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TBC1D25 (TBC1 domain family member 25)

Identity

Alias_namesOATL1
ornithine aminotransferase-like 1
TBC1 domain family, member 25
Other aliasMG81
HGNC (Hugo) TBC1D25
LocusID (NCBI) 4943
Atlas_Id 54886
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 48539619 and ends at 48562609 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TBC1D25 (Xp11.23) / ERLIN2 (8p11.23)TBC1D25 (Xp11.23) / HSPA9 (5q31.2)TBC1D25 Xp11.23 / ERLIN2 8p11.23
TBC1D25 Xp11.23 / HSPA9 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TBC1D25   8092
Cards
Entrez_Gene (NCBI)TBC1D25  4943  TBC1 domain family member 25
AliasesMG81; OATL1
GeneCards (Weizmann)TBC1D25
Ensembl hg19 (Hinxton)ENSG00000068354 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000068354 [Gene_View]  chrX:48539619-48562609 [Contig_View]  TBC1D25 [Vega]
ICGC DataPortalENSG00000068354
TCGA cBioPortalTBC1D25
AceView (NCBI)TBC1D25
Genatlas (Paris)TBC1D25
WikiGenes4943
SOURCE (Princeton)TBC1D25
Genetics Home Reference (NIH)TBC1D25
Genomic and cartography
GoldenPath hg38 (UCSC)TBC1D25  -     chrX:48539619-48562609 +  Xp11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBC1D25  -     Xp11.23   [Description]    (hg19-Feb_2009)
EnsemblTBC1D25 - Xp11.23 [CytoView hg19]  TBC1D25 - Xp11.23 [CytoView hg38]
Mapping of homologs : NCBITBC1D25 [Mapview hg19]  TBC1D25 [Mapview hg38]
OMIM311240   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001006113 NM_001348262 NM_001348263 NM_001348264 NM_001348265 NM_002536
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBC1D25
Cluster EST : UnigeneHs.694353 [ NCBI ]
CGAP (NCI)Hs.694353
Alternative Splicing GalleryENSG00000068354
Gene ExpressionTBC1D25 [ NCBI-GEO ]   TBC1D25 [ EBI - ARRAY_EXPRESS ]   TBC1D25 [ SEEK ]   TBC1D25 [ MEM ]
Gene Expression Viewer (FireBrowse)TBC1D25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4943
GTEX Portal (Tissue expression)TBC1D25
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ3MII6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ3MII6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ3MII6
Splice isoforms : SwissVarQ3MII6
PhosPhoSitePlusQ3MII6
Domaine pattern : Prosite (Expaxy)TBC_RABGAP (PS50086)   
Domains : Interpro (EBI)Rab-GTPase-TBC_dom   
Domain families : Pfam (Sanger)RabGAP-TBC (PF00566)   
Domain families : Pfam (NCBI)pfam00566   
Domain families : Smart (EMBL)TBC (SM00164)  
Conserved Domain (NCBI)TBC1D25
DMDM Disease mutations4943
Blocks (Seattle)TBC1D25
SuperfamilyQ3MII6
Human Protein AtlasENSG00000068354
Peptide AtlasQ3MII6
HPRD08948
IPIIPI00844277   IPI01015110   IPI00296736   IPI00645704   
Protein Interaction databases
DIP (DOE-UCLA)Q3MII6
IntAct (EBI)Q3MII6
FunCoupENSG00000068354
BioGRIDTBC1D25
STRING (EMBL)TBC1D25
ZODIACTBC1D25
Ontologies - Pathways
QuickGOQ3MII6
Ontology : AmiGOGTPase activator activity  protein binding  autophagosome  autophagosome  intracellular protein transport  autophagy  endomembrane system  Rab GTPase binding  regulation of vesicle fusion  cytoplasmic vesicle  membrane organization  activation of GTPase activity  regulation of autophagosome maturation  
Ontology : EGO-EBIGTPase activator activity  protein binding  autophagosome  autophagosome  intracellular protein transport  autophagy  endomembrane system  Rab GTPase binding  regulation of vesicle fusion  cytoplasmic vesicle  membrane organization  activation of GTPase activity  regulation of autophagosome maturation  
NDEx NetworkTBC1D25
Atlas of Cancer Signalling NetworkTBC1D25
Wikipedia pathwaysTBC1D25
Orthology - Evolution
OrthoDB4943
GeneTree (enSembl)ENSG00000068354
Phylogenetic Trees/Animal Genes : TreeFamTBC1D25
HOVERGENQ3MII6
HOGENOMQ3MII6
Homologs : HomoloGeneTBC1D25
Homology/Alignments : Family Browser (UCSC)TBC1D25
Gene fusions - Rearrangements
Fusion : MitelmanTBC1D25/ERLIN2 [Xp11.23/8p11.23]  
Fusion : MitelmanTBC1D25/HSPA9 [Xp11.23/5q31.2]  [t(X;5)(p11;q31)]  
Fusion: TCGATBC1D25 Xp11.23 ERLIN2 8p11.23 BRCA
Fusion: TCGATBC1D25 Xp11.23 HSPA9 5q31.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBC1D25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBC1D25
dbVarTBC1D25
ClinVarTBC1D25
1000_GenomesTBC1D25 
Exome Variant ServerTBC1D25
ExAC (Exome Aggregation Consortium)TBC1D25 (select the gene name)
Genetic variants : HAPMAP4943
Genomic Variants (DGV)TBC1D25 [DGVbeta]
DECIPHERTBC1D25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBC1D25 
Mutations
ICGC Data PortalTBC1D25 
TCGA Data PortalTBC1D25 
Broad Tumor PortalTBC1D25
OASIS PortalTBC1D25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBC1D25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTBC1D25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBC1D25
DgiDB (Drug Gene Interaction Database)TBC1D25
DoCM (Curated mutations)TBC1D25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBC1D25 (select a term)
intoGenTBC1D25
Cancer3DTBC1D25(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM311240   
Orphanet
MedgenTBC1D25
Genetic Testing Registry TBC1D25
NextProtQ3MII6 [Medical]
TSGene4943
GENETestsTBC1D25
Target ValidationTBC1D25
Huge Navigator TBC1D25 [HugePedia]
snp3D : Map Gene to Disease4943
BioCentury BCIQTBC1D25
ClinGenTBC1D25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4943
Chemical/Pharm GKB GenePA162405201
Clinical trialTBC1D25
Miscellaneous
canSAR (ICR)TBC1D25 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBC1D25
EVEXTBC1D25
GoPubMedTBC1D25
iHOPTBC1D25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:58:40 CEST 2017

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