Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TBCK (TBC1 domain containing kinase)

Identity

Alias (NCBI)HSPC302
IHPRF3
TBCKL
HGNC (Hugo) TBCK
HGNC Alias symbMGC16169
HSPC302
LocusID (NCBI) 93627
Atlas_Id 41350
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 106041599 and ends at 106316209 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TBCK (4q24) / USP10 (16q24.1)TBCK 4q24 / USP10 16q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TBCK   28261
LRG (Locus Reference Genomic)LRG_836
Cards
Entrez_Gene (NCBI)TBCK    TBC1 domain containing kinase
AliasesHSPC302; IHPRF3; TBCKL
GeneCards (Weizmann)TBCK
Ensembl hg19 (Hinxton)ENSG00000145348 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145348 [Gene_View]  ENSG00000145348 [Sequence]  chr4:106041599-106316209 [Contig_View]  TBCK [Vega]
ICGC DataPortalENSG00000145348
TCGA cBioPortalTBCK
AceView (NCBI)TBCK
Genatlas (Paris)TBCK
SOURCE (Princeton)TBCK
Genetics Home Reference (NIH)TBCK
Genomic and cartography
GoldenPath hg38 (UCSC)TBCK  -     chr4:106041599-106316209 -  4q24   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBCK  -     4q24   [Description]    (hg19-Feb_2009)
GoldenPathTBCK - 4q24 [CytoView hg19]  TBCK - 4q24 [CytoView hg38]
ImmunoBaseENSG00000145348
Genome Data Viewer NCBITBCK [Mapview hg19]  
OMIM616899   616900   
Gene and transcription
Genbank (Entrez)AB449876 AF161420 AI279137 AI808636 AK074305
RefSeq transcript (Entrez)NM_001163435 NM_001163436 NM_001163437 NM_001290768 NM_033115
Consensus coding sequences : CCDS (NCBI)TBCK
Gene ExpressionTBCK [ NCBI-GEO ]   TBCK [ EBI - ARRAY_EXPRESS ]   TBCK [ SEEK ]   TBCK [ MEM ]
Gene Expression Viewer (FireBrowse)TBCK [ Firebrowse - Broad ]
GenevisibleExpression of TBCK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)93627
GTEX Portal (Tissue expression)TBCK
Human Protein AtlasENSG00000145348-TBCK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEA7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEA7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEA7
PhosPhoSitePlusQ8TEA7
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    RHODANESE_3 (PS50206)    TBC_RABGAP (PS50086)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Rab-GTPase-TBC_dom    Rab-GTPase_TBC_sf    Rhodanese-like_dom    Rhodanese-like_dom_sf   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RabGAP-TBC (PF00566)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00069    pfam00566    pfam00581   
Domain families : Smart (EMBL)RHOD (SM00450)  TBC (SM00164)  
Conserved Domain (NCBI)TBCK
SuperfamilyQ8TEA7
AlphaFold pdb e-kbQ8TEA7   
Human Protein Atlas [tissue]ENSG00000145348-TBCK [tissue]
HPRD17514
Protein Interaction databases
DIP (DOE-UCLA)Q8TEA7
IntAct (EBI)Q8TEA7
BioGRIDTBCK
STRING (EMBL)TBCK
ZODIACTBCK
Ontologies - Pathways
QuickGOQ8TEA7
Ontology : AmiGOprotein kinase activity  GTPase activator activity  ATP binding  cytoplasm  protein phosphorylation  intracellular protein transport  cell population proliferation  actin cytoskeleton organization  midbody  regulation of TOR signaling  mitotic spindle  activation of GTPase activity  
Ontology : EGO-EBIprotein kinase activity  GTPase activator activity  ATP binding  cytoplasm  protein phosphorylation  intracellular protein transport  cell population proliferation  actin cytoskeleton organization  midbody  regulation of TOR signaling  mitotic spindle  activation of GTPase activity  
NDEx NetworkTBCK
Atlas of Cancer Signalling NetworkTBCK
Wikipedia pathwaysTBCK
Orthology - Evolution
OrthoDB93627
GeneTree (enSembl)ENSG00000145348
Phylogenetic Trees/Animal Genes : TreeFamTBCK
Homologs : HomoloGeneTBCK
Homology/Alignments : Family Browser (UCSC)TBCK
Gene fusions - Rearrangements
Fusion : MitelmanTBCK/USP10 [4q24/16q24.1]  
Fusion : QuiverTBCK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBCK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBCK
dbVarTBCK
ClinVarTBCK
MonarchTBCK
1000_GenomesTBCK 
Exome Variant ServerTBCK
GNOMAD BrowserENSG00000145348
Varsome BrowserTBCK
ACMGTBCK variants
VarityQ8TEA7
Genomic Variants (DGV)TBCK [DGVbeta]
DECIPHERTBCK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBCK 
Mutations
ICGC Data PortalTBCK 
TCGA Data PortalTBCK 
Broad Tumor PortalTBCK
OASIS PortalTBCK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBCK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTBCK
Mutations and Diseases : HGMDTBCK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTBCK
DgiDB (Drug Gene Interaction Database)TBCK
DoCM (Curated mutations)TBCK
CIViC (Clinical Interpretations of Variants in Cancer)TBCK
Cancer3DTBCK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616899    616900   
Orphanet
DisGeNETTBCK
MedgenTBCK
Genetic Testing Registry TBCK
NextProtQ8TEA7 [Medical]
GENETestsTBCK
Target ValidationTBCK
Huge Navigator TBCK [HugePedia]
ClinGenTBCK
Clinical trials, drugs, therapy
MyCancerGenomeTBCK
Protein Interactions : CTDTBCK
Pharm GKB GenePA165664603
PharosQ8TEA7
Clinical trialTBCK
Miscellaneous
canSAR (ICR)TBCK
HarmonizomeTBCK
DataMed IndexTBCK
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTBCK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:28 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.