Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TBCK (TBC1 domain containing kinase)

Identity

Alias_symbol (synonym)MGC16169
HSPC302
Other aliasIHPRF3
TBCKL
HGNC (Hugo) TBCK
LocusID (NCBI) 93627
Atlas_Id 41350
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 106044317 and ends at 106316266 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TBCK (4q24) / USP10 (16q24.1)TBCK 4q24 / USP10 16q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TBCK   28261
LRG (Locus Reference Genomic)LRG_836
Cards
Entrez_Gene (NCBI)TBCK  93627  TBC1 domain containing kinase
AliasesHSPC302; IHPRF3; TBCKL
GeneCards (Weizmann)TBCK
Ensembl hg19 (Hinxton)ENSG00000145348 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145348 [Gene_View]  chr4:106044317-106316266 [Contig_View]  TBCK [Vega]
ICGC DataPortalENSG00000145348
TCGA cBioPortalTBCK
AceView (NCBI)TBCK
Genatlas (Paris)TBCK
WikiGenes93627
SOURCE (Princeton)TBCK
Genetics Home Reference (NIH)TBCK
Genomic and cartography
GoldenPath hg38 (UCSC)TBCK  -     chr4:106044317-106316266 -  4q24   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBCK  -     4q24   [Description]    (hg19-Feb_2009)
EnsemblTBCK - 4q24 [CytoView hg19]  TBCK - 4q24 [CytoView hg38]
Mapping of homologs : NCBITBCK [Mapview hg19]  TBCK [Mapview hg38]
OMIM616899   616900   
Gene and transcription
Genbank (Entrez)AB449876 AF161420 AI279137 AI808636 AK074305
RefSeq transcript (Entrez)NM_001163435 NM_001163436 NM_001163437 NM_001290768 NM_033115
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBCK
Cluster EST : UnigeneHs.292986 [ NCBI ]
CGAP (NCI)Hs.292986
Alternative Splicing GalleryENSG00000145348
Gene ExpressionTBCK [ NCBI-GEO ]   TBCK [ EBI - ARRAY_EXPRESS ]   TBCK [ SEEK ]   TBCK [ MEM ]
Gene Expression Viewer (FireBrowse)TBCK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)93627
GTEX Portal (Tissue expression)TBCK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEA7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEA7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEA7
Splice isoforms : SwissVarQ8TEA7
PhosPhoSitePlusQ8TEA7
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    RHODANESE_3 (PS50206)    TBC_RABGAP (PS50086)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Rab-GTPase-TBC_dom    Rhodanese-like_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RabGAP-TBC (PF00566)    Rhodanese (PF00581)   
Domain families : Pfam (NCBI)pfam00069    pfam00566    pfam00581   
Domain families : Smart (EMBL)RHOD (SM00450)  TBC (SM00164)  
Conserved Domain (NCBI)TBCK
DMDM Disease mutations93627
Blocks (Seattle)TBCK
SuperfamilyQ8TEA7
Human Protein AtlasENSG00000145348
Peptide AtlasQ8TEA7
HPRD17514
IPIIPI00291665   IPI00791217   IPI00062810   IPI00967488   IPI00964298   IPI00964813   IPI00965264   IPI00964472   IPI00967666   IPI00964009   IPI00968186   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEA7
IntAct (EBI)Q8TEA7
FunCoupENSG00000145348
BioGRIDTBCK
STRING (EMBL)TBCK
ZODIACTBCK
Ontologies - Pathways
QuickGOQ8TEA7
Ontology : AmiGOprotein kinase activity  GTPase activator activity  ATP binding  intracellular  cytoplasm  protein phosphorylation  intracellular protein transport  cell proliferation  endomembrane system  cell growth  Rab GTPase binding  actin cytoskeleton organization  midbody  regulation of vesicle fusion  regulation of TOR signaling  mitotic spindle  activation of GTPase activity  
Ontology : EGO-EBIprotein kinase activity  GTPase activator activity  ATP binding  intracellular  cytoplasm  protein phosphorylation  intracellular protein transport  cell proliferation  endomembrane system  cell growth  Rab GTPase binding  actin cytoskeleton organization  midbody  regulation of vesicle fusion  regulation of TOR signaling  mitotic spindle  activation of GTPase activity  
NDEx NetworkTBCK
Atlas of Cancer Signalling NetworkTBCK
Wikipedia pathwaysTBCK
Orthology - Evolution
OrthoDB93627
GeneTree (enSembl)ENSG00000145348
Phylogenetic Trees/Animal Genes : TreeFamTBCK
HOVERGENQ8TEA7
HOGENOMQ8TEA7
Homologs : HomoloGeneTBCK
Homology/Alignments : Family Browser (UCSC)TBCK
Gene fusions - Rearrangements
Fusion : MitelmanTBCK/USP10 [4q24/16q24.1]  
Fusion: TCGATBCK 4q24 USP10 16q24.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBCK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBCK
dbVarTBCK
ClinVarTBCK
1000_GenomesTBCK 
Exome Variant ServerTBCK
ExAC (Exome Aggregation Consortium)TBCK (select the gene name)
Genetic variants : HAPMAP93627
Genomic Variants (DGV)TBCK [DGVbeta]
DECIPHERTBCK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBCK 
Mutations
ICGC Data PortalTBCK 
TCGA Data PortalTBCK 
Broad Tumor PortalTBCK
OASIS PortalTBCK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBCK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTBCK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBCK
DgiDB (Drug Gene Interaction Database)TBCK
DoCM (Curated mutations)TBCK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBCK (select a term)
intoGenTBCK
Cancer3DTBCK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616899    616900   
Orphanet
MedgenTBCK
Genetic Testing Registry TBCK
NextProtQ8TEA7 [Medical]
TSGene93627
GENETestsTBCK
Huge Navigator TBCK [HugePedia]
snp3D : Map Gene to Disease93627
BioCentury BCIQTBCK
ClinGenTBCK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD93627
Chemical/Pharm GKB GenePA165664603
Clinical trialTBCK
Miscellaneous
canSAR (ICR)TBCK (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBCK
EVEXTBCK
GoPubMedTBCK
iHOPTBCK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:40:25 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.