browser (UCSC)TBC1D21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBC1D21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBC1D21
dbVarTBC1D21
ClinVarTBC1D21
1000_GenomesTBC1D21 
Exome Variant ServerTBC1D21
ExAC (Exome Aggregation Consortium)TBC1D21 (select the gene name)
Genetic variants : HAPMAP161514
Genomic Variants (DGV)TBC1D21 [DGVbeta]
DECIPHER (Syndromes)15:74165927-74181556  ENSG00000167139
CONAN: Copy Number AnalysisTBC1D21 
Mutations
ICGC Data PortalTBC1D21 
TCGA Data PortalTBC1D21 
Broad Tumor PortalTBC1D21
OASIS PortalTBC1D21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBC1D21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTBC1D21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBC1D21
DgiDB (Drug Gene Interaction Database)TBC1D21
DoCM (Curated mutations)TBC1D21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBC1D21 (select a term)
intoGenTBC1D21
Cancer3DTBC1D21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTBC1D21
Genetic Testing Registry TBC1D21
NextProtQ8IYX1 [Medical]
TSGene161514
GENETestsTBC1D21
Huge Navigator TBC1D21 [HugePedia]
snp3D : Map Gene to Disease161514
BioCentury BCIQTBC1D21
ClinGenTBC1D21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD161514
Chemical/Pharm GKB GenePA134890585
Clinical trialTBC1D21
Miscellaneous
canSAR (ICR)TBC1D21 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBC1D21
EVEXTBC1D21
GoPubMedTBC1D21
iHOPTBC1D21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:30:24 CET 2017

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