Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TBC1D22B (TBC1 domain family member 22B)

Identity

Alias_namesC6orf197
chromosome 6 open reading frame 197
TBC1 domain family, member 22B
Alias_symbol (synonym)FLJ20337
dJ744I24.2
Other alias
HGNC (Hugo) TBC1D22B
LocusID (NCBI) 55633
Atlas_Id 56530
Location 6p21.2  [Link to chromosome band 6p21]
Location_base_pair Starts at 37257704 and ends at 37332970 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TBC1D22B (6p21.2) / CCND3 (6p21.1)TBC1D22B (6p21.2) / YPEL1 (22q11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  TBC1D22B/CCND3 (6p21)
t(6;22)(p21;q11) TBC1D22B/YPEL1


External links

Nomenclature
HGNC (Hugo)TBC1D22B   21602
Cards
Entrez_Gene (NCBI)TBC1D22B  55633  TBC1 domain family member 22B
AliasesC6orf197
GeneCards (Weizmann)TBC1D22B
Ensembl hg19 (Hinxton)ENSG00000065491 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065491 [Gene_View]  ENSG00000065491 [Sequence]  chr6:37257704-37332970 [Contig_View]  TBC1D22B [Vega]
ICGC DataPortalENSG00000065491
TCGA cBioPortalTBC1D22B
AceView (NCBI)TBC1D22B
Genatlas (Paris)TBC1D22B
WikiGenes55633
SOURCE (Princeton)TBC1D22B
Genetics Home Reference (NIH)TBC1D22B
Genomic and cartography
GoldenPath hg38 (UCSC)TBC1D22B  -     chr6:37257704-37332970 +  6p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBC1D22B  -     6p21.2   [Description]    (hg19-Feb_2009)
EnsemblTBC1D22B - 6p21.2 [CytoView hg19]  TBC1D22B - 6p21.2 [CytoView hg38]
Mapping of homologs : NCBITBC1D22B [Mapview hg19]  TBC1D22B [Mapview hg38]
OMIM616880   
Gene and transcription
Genbank (Entrez)AB449909 AK000344 AK096340 AK292893 AY313781
RefSeq transcript (Entrez)NM_017772
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBC1D22B
Cluster EST : UnigeneHs.731702 [ NCBI ]
CGAP (NCI)Hs.731702
Alternative Splicing GalleryENSG00000065491
Gene ExpressionTBC1D22B [ NCBI-GEO ]   TBC1D22B [ EBI - ARRAY_EXPRESS ]   TBC1D22B [ SEEK ]   TBC1D22B [ MEM ]
Gene Expression Viewer (FireBrowse)TBC1D22B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55633
GTEX Portal (Tissue expression)TBC1D22B
Human Protein AtlasENSG00000065491-TBC1D22B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NU19   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NU19  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NU19
Splice isoforms : SwissVarQ9NU19
PhosPhoSitePlusQ9NU19
Domaine pattern : Prosite (Expaxy)TBC_RABGAP (PS50086)   
Domains : Interpro (EBI)Rab-GTPase-TBC_dom    Rab-GTPase_TBC_sf   
Domain families : Pfam (Sanger)RabGAP-TBC (PF00566)   
Domain families : Pfam (NCBI)pfam00566   
Domain families : Smart (EMBL)TBC (SM00164)  
Conserved Domain (NCBI)TBC1D22B
DMDM Disease mutations55633
Blocks (Seattle)TBC1D22B
PDB (SRS)3DZX   
PDB (PDBSum)3DZX   
PDB (IMB)3DZX   
PDB (RSDB)3DZX   
Structural Biology KnowledgeBase3DZX   
SCOP (Structural Classification of Proteins)3DZX   
CATH (Classification of proteins structures)3DZX   
SuperfamilyQ9NU19
Human Protein Atlas [tissue]ENSG00000065491-TBC1D22B [tissue]
Peptide AtlasQ9NU19
HPRD15475
IPIIPI00002515   IPI00921991   
Protein Interaction databases
DIP (DOE-UCLA)Q9NU19
IntAct (EBI)Q9NU19
FunCoupENSG00000065491
BioGRIDTBC1D22B
STRING (EMBL)TBC1D22B
ZODIACTBC1D22B
Ontologies - Pathways
QuickGOQ9NU19
Ontology : AmiGOGTPase activator activity  protein binding  intracellular  intracellular protein transport  Rab GTPase binding  14-3-3 protein binding  activation of GTPase activity  regulation of cilium assembly  
Ontology : EGO-EBIGTPase activator activity  protein binding  intracellular  intracellular protein transport  Rab GTPase binding  14-3-3 protein binding  activation of GTPase activity  regulation of cilium assembly  
NDEx NetworkTBC1D22B
Atlas of Cancer Signalling NetworkTBC1D22B
Wikipedia pathwaysTBC1D22B
Orthology - Evolution
OrthoDB55633
GeneTree (enSembl)ENSG00000065491
Phylogenetic Trees/Animal Genes : TreeFamTBC1D22B
HOVERGENQ9NU19
HOGENOMQ9NU19
Homologs : HomoloGeneTBC1D22B
Homology/Alignments : Family Browser (UCSC)TBC1D22B
Gene fusions - Rearrangements
Fusion : QuiverTBC1D22B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBC1D22B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBC1D22B
dbVarTBC1D22B
ClinVarTBC1D22B
1000_GenomesTBC1D22B 
Exome Variant ServerTBC1D22B
ExAC (Exome Aggregation Consortium)ENSG00000065491
GNOMAD BrowserENSG00000065491
Varsome BrowserTBC1D22B
Genetic variants : HAPMAP55633
Genomic Variants (DGV)TBC1D22B [DGVbeta]
DECIPHERTBC1D22B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBC1D22B 
Mutations
ICGC Data PortalTBC1D22B 
TCGA Data PortalTBC1D22B 
Broad Tumor PortalTBC1D22B
OASIS PortalTBC1D22B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBC1D22B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTBC1D22B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBC1D22B
DgiDB (Drug Gene Interaction Database)TBC1D22B
DoCM (Curated mutations)TBC1D22B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBC1D22B (select a term)
intoGenTBC1D22B
Cancer3DTBC1D22B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616880   
Orphanet
DisGeNETTBC1D22B
MedgenTBC1D22B
Genetic Testing Registry TBC1D22B
NextProtQ9NU19 [Medical]
TSGene55633
GENETestsTBC1D22B
Target ValidationTBC1D22B
Huge Navigator TBC1D22B [HugePedia]
snp3D : Map Gene to Disease55633
BioCentury BCIQTBC1D22B
ClinGenTBC1D22B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55633
Chemical/Pharm GKB GenePA134867087
Clinical trialTBC1D22B
Miscellaneous
canSAR (ICR)TBC1D22B (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBC1D22B
EVEXTBC1D22B
GoPubMedTBC1D22B
iHOPTBC1D22B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:43:48 CET 2018

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